IL12RB1 Protein


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Official Full Name interleukin 12 receptor, beta 1
Background The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor;superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12;receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The;coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and;reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the;immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript;variants of this gene encoding distinct isoforms have been reported.
Synonyms IL12RB1; interleukin 12 receptor, beta 1; IL12RB; interleukin-12 receptor subunit beta-1; CD212; I12R1_HUMAN; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL12 receptor beta component; Interleukin 12 receptor beta 1 chain; Interleukin 12 receptor subunit beta 1; MGC34454; interleukin-12 receptor beta-1 chain; IL-12R-BETA1
    • Species :
    • Cynomolgus
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Source :
    • CHO cells
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc/Avi
    • His
    • GST
    • human
    • IgG1
    • Fc
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL12RB1-051H Recombinant Human IL12RB1 protein, Fc-Avi-tagged, Biotinylated CHO cells Fc/Avi
    Human IL12RB1-1649H Recombinant Human Interleukin 12 Receptor, Beta 1 Mammalian cells N/A
    Human IL12RB1-1733H Recombinant Human IL12RB1 protein, His-tagged E.coli His
    Human IL12RB1-3230H Recombinant Human IL12RB1 protein, His-tagged HEK293 His
    Human IL12RB1-62H Recombinant Human IL12RB1, His-tagged Insect Cell His
    Human IL12RB1-8326H Recombinant Human IL12RB1 Mammalian cells N/A
    Mouse Il12rb1-1734M Recombinant Mouse Il12rb1 protein, His & GST-tagged E.coli His/GST
    Mouse IL12RB1-8114M Recombinant Mouse IL12RB1 Protein Mammalian Cell His
    Mouse Il12rb1-8337M Recombinant Mouse Il12rb1 Mammalian cells N/A
    Human IL12RB1-2188HCL Recombinant Human IL12RB1 cell lysate Human Cell N/A
    Cynomolgus IL12RB1-671C Recombinant Cynomolgus IL12RB1 protein, His-tagged HEK293 His
    Homo sapiens (Human) RFL3414HF Recombinant Full Length Human Interleukin-12 Receptor Subunit Beta-1(Il12Rb1) Protein, His-Tagged E.coli expression system His
    Human IL12RB1-73H Recombinant Human IL12RB1 protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Il12rb1-1238M Recombinant Mouse Il12rb1 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    IL12RB1 involved in several pathways and played different roles in them. We selected most pathways IL12RB1 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12RB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL4L2; IL8L1; CXCL5; IL2RB; GHRA; TNFRSF10C; TNFRSF11A; GM2002; CCL20B; CTF1
    Jak-STAT signaling pathway IFNA7; AOX1; MCL1; FHL1A; MCL1A; Il4ra; IFNA13; IL4R; IL10RA; CISHB
    Inflammatory bowel disease (IBD) NFKB1; HLA-DPA1; IFNGR1; TGFB1; SMAD3; IL18RAP; IL23R; STAT4; IL4R; IL2RG

    IL12RB1 has several biochemical functions, for example, cytokine receptor activity, contributes_to interleukin-12 receptor activity, contributes_to interleukin-12 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12RB1 itself. We selected most functions IL12RB1 had, and list some proteins which have the same functions with IL12RB1. You can find most of the proteins on our site.

    Function Related Protein
    cytokine receptor activity FLT3; IRX1; CD74; LEPR; IL12RB2; Il6ra; CRFB17; LIFRB; IL11RA; F3B
    contributes_to interleukin-12 receptor activity IL12RB1
    contributes_to interleukin-12 receptor binding IL12B; IL12RB1; IL23R
    contributes_to interleukin-23 binding IL12RB1; IL23R
    contributes_to interleukin-23 receptor activity IL12RB1; IL23R

    IL12RB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12RB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12RB1.

    IL12A; IL12B; SNRPD3; il23a_il-12b_human

    Famulski, KS; Reeve, J; et al. Kidney Transplants With Progressing Chronic Diseases Express High Levels of Acute Kidney Injury Transcripts. AMERICAN JOURNAL OF TRANSPLANTATION 13:634-644(2013).
    Tang, SW; Yang, TC; et al. Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells. CARCINOGENESIS 32:138-145(2011).


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