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Official Full Name IQ motif containing B1
Background This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants.
Synonyms IQCB1; IQ motif containing B1; IQ calmodulin binding motif containing 1; IQ calmodulin-binding motif-containing protein 1; KIAA0036; nephrocystin 5; NPHP5; IQ calmodulin binding motif containing protein 1; IQ calmodulin-binding motif containing 1; p53 and DNA damage-regulated IQ motif protein; PIQ; SLSN5
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IQCB1-5071H Recombinant Human IQCB1 Protein, GST-tagged Wheat Germ GST
    Human IQCB1-868HCL Recombinant Human IQCB1 cell lysate N/A
    Mouse IQCB1-8271M Recombinant Mouse IQCB1 Protein Mammalian Cell His
    Zebrafish IQCB1-1911Z Recombinant Zebrafish IQCB1 Mammalian Cell His

    iqcb1 involved in several pathways and played different roles in them. We selected most pathways iqcb1 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with iqcb1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Anchoring of the basal body to the plasma membrane CC2D2A; DCTN2; CEP76; CP110; CDK5RAP2; IQCB1; NDE1; CEP89; CEP57; NPHP1
    Assembly of the primary cilium NINL; KIF3A; EXOC8; DYNLRB1; CEP57; KIF17; IFT-20; EXOC3; HAUS2; EXOC6
    Organelle biogenesis and maintenance DYNLL2A; MRPL44; CYS1; MKKS; MRPL53; IFT-20; DYF-1; MRPL47; TRIP11; TMEM216

    iqcb1 has several biochemical functions, for example, calmodulin binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by iqcb1 itself. We selected most functions iqcb1 had, and list some proteins which have the same functions with iqcb1. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding PPP3CA; SPA17; DAPK1; STRN; EPB41B; MYH11; CAMSAP1; KCNN1B; ADD1; CNN3A
    enzyme binding THRB; SCARB2; TSPAN33; HDAC1; CD4; HOXA9; HAND1; SPDL1; PYCARD; STC2
    protein binding GJA4; PAF1; MAGEE1; SERP1; MLPH; SART1; ZNF785; RPL4; XPO5; HCST

    iqcb1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with iqcb1 here. Most of them are supplied by our site. Hope this information will be useful for your research of iqcb1.

    CALM1; parE; PCP4L1; b4drt3_human; Cep290; MYO1C; CDIPT; CPLX1; PSMA7; GEMIN2; SEC16A; CEP290; ERC2; ANGPT2; IRAK2; XPOT; CALU; GPC4; DDAH1

    Coppieters, F; Van Schil, K; et al. Identity-by-descent-guided mutation analysis and exome sequencing in consanguineous families reveals unusual clinical and molecular findings in retinal dystrophy. GENETICS IN MEDICINE 16:671-680(2014).
    de Miguel, FJ; Sharma, RD; et al. Identification of Alternative Splicing Events Regulated by the Oncogenic Factor SRSF1 in Lung Cancer. CANCER RESEARCH 74:1105-1115(2014).

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