Il1r2 Protein


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Official Full Name interleukin 1 receptor, type II
Background The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.
Synonyms IL1R2; interleukin 1 receptor, type II; IL1RB; interleukin-1 receptor type 2; CD121b; IL1 Receptor II; Antigen CDw121b; CD121; CD121 antigen-like family member B; CD121B Antigen; CDw121b; IL-1R-2; IL-1R-beta; IL-1R2; IL-1RT-2; IL-1RT2; IL1R Beta; Il1r-2; IL1R2_HUMAN; Interleukin 1 receptor, beta, type II; Interleukin-1 receptor beta; Interleukin-1 receptor type II; MGC137383; MGC47725; OTTHUMP00000207969; p68; Type II interleukin-1 receptor, beta; OTTHUMP00000161283; OTTHUMP00000207968; type II interl
    • Species :
    • Canine
    • Cynomolgus Monkey
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Rat
    • Rattus norvegicus (Rat)
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293T
    • Human Cell
    • Mamanlian cells
    • Mammalian Cell
    • Sf21 Insect Cell
    • Tag :
    • Fc
    • Fc-His(C-ter)
    • Flag
    • His
    • His(C-ter)
    • human
    • IgG1
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    • N-His&GST
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL1R2-120H Recombinant Human IL1R2, MIgG2a Fc-tagged CHO Fc
    Human IL1R2-121H Recombinant Human IL1R2, HIgG1 Fc-tagged CHO Fc
    Human IL1R2-1641H Recombinant Human Interleukin 1 Receptor, Type II Sf21 Insect Cell N/A
    Human IL1R2-2200H Recombinant Human IL1R2 protein, His-tagged HEK293 His
    Human IL1R2-474H Recombinant Human IL1R2, DDDDK tagged Human Cell His
    Human IL1R2-773H Recombinant Human IL1R2 protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Il1r2-1754M Recombinant Mouse Interleukin 1 Receptor, Type II Sf21 Insect Cell N/A
    Mouse Il1r2-8699M Recombinant Mouse Il1r2, Fc tagged Human Cell Fc
    Mouse Il1r2-8700M Recombinant Mouse Il1r2, His tagged Human Cell His
    Rat IL1R2-3033R Recombinant Rat IL1R2 Protein Mammalian Cell His
    Rat Il1r2-7455R Recombinant Rat Il1r2, His tagged Human Cell His
    Rat Il1r2-8737R Recombinant Rat Il1r2, Fc tagged Human Cell Fc
    Cynomolgus Monkey IL1R2-8834C Recombinant Cynomolgus IL1R2, Fc tagged Human Cell Fc
    Rhesus Macaque IL1R2-2240R Recombinant Rhesus monkey IL1R2 Protein, His-tagged Mammalian Cell His
    Canine IL1R2-170C Recombinant Canine IL1R2, Fc tagged Human Cell His
    Human IL1R2-1108HCL Recombinant Human IL1R2 cell lysate Human Cell N/A
    Mouse IL1R2-1376MCL Recombinant Mouse IL1R2 cell lysate Human Cell N/A
    Rat IL1R2-1302RCL Recombinant Rat IL1R2 cell lysate Human Cell N/A
    Cynomolgus Monkey IL1R2-1227CCL Recombinant Cynomolgus IL1R2 cell lysate Human Cell N/A
    Canine IL1R2-834CCL Recombinant Canine IL1R2 cell lysate Human Cell N/A
    Human IL1R2-165H Recombinant Human IL1R2 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
    Human IL1R2-1669H Recombinant Human IL1R2 Protein, His&GST-tagged E.coli N-His&GST
    Human IL1R2-166H Recombinant Human IL1R2 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter)
    Mouse Il1r2-1670M Recombinant Mouse Il1r2 Protein, His-tagged E.coli N-His
    Human IL1R2-2845HFL Recombinant Full Length Human IL1R2, Flag-tagged Mamanlian cells Flag
    Rattus norvegicus (Rat) RFL13892RF Recombinant Full Length Rat Interleukin-1 Receptor Type 2(Il1R2) Protein, His-Tagged E.coli expression system His
    Homo sapiens (Human) RFL23534HF Recombinant Full Length Human Interleukin-1 Receptor Type 2(Il1R2) Protein, His-Tagged E.coli expression system His
    Mus musculus (Mouse) RFL5526MF Recombinant Full Length Mouse Interleukin-1 Receptor Type 2(Il1R2) Protein, His-Tagged E.coli expression system His
    Human IL1R2-1821H Recombinant Human IL1R2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL1R2-4406H Recombinant Human IL1R2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IL1R2-816H Recombinant Human IL1R2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Il1r2-1242M Recombinant Mouse Il1r2 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    Il1r2 involved in several pathways and played different roles in them. We selected most pathways Il1r2 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1r2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK12A; MAP2K2; JIP1; PPP3CCB; FGF6; MAP2K2A; FOS; NRAS; MAP2K5; CACNG1A
    Cytokine-cytokine receptor interaction CSF2RA; CCR8; IFNA10; MET; BMPR2B; CCL22; TGFBR1A; LTA; IL12RB1; CXCL6
    Hematopoietic cell lineage GP5; EPOR; ITGA4; CD1E, B2M; HLA-DRB4; ANPEP; IL1R2; IL6; GP1BA; IL6R
    Amoebiasis RAB7A; IL1B2; RAB7; Casp3; PIK3CG; COL4A4; IL12B; C8A; RELA; GNA14
    Transcriptional misregulation in cancer SIN3A; BMI1; SMAD1; ARNT2; HIST3H3; PROM1; SSX1; MLLT1; BCL2L1; MET

    Il1r2 has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-1, Type II, blocking receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1r2 itself. We selected most functions Il1r2 had, and list some proteins which have the same functions with Il1r2. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-1 receptor activity IL1RL2; IL1RAP; IL1RL1; IL1R1; IL1RAPL1A; IL1R2; IL18R1; IL1RAPL2
    interleukin-1, Type II, blocking receptor activity IL1RAPL2; IL1R2
    protein binding SNRNP25; GIMAP7; SNX27; FOXRED2; HSPA4L; VAMP8; PRKCI; SDCCAG3; BCOR; SPG20

    Il1r2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1r2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1r2.

    IL1RAP; IL1A; Adam17; yqhH

    Nakamura, Y; Sato, K; et al. Dectin-2 Deficiency Promotes Th2 Response and Mucin Production in the Lungs after Pulmonary Infection with Cryptococcus neoformans. INFECTION AND IMMUNITY 83:671-681(2015).
    Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).


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