• Official Full Name

    interleukin 1 receptor, type II

  • Overview

    The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.
  • Synonyms

    IL1R2; interleukin 1 receptor, type II; IL1RB; interleukin-1 receptor type 2; CD121b; IL1 Receptor II; Antigen CDw121b; CD121; CD121 antigen-like family member B; CD121B Antigen; CDw121b; IL-1R-2; IL-1R-beta; IL-1R2; IL-1RT-2; IL-1RT2; IL1R Beta; Il1r-2; IL1R2_HUMAN; Interleukin 1 receptor, beta, type II; Interleukin-1 receptor beta; Interleukin-1 receptor type II; MGC137383; MGC47725; OTTHUMP00000207969; p68; Type II interleukin-1 receptor, beta; OTTHUMP00000161283; OTTHUMP00000207968; type II interl;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • C
  • Fc
  • hFc
  • His
  • His(C
  • ter)
  • Flag
  • His (Fc)
  • Avi
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL1R2-121H Active Recombinant Human IL1R2, HIgG1 Fc-tagged CHO Fc
Human IL1R2-2200H Active Recombinant Human IL1R2 protein, His-tagged HEK293 His Met 1-Glu 343
Human IL1R2-120H Active Recombinant Human IL1R2, MIgG2a Fc-tagged CHO Fc
Human IL1R2-1263H Acitve Recombinant Human IL1R2 protein(Met1-Glu343), hFc-tagged HEK293 C-hFc Met1-Glu343
Human IL1R2-1035H Recombinant Human IL1R2 protein(Met1-Glu343) HEK293 N/A Met1-Glu343
Human IL1R2-773H Recombinant Human IL1R2 protein, Fc-tagged HEK293 human/IgG1/Fc Phe14-Glu343
Human IL1R2-474H Recombinant Human IL1R2, DDDDK tagged Human Cell His
Human IL1R2-1641H Recombinant Human Interleukin 1 Receptor, Type II Sf21 Insect Cell N/A
Human IL1R2-1108HCL Recombinant Human IL1R2 cell lysate Human Cell N/A
Human IL1R2-307H Recombinant Human IL1R2 Protein, Fc-tagged HEK293 Fc 398
Human IL1R2-816H Recombinant Human IL1R2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL1R2-166H Recombinant Human IL1R2 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Met1-Glu343
Human IL1R2-1821H Recombinant Human IL1R2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IL1R2-1247H Active Recombinant Human IL1R2 protein, hFc&His-tagged HEK293 hFc&His Met1-Glu343
Human IL1R2-4406H Recombinant Human IL1R2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL1R2-2845HFL Recombinant Full Length Human IL1R2, Flag-tagged Mamanlian cells Flag
Human IL1R2-1669H Recombinant Human IL1R2 Protein, His&GST-tagged E.coli N-His&GST Phe14-Ala355
Human IL1R2-5167H Recombinant Human IL1R2 Protein (Met1-Glu343), C-His tagged Mammalian cells C-His Met1-Glu343
Human IL1R2-165H Recombinant Human IL1R2 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Met1-Glu343
Human IL1R2-306H Recombinant Human IL1R2 Protein, His-tagged HEK293 His 398
Mouse Il1r2-8699M Active Recombinant Mouse Il1r2 protein(Met1-Glu355), hFc-tagged HEK293 C-hFc Met1-Glu355
Mouse Il1r2-8700M Active Recombinant Mouse Il1r2 protein(Met1-Glu355), His-tagged HEK293 C-His Met1-Glu355
Mouse Il1r2-1754M Recombinant Mouse Interleukin 1 Receptor, Type II Sf21 Insect Cell N/A
Mouse IL1R2-1376MCL Recombinant Mouse IL1R2 cell lysate Human Cell N/A
Mouse Il1r2-5703M Recombinant Mouse Il1r2 Protein (Phe14-Glu355), C-His tagged Mammalian cells C-His Phe14-Glu355
Mouse Il1r2-5702M Recombinant Mouse Il1r2 Protein (Phe14-Glu355), C-Fc tagged Mammalian cells C-Fc Phe14-Glu355
Mouse Il1r2-1242M Recombinant Mouse Il1r2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Il1r2-1670M Recombinant Mouse Il1r2 Protein, His-tagged E.coli N-His Phe14-Pro247
Rat Il1r2-7455R Recombinant Rat Il1r2 protein(Met1-Glu355), His-tagged HEK293 C-His Met1-Glu355
Rat Il1r2-8737R Recombinant Rat Il1r2, Fc tagged Human Cell Fc
Rat IL1R2-3033R Recombinant Rat IL1R2 Protein Mammalian Cell His
Rat IL1R2-1302RCL Recombinant Rat IL1R2 cell lysate Human Cell N/A
Rat IL1R2-2688R-B Recombinant Rat IL1R2 Protein Pre-coupled Magnetic Beads HEK293
Rat IL1R2-2688R Recombinant Rat IL1R2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canine IL1R2-170C Recombinant Canine IL1R2 Protein, hFc-tagged HEK293 C-hFc Met1-Glu343
Canine IL1R2-834CCL Recombinant Canine IL1R2 cell lysate Human Cell N/A
Canine IL1R2-2178C Active Recombinant Canine IL1R2 protein, hFc-tagged HEK293 hFc Met1-Glu343
Cynomolgus IL1R2-8834C Active Recombinant Cynomolgus IL1R2 protein, hFc-tagged HEK293 hFc Met1-Glu343
Cynomolgus Monkey IL1R2-1227CCL Recombinant Cynomolgus IL1R2 cell lysate Human Cell N/A
Homo sapiens (Human) RFL23534HF Recombinant Full Length Human Interleukin-1 Receptor Type 2(Il1R2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (14-398)
Mus musculus (Mouse) RFL5526MF Recombinant Full Length Mouse Interleukin-1 Receptor Type 2(Il1R2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (14-410)
Rattus norvegicus (Rat) RFL13892RF Recombinant Full Length Rat Interleukin-1 Receptor Type 2(Il1R2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (14-416)
Rhesus Macaque IL1R2-2240R Recombinant Rhesus monkey IL1R2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL1R2-2061R-B Recombinant Rhesus Macaque IL1R2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL1R2-2061R Recombinant Rhesus Macaque IL1R2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Il1r2 Related Signal Pathway

Il1r2 involved in several pathways and played different roles in them. We selected most pathways Il1r2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1r2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionPRL2;IFNA4;VEGFB;CCL24;IFNGR1;TNFRSF18;KITB;CLCF1;CCL25
Hematopoietic cell lineageITGA3;IL4;IL2RA;CD1D2;IL3;ITGA1;GM2002;IL6;CD8B1
Transcriptional misregulation in cancerHIST1H3G;ITGAM;RXRG;ID2;NUPR1;Bcl2a1b;MAX;CCNA1;SPINT1

Il1r2 has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-1, Type II, blocking receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1r2 itself. We selected most functions Il1r2 had, and list some proteins which have the same functions with Il1r2. You can find most of the proteins on our site.

Function Related Protein
interleukin-1 receptor activityIL18R1;IL1RL1;IL1R2;IL1RAPL1A;IL1RAP;IL1RAPL2;IL1RL2;IL1R1
interleukin-1, Type II, blocking receptor activityIL1R2;IL1RAPL2
protein bindingEIF4EBP3L;MYO10;ATP6V1E2;ASB7;ZBTB16;SCRT1;HP;DDOST;SNX11

Il1r2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1r2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1r2.

IL1RAP; IL1A; Adam17; yqhH

Gene Family


Research Area

Related articles

Nakamura, Y; Sato, K; et al. Dectin-2 Deficiency Promotes Th2 Response and Mucin Production in the Lungs after Pulmonary Infection with Cryptococcus neoformans. INFECTION AND IMMUNITY 83:671-681(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review

    High specificity.


      Good for flow cytometry.


        Suitable for co-immunoprecipitation.

        Q&As (10)

        Ask a question
        What are the functional implications of IL1R2's intracellular domain, and how can engineered receptor constructs shed light on its contributions? 07/14/2021

        The intracellular domain of IL1R2 has functional significance; engineered constructs clarify its role.

        How does IL1R2's glycosylation affect its interaction with IL-1 ligands, and how can glycoproteomics methods elucidate these glycosylation sites? 04/29/2021

        Glycosylation of IL1R2 affects its IL-1 ligand interaction, and glycoproteomics methods can reveal critical glycosylation sites.

        In what ways can engineered IL1R2 variants with altered domains provide insights into its molecular mechanisms and potential therapeutic applications? 01/29/2021

        Engineered IL1R2 variants offer insights into its mechanisms and therapeutic potential.

        In what ways does IL1R2's presence influence the downstream signaling of IL-1 ligands through its competition with IL1R1, and how can genetic manipulation techniques help unravel this interplay? 01/04/2020

        IL1R2's presence impacts IL-1 ligand signaling through competition with IL1R1; genetic manipulations unveil this interaction.

        How do post-translational modifications, particularly ubiquitination, influence IL1R2's stability and turnover? 05/28/2019

        Post-translational modifications, including ubiquitination, influence IL1R2's stability.

        How does IL1R2's expression respond to inflammatory cues, and what role do transcription factors play in its regulatory network? 03/14/2019

        IL1R2 expression responds to inflammation; transcription factors play a role in its regulation.

        What insights can super-resolution microscopy offer regarding IL1R2's intracellular trafficking and subcellular localization dynamics? 01/06/2019

        Super-resolution microscopy helps understand IL1R2's trafficking and subcellular dynamics in detail.

        What specific structural features of IL1R2 enable it to function as a decoy receptor, and how can X-ray crystallography provide a detailed understanding of its ligand binding mechanisms? 10/09/2018

        Specific structural elements of IL1R2 contribute to its decoy role; X-ray crystallography provides insights into ligand binding.

        How does the shedding of IL1R2's ectodomain contribute to its role as a soluble decoy receptor, and which enzymes are involved in this process? 01/28/2018

        Ectodomain shedding contributes to IL1R2's soluble decoy role; specific enzymes are involved.

        What significance does IL1R2's interaction with IL-1 receptor accessory proteins hold in terms of its decoy function? 06/05/2016

        IL1R2's interaction with accessory proteins is significant for its decoy function.

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