Recombinant Human Interleukin 12 Receptor, Beta 1
Cat.No. : | IL12RB1-1649H |
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Cat. No. : | IL12RB1-1649H |
Description : | Interleukin 12 receptor, beta 1 (IL12RB1) also known as CD212 (cluster of differentiation 212) is a subunit of the interleukin 12 receptor. IL12RB1 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. IL-12 Rβ1 defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-12 Rβ1 is Mr 84.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110 kDa. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Tag : | Non |
Gene Name : | IL12RB1 interleukin 12 receptor, beta 1 [ Homo sapiens ] |
Synonyms : | interleukin 12 receptor, beta 1; CD212; IL12RB; MGC34454; IL-12R-BETA1; IL12RB1; IL-12 receptor beta component; interleukin-12 receptor beta-1 chain; IL-12R-beta-1; IL-12RB1; IL12R; CD212 antigen; Interleukin-12 receptor beta |
Gene ID : | 3594 |
mRNA Refseq : | NM_005535 |
Protein Refseq : | NP_005526 |
MIM : | 601604 |
UniProt ID : | P42701 |
Chromosome Location : | 19p13.1 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway |
Function : | cytokine receptor activity |
Products Types
◆ Recombinant Protein | ||
Il12rb1-1238M | Recombinant Mouse Il12rb1 Protein, MYC/DDK-tagged | +Inquiry |
IL12RB1-6332H | Recombinant Human IL12RB1 protein, hFc-Avi-tagged | +Inquiry |
Il12rb1-10576M | Recombinant Mouse Il12rb1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL12RB1-074H | Recombinant Human IL12RB1 Protein, His-tagged | +Inquiry |
IL12RB1-4306H | Recombinant Human IL12RB1 protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL12RB1-2188HCL | Recombinant Human IL12RB1 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewReliable in co-immunoprecipitation.
Effective in asthma models.
great in Western blot analysis.
Q&As (10)
Ask a questionGene tagging allows real-time tracking of IL12RB1 subcellular localization.
RNA-seq profiles gene expression changes upon IL12RB1 activation.
ChIP-seq investigates IL12RB1's impact on gene regulation networks.
Crosslinking and immunoprecipitation assess IL12RB1 dimerization and signaling.
Co-immunoprecipitation and ELISA assay IL12RB1 interactions with cytokines.
Knockdown experiments reveal IL12RB1's contribution to signal transduction.
siRNA screening identifies pathways influenced by IL12RB1 expression.
Co-crystallization offers structural insights into IL12RB1 interactions.
Flow cytometry quantifies IL12RB1 levels on diverse cell populations.
Functional assays validate IL12RB1's role in immune responses.
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