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Recombinant Human Interleukin 12 Receptor, Beta 1

Cat.No. : IL12RB1-1649H
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Cat. No. : IL12RB1-1649H
Description : Interleukin 12 receptor, beta 1 (IL12RB1) also known as CD212 (cluster of differentiation 212) is a subunit of the interleukin 12 receptor. IL12RB1 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. IL-12 Rβ1 defect is generally associated with selective susceptibility to weakly pathogenic mycobacteria and Salmonella species.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human IL-12 Rβ1 is Mr 84.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 110 kDa.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Tag : Non
Gene Name : IL12RB1 interleukin 12 receptor, beta 1 [ Homo sapiens ]
Synonyms : interleukin 12 receptor, beta 1; CD212; IL12RB; MGC34454; IL-12R-BETA1; IL12RB1; IL-12 receptor beta component; interleukin-12 receptor beta-1 chain; IL-12R-beta-1; IL-12RB1; IL12R; CD212 antigen; Interleukin-12 receptor beta
Gene ID : 3594
mRNA Refseq : NM_005535
Protein Refseq : NP_005526
MIM : 601604
UniProt ID : P42701
Chromosome Location : 19p13.1
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function : cytokine receptor activity

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Customer Reviews (3)

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Reviews
04/06/2022

    Reliable in co-immunoprecipitation.

    10/18/2021

      Effective in asthma models.

      12/21/2017

        great in Western blot analysis.

        Q&As (10)

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        Could you explain the significance of CRISPR/Cas9-mediated gene tagging in tracking IL12RB1 localization? 09/18/2021

        Gene tagging allows real-time tracking of IL12RB1 subcellular localization.

        Can you elaborate on the use of RNA-seq analysis to profile gene expression changes upon IL12RB1 activation? 07/02/2021

        RNA-seq profiles gene expression changes upon IL12RB1 activation.

        What are the applications of ChIP-seq in exploring IL12RB1's role in gene regulation? 01/23/2021

        ChIP-seq investigates IL12RB1's impact on gene regulation networks.

        What methods can be employed to assess IL12RB1 dimerization and its effect on downstream signaling? 06/13/2020

        Crosslinking and immunoprecipitation assess IL12RB1 dimerization and signaling.

        What techniques are suitable for studying IL12RB1's interaction with IL12A and IL23A? 02/14/2020

        Co-immunoprecipitation and ELISA assay IL12RB1 interactions with cytokines.

        How can the role of IL12RB1 in signal transduction be elucidated using knockdown experiments? 12/27/2019

        Knockdown experiments reveal IL12RB1's contribution to signal transduction.

        What are the advantages of using siRNA screening to identify IL12RB1-regulated pathways? 02/22/2019

        siRNA screening identifies pathways influenced by IL12RB1 expression.

        How do co-crystallization studies aid in understanding the molecular details of IL12RB1 interactions? 01/02/2019

        Co-crystallization offers structural insights into IL12RB1 interactions.

        How does flow cytometry provide insights into IL12RB1 expression levels on different cell types? 10/26/2018

        Flow cytometry quantifies IL12RB1 levels on diverse cell populations.

        What experimental approaches validate IL12RB1's involvement in cytokine-mediated immune responses? 06/25/2018

        Functional assays validate IL12RB1's role in immune responses.

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