IRF2
-
Official Full Name
interferon regulatory factor 2 -
Overview
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008] -
Synonyms
IRF2;interferon regulatory factor 2;IRF-2
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Chicken
- Mouse
- Mammalian Cells
- E.coli
- Sf9 Cells
- HEK293
- In Vitro Cell Free System
- His
- Flag
- Non
- Avi
- Fc
- DDK
- Myc
- GST
Involved Pathway
IRF2 involved in several pathways and played different roles in them. We selected most pathways IRF2 participated on our site, such as Apoptosis,Cytokine Signaling in Immune system,Factors involved in megakaryocyte development and platelet production, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Innate Immune System | CFHL4,AGER,BTR18,DEFA3,CFHL3,BAIAP2,DEFB4A,SIGLEC15,DEFB129,ALCAMB |
| Cytokine Signaling in Immune system | PAQR3B,TRIM14,IFIT14,IFIT12,KPNA4,DUSP1,EIF4E,TRIM3,TNIP2,IRF6 |
| Immune System | DYNLL2,HLA-DQB2,KIF11,AP1M2,CD300LG,ARIH2,PJA1,CLEC4D,RAP1GAP2B,FCGR1B |
| Interferon alpha/beta signaling | IRF6,IRF4,IFITM3,OASL,ISG20,IFIT3,SAMHD1,XAF1,IRF9,IFI35 |
| Interferon Signaling | XAF1,EIF4G2A,IFIT2,ARIH1L,TRIM10,IFIT10,TRIM14,OASL,IFI6,HLA-DQB2 |
| Apoptosis | CFLAR,PRKACAB,CASP6L2,BID,PIK3R3B,GAS2,BAXB,IRF6,CYCSB,IRF4 |
| Hemostasis | F13A1B,SRGN,MFN1,BA2,ANXA2,BRPF3,OSTN,KIF2A,ZFPM1,ANGPT2A |
| Factors involved in megakaryocyte development and platelet production | ZFPM2A,GATA1A,GATA1,HBB-Y,KIF3A,KLC3,DOCK11,HBBE1.1,DOCK9,HMG20B |
Protein Function
IRF2 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF2 itself. We selected most functions IRF2 had, and list some proteins which have the same functions with IRF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NACA,CLOCK,ESRRGA,SET,HES1,HIST1H2BI,ZNF829,DICER1,GTF2F1,TAF12 |
| protein binding | LETMD1,SLX4,SLC4A1AP,NAE1,PYGO1,C5orf30,EPHA3,LGALS1,MFAP1,ADRA2C |
| transcription factor activity, sequence-specific DNA binding | ZNF134,ZNF215,ZNF75D,ZNF649,POU3F2A,TBX21,FOXP4,ATF4B2,JUNBA,DMRT3 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ATF4,ZIK1,PAX9,GATA2B,BARHL1A,PHOX2A,DBP,GATA5,RXRB,CREB3 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | STAT3,STAG1,REST,GATA2A,GATA4,NKX2-5,FOXC1,BARHL1A,MYOD1,RFX6 |
Interacting Protein
IRF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF2.
ATG7;PPP3CB;FOXK1;FOXK2;HSP90AB1;fliN;FKBP7;AP5Z1;HCFC1;PPP3CA;IRF2BP2;IRF2BP1;IRF2BPL;HCFC2
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