Il1r2
-
Official Full Name
interleukin 1 receptor, type II -
Overview
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. -
Synonyms
IL1R2;interleukin 1 receptor, type II;IL1RB;interleukin-1 receptor type 2;CD121b;IL1 Receptor II;Antigen CDw121b;CD121;CD121 antigen-like family member B;CD121B Antigen;CDw121b;IL-1R-2;IL-1R-beta;IL-1R2;IL-1RT-2;IL-1RT2;IL1R Beta;Il1r-2;IL1R2_HUMAN;Interleukin 1 receptor, beta, type II;Interleukin-1 receptor beta;Interleukin-1 receptor type II;MGC137383;MGC47725;OTTHUMP00000207969;p68;Type II interleukin-1 receptor, beta;OTTHUMP00000161283;OTTHUMP00000207968;type II interl
Recombinant Proteins
- Human
- Cynomolgus
- Canine
- Mouse
- Rhesus macaque
- Rat
- Mus musculus
- HEK293
- CHO
- Sf21 Cells
- Mammalian Cells
- Human Cells
- E.coli
- His
- Fc
- Non
- DDK
- Myc
- GST
- Avi
- Flag
Involved Pathway
Il1r2 involved in several pathways and played different roles in them. We selected most pathways Il1r2 participated on our site, such as MAPK signaling pathway,Cytokine-cytokine receptor interaction,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1r2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hematopoietic cell lineage | IL4,DNTT,IL7R,IL5RA,CSF3,CD1d1,CD1E,GP1BB,GP9,ITGA5 |
| Cytokine-cytokine receptor interaction | PPBP,TGFBR1B,IL11RA,TNFRSF14,Ccl9,IFNA14,IL10RB,ACVR2B,Ifna15,PF4 |
| Transcriptional misregulation in cancer | FLI1,SIN3A,PLAU,RUNX1,SSX1,MLLT3,SLC45A3,BCL2A1A,SMAD1,WHSC1 |
| HTLV-I infection | HLA-G,TNFRSF1A,WNT7B,NFKB1,POLD1,ETS2,TNFRSF13C,FZD7,FZD2,PIK3R3 |
| Amoebiasis | LAMB1,PIK3CD,LAMA4,ARG2,PLCB1,VCL,COL5A1,MUC2,PRKACG,CD14 |
| MAPK signaling pathway | MAPK1,RAC1A,CACNA2D1,MAP3K7,AKT2L,MAP3K6,HSPA1B,HSPA1A,MYCB,MAP2K3 |
Protein Function
Il1r2 has several biochemical functions, for example, interleukin-1 receptor activity,interleukin-1, Type II, blocking receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1r2 itself. We selected most functions Il1r2 had, and list some proteins which have the same functions with Il1r2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HAT1,ZBTB7B,JAG2,BCL7A,SCO1,EPN1,Icosl,RPL27A,NDP,E2F5 |
| interleukin-1, Type II, blocking receptor activity | IL1RAPL2 |
| interleukin-1 receptor activity | IL1RAPL2,IL1R1,IL1RL1,IL1RL2,IL1RAP,IL18R1,IL1RAPL1A |
Interacting Protein
Il1r2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1r2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1r2.
IL1RAP;IL1A;Adam17;yqhH
Il1r2 Related Signal Pathway
Resources
Research Area
NeuroinflammationInflammatory Mediators
Macrophage Marker CD Antigen
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
Inflammatory Bowel Diseases Therapeutic Targets
Rheumatoid arthritis Therapeutic Targets
IL-1 Family Receptors
Related Services
Related Products
References
- Nakamura, Y; Sato, K; et al. Dectin-2 Deficiency Promotes Th2 Response and Mucin Production in the Lungs after Pulmonary Infection with Cryptococcus neoformans. INFECTION AND IMMUNITY 83:671-681(2015).
- Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).
