Recombinant Human Interleukin 12 Receptor, Beta 1

• Cat.No.: IL12RB1-1649H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: Interleukin 12 receptor, beta 1 (IL12RB1) also known as CD212 (cluster of differentiation 212) is a subunit of the interleukin 12 receptor. IL12RB1 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. IL-12 Rβ1 defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species.
• State Of Matter: Lyophilized.
• Purity: >95% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-12 Rβ1 is Mr 84.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: IL12RB1 interleukin 12 receptor, beta 1 [ Homo sapiens ]
• Synonyms: interleukin 12 receptor, beta 1; CD212; IL12RB; MGC34454; IL-12R-BETA1; IL12RB1; IL-12 receptor beta component; interleukin-12 receptor beta-1 chain; IL-12R-beta-1; IL-12RB1; IL12R; CD212 antigen; Interleukin-12 receptor beta
• Gene ID: 3594
• mRNA Refseq: NM_005535
• Protein Refseq: NP_005526
• MIM: 601604
• UniProt ID: P42701
• Chromosome Location: 19p13.1
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: cytokine receptor activity