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IL12RB1

  • Official Full Name

    interleukin 12 receptor, beta 1

  • Overview

    The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor;superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12;receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The;coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and;reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the;immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript;variants of this gene encoding distinct isoforms have been reported.
  • Synonyms

    IL12RB1; interleukin 12 receptor, beta 1; IL12RB; interleukin-12 receptor subunit beta-1; CD212; I12R1_HUMAN; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; IL12 receptor beta component; Interleukin 12 receptor beta 1 chain; Interleukin 12 receptor subunit beta 1; MGC34454; interleukin-12 receptor beta-1 chain; IL-12R-BETA1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Homo sapiens (Human)
  • Human
  • Mouse
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • Avi
  • His (Fc)
  • His|GST
  • human|IgG1|Fc
  • MYC
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL12RB1-051H Active Recombinant Human IL12RB1 protein, Fc-Avi-tagged, Biotinylated CHO cells Fc/Avi Cys24-Glu540
Human IL12RB1-1733H Recombinant Human IL12RB1 protein, His-tagged E.coli His Pro37~Glu234 (Accession # P42701)
Human IL12RB1-8326H Recombinant Human IL12RB1 Mammalian cells N/A
Human IL12RB1-62H Recombinant Human IL12RB1, His-tagged Insect Cell His
Human IL12RB1-3230H Active Recombinant Human IL12RB1 protein, His-tagged HEK293 His Met1-Glu540
Human IL12RB1-1649H Recombinant Human Interleukin 12 Receptor, Beta 1 Mammalian cells N/A
Human IL12RB1-2188HCL Recombinant Human IL12RB1 cell lysate Human Cell N/A
Human IL12RB1-4432H Recombinant Human IL12RB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL12RB1-73H Recombinant Human IL12RB1 protein, Fc-tagged HEK293 human/IgG1/Fc Cys24-Glu540
Human IL12RB1-0228H Active Recombinant Human IL12RB1 protein, Fc-tagged HEK293 Fc Cys24-Glu540
Human IL12RB1-074H Recombinant Human IL12RB1 Protein, His-tagged E.coli His
Human IL12RB1-0226H Active Recombinant Human IL12RB1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Cys24-Glu540
Human IL12RB1-4432H-B Recombinant Human IL12RB1 Protein Pre-coupled Magnetic Beads HEK293
Human IL12RB1-0229H Active Recombinant Human IL12RB1 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Cys24-Glu540
Human IL12RB1-3372H Recombinant Human IL12RB1 Protein (Pro37-Glu234), His tagged E.coli His Pro37-Glu234
Human IL12RB1-4306H Recombinant Human IL12RB1 Protein (Met1-Glu540), C-His tagged Mammalian cells C-His Met1-Glu540
Mouse Il12rb1-1734M Recombinant Mouse Il12rb1 protein, His & GST-tagged E.coli His/GST Gln197~Arg348 (Accession # Q60837)
Mouse Il12rb1-8337M Recombinant Mouse Il12rb1 Mammalian cells N/A
Mouse IL12RB1-8114M Recombinant Mouse IL12RB1 Protein Mammalian Cell His
Mouse IL12RB1-0225M Active Recombinant Mouse IL12RB1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln20-Ser565
Mouse Il12rb1-1238M Recombinant Mouse Il12rb1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Il12rb1-10576M Recombinant Mouse Il12rb1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il12rb1-10576M-B Recombinant Mouse Il12rb1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus IL12RB1-0227C Active Recombinant Cynomolgus IL12RB1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Cys24-Asp545
Cynomolgus IL12RB1-671C Recombinant Cynomolgus IL12RB1 protein, His-tagged HEK293 His Met1-Asp545
Homo sapiens (Human) RFL3414HF Recombinant Full Length Human Interleukin-12 Receptor Subunit Beta-1(Il12Rb1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-662)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL12RB1 Related Articles
  • IL12RB1 Related Gene Family
  • IL12RB1 Related Research Area
  • IL12RB1 Related Signal Pathway

IL12RB1 involved in several pathways and played different roles in them. We selected most pathways IL12RB1 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with IL12RB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL6;GHR;Ccl27a;OSM;VEGFC;CCL11;XCL2;ACVR1BA;TNFSF18
Jak-STAT signaling pathwayMYCB;STAM2;LEP;PIK3CA;GH1;IL23R;IFNGR2;IFNA12;IL17D
Inflammatory bowel disease (IBD)TGFB2;IL22;MAF;IL4R;IL6;IL21R;RELA;IL18R1;HLA-DMB

IL12RB1 has several biochemical functions, for example, cytokine receptor activity, contributes_to interleukin-12 receptor activity, contributes_to interleukin-12 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL12RB1 itself. We selected most functions IL12RB1 had, and list some proteins which have the same functions with IL12RB1. You can find most of the proteins on our site.

Function Related Protein
cytokine receptor activityIL11RA;Il4ra;CRFB15;CRFB17;GHR;CRFB4;LEPR;IL28RA;IL31RA
contributes_to interleukin-12 receptor activity
contributes_to interleukin-12 receptor bindingIL23R;IL12RB1;IL12B
contributes_to interleukin-23 bindingIL23R;IL12RB1
contributes_to interleukin-23 receptor activityIL23R;IL12RB1

IL12RB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL12RB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL12RB1.

IL12A; IL12B; SNRPD3; il23a_il-12b_human

Famulski, KS; Reeve, J; et al. Kidney Transplants With Progressing Chronic Diseases Express High Levels of Acute Kidney Injury Transcripts. AMERICAN JOURNAL OF TRANSPLANTATION 13:634-644(2013).
Tang, SW; Yang, TC; et al. Nicotinamide N-methyltransferase induces cellular invasion through activating matrix metalloproteinase-2 expression in clear cell renal cell carcinoma cells. CARCINOGENESIS 32:138-145(2011).
IL
  • Q&As
  • Reviews

Q&As (10)

Ask a question
Could you explain the significance of CRISPR/Cas9-mediated gene tagging in tracking IL12RB1 localization? 09/18/2021

Gene tagging allows real-time tracking of IL12RB1 subcellular localization.

Can you elaborate on the use of RNA-seq analysis to profile gene expression changes upon IL12RB1 activation? 07/02/2021

RNA-seq profiles gene expression changes upon IL12RB1 activation.

What are the applications of ChIP-seq in exploring IL12RB1's role in gene regulation? 01/23/2021

ChIP-seq investigates IL12RB1's impact on gene regulation networks.

What methods can be employed to assess IL12RB1 dimerization and its effect on downstream signaling? 06/13/2020

Crosslinking and immunoprecipitation assess IL12RB1 dimerization and signaling.

What techniques are suitable for studying IL12RB1's interaction with IL12A and IL23A? 02/14/2020

Co-immunoprecipitation and ELISA assay IL12RB1 interactions with cytokines.

How can the role of IL12RB1 in signal transduction be elucidated using knockdown experiments? 12/27/2019

Knockdown experiments reveal IL12RB1's contribution to signal transduction.

What are the advantages of using siRNA screening to identify IL12RB1-regulated pathways? 02/22/2019

siRNA screening identifies pathways influenced by IL12RB1 expression.

How do co-crystallization studies aid in understanding the molecular details of IL12RB1 interactions? 01/02/2019

Co-crystallization offers structural insights into IL12RB1 interactions.

How does flow cytometry provide insights into IL12RB1 expression levels on different cell types? 10/26/2018

Flow cytometry quantifies IL12RB1 levels on diverse cell populations.

What experimental approaches validate IL12RB1's involvement in cytokine-mediated immune responses? 06/25/2018

Functional assays validate IL12RB1's role in immune responses.

Customer Reviews (3)

Write a review
Reviews
04/06/2022

    Reliable in co-immunoprecipitation.

    10/18/2021

      Effective in asthma models.

      12/21/2017

        great in Western blot analysis.

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