Interleukin-23 (IL-23) is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit). IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation. Knockout mice deficient in either p40 or p19, or in either subunit of the IL-23 receptor (IL-23R and IL12R-β1) develop less severe symptoms of multiple sclerosis and inflammatory bowel disease highlighting the importance of IL-23 in the inflammatory pathway.
IL23A involved in several pathways and played different roles in them. We selected most pathways IL23A participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL23A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
IL23A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by IL23A itself. We selected most functions IL23A had, and list some proteins which have the same functions with IL23A. You can find most of the proteins on our site.
IL23A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL23A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL23A.
Masaki, K; Suzuki, Y; et al. Dual Role of Interleukin-23 in Epicutaneously-Sensitized Asthma in Mice. ALLERGOLOGY INTERNATIONAL 63:13-22(2014).
Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).