Recombinant Human IL1R2 Protein, His&GST-tagged
Cat.No. : | IL1R2-1669H |
Product Overview : | Recombinant Human IL1R2 Protein (Phe14-Ala355) with N-His&GST tag was expressed in E. coli. |
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Description : | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. |
Source : | E. coli |
Species : | Human |
Tag : | His&GST |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 69 kDa Accurate Molecular Mass: 69 kDa |
Protein length : | Phe14-Ala355 |
Purity : | > 90% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in PBS or others. |
Gene Name : | IL1R2 interleukin 1 receptor, type II [ Homo sapiens (human) ] |
Official Symbol : | IL1R2 |
Synonyms : | IL1R2; interleukin 1 receptor, type II; IL1RB; interleukin-1 receptor type 2; CD121b; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2; IL-1R-beta; antigen CDw121b; IL-1 type II receptor; interleukin-1 receptor beta; interleukin-1 receptor type II; CD121 antigen-like family member B; type II interleukin-1 receptor, beta; MGC47725; |
Gene ID : | 7850 |
mRNA Refseq : | NM_004633 |
Protein Refseq : | NP_004624 |
MIM : | 147811 |
UniProt ID : | P27930 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewHigh specificity.
Good for flow cytometry.
Suitable for co-immunoprecipitation.
Q&As (10)
Ask a questionThe intracellular domain of IL1R2 has functional significance; engineered constructs clarify its role.
Glycosylation of IL1R2 affects its IL-1 ligand interaction, and glycoproteomics methods can reveal critical glycosylation sites.
Engineered IL1R2 variants offer insights into its mechanisms and therapeutic potential.
IL1R2's presence impacts IL-1 ligand signaling through competition with IL1R1; genetic manipulations unveil this interaction.
Post-translational modifications, including ubiquitination, influence IL1R2's stability.
IL1R2 expression responds to inflammation; transcription factors play a role in its regulation.
Super-resolution microscopy helps understand IL1R2's trafficking and subcellular dynamics in detail.
Specific structural elements of IL1R2 contribute to its decoy role; X-ray crystallography provides insights into ligand binding.
Ectodomain shedding contributes to IL1R2's soluble decoy role; specific enzymes are involved.
IL1R2's interaction with accessory proteins is significant for its decoy function.
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