ID2

Official Full Name

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Overview

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional;regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA;binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by;suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively;regulating cell differentiation. A pseudogene of this gene is located on chromosome 3.
Synonyms

ID2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; DNA-binding protein inhibitor ID-2; bHLHb26; cell growth inhibiting gene 8; GIG8; helix-loop-helix protein ID2; cell growth-inhibiting gene 8; inhibitor of differentiation 2; DNA;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

His
Fc
Avi
SUMO
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ID2-7547H	Recombinant Human ID2, His-tagged	E.coli	His	1-134aa	Inquiry
Human	ID2-28380TH	Recombinant Human ID2	Wheat Germ	Non	135 amino acids	Inquiry
Human	ID2-5311HCL	Recombinant Human ID2 293 Cell Lysate	HEK293	Non		Inquiry
Human	ID2-245HF	Active Recombinant Full Length Human ID2 Protein	In Vitro Cell Free System		135 amino acids	Inquiry
Human	ID2-3063H	Recombinant Human ID2 protein, His-SUMO-tagged	E.coli	His&SUMO	1-134aa	Inquiry
Mouse	ID2-7980M	Recombinant Mouse ID2 Protein	Mammalian Cell	His		Inquiry
Mouse	Id2-1208M	Recombinant Mouse Id2 Protein, MYC/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	ID2-4406M-B	Recombinant Mouse ID2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	ID2-4406M	Recombinant Mouse ID2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	ID2-2982R	Recombinant Rat ID2 Protein	Mammalian Cell	His		Inquiry
Rat	ID2-2637R	Recombinant Rat ID2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	ID2-2637R-B	Recombinant Rat ID2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	ID2-6560C	Recombinant Chicken ID2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ID2 involved in several pathways and played different roles in them. We selected most pathways ID2 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ID2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
TGF-beta signaling pathway	SMAD9;ZFYVE16;CUL1A;SP1;LEFTY1;BMP2;NOG3;ACVR1L;SMAD7
Hippo signaling pathway	WNT8B;RASSF1;ID1;TEAD2;AXIN1;SERPINE1;APC2;WWC1;FZD10
Signaling pathways regulating pluripotency of stem cells	STAT3;FZD8;MAPK3;BMPR1A;PCGF6;FZD7;WNT1;WNT3;WNT8B
Transcriptional misregulation in cancer	SS18;WNT16;BMP2K;ITGAM;MLF1;TRAF1;Pdgfa&Pdgfb;HOXA9;SP1

ID2 has several biochemical functions, for example, ion channel binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ID2 itself. We selected most functions ID2 had, and list some proteins which have the same functions with ID2. You can find most of the proteins on our site.

Function	Related Protein
ion channel binding	ANK2;VDAC1;RYR2;SLC8A1;CHERP;FGF13;YWHAQ;CIB1;KCNJ11
protein binding	KRTAP12-1;SF1;BIRC7;CFLAR;PRDX3;COL1A1;CYGB;NRG4;TIMM9
protein dimerization activity	POLR2J2;MYO5A;NEUROG3;SOHLH1;HER12;OLIG4;TCF23;USF1L;NUP210

ID2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ID2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ID2.

PKD2; TCF3; CCNDBP1; SUV39H1; KDM1A; HSPA5; MAPK3; MAPK1; MAPK8

Research Area

Neural Progenitor Cell Markers

Neural Stem Cell Markers

Natural Killer T (NKT) Cells

Dendritic Cell Development

Cancer Stem Cell Transcription Factors

Gnidehou, S; Doritchamou, J; et al. Functional Antibodies against VAR2CSA in Nonpregnant Populations from Colombia Exposed to Plasmodium falciparum and Plasmodium vivax. INFECTION AND IMMUNITY 82:2565-2573(2014).

Kusama, H; Kobayashi, R; et al. Midazolam inhibits IgE production in mice via suppression of class switch recombination. JOURNAL OF ORAL SCIENCE 56:77-83(2014).