ITGA3
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Official Full Name
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
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Overview
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
ITGA3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); antigen identified by monoclonal J143 , MSK18; integrin alpha-3; CD49c; GAP B3; VCA 2; VLA3a; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal J143; very late activation protein 3 receptor, alpha-3 subunit; VL3A; GAPB3; MSK18; VCA-2; GAP-B3; FLJ34631; FLJ34704;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- His
- Flag
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ITGA3 involved in several pathways and played different roles in them. We selected most pathways ITGA3 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | CREB3L3;PIK3R5;PDGFD;PPP2R5E;TNR;IL3;PPP2R5A;FGF9;GHR |
| Focal adhesion | ITGA7;AKT2L;ACTN4;LAMA4;CDC42;FIGF;PDGFAB;MYLPF;PARVB |
| ECM-receptor interaction | LAMB1A;COL5A1;ITGB7;GP6;COL4A3;ITGA3B;GP1BA;THBS2;VTNB |
| Hematopoietic cell lineage | DNTT;ITGA1;CD1A;ITGA5;IL9R;CD1E;GP5;CD8B;CSF1R |
| Regulation of actin cytoskeleton | PIK3CB;PPP1CA;ARPC5L;F2;BRAF;GNA13A;ITGA6;PIK3CD;MYLK |
| Pathways in cancer | FGF9;KITLG;MAX;ITGA3;PDGFA;ITGA2B;SLC2A1;SMAD2;TRAF1 |
| Small cell lung cancer | ITGA3;TRAF2;BIRC2;RELA;TRAF5;LAMB4;ITGA2B;LAMA3;PIK3R1 |
| Hypertrophic cardiomyopathy (HCM) | IL6;ITGA4;IGF1;ITGA7;SGCB;CACNG3;PRKAG2;PRKAG3;ITGA5 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DSG2;CACNG1;RYR2;ITGA8;CACNG7;SLC8A1;ITGAV;TCF7L2;CTNNA1 |
| Dilated cardiomyopathy | CACNA2D1;ADRB1;SGCB;CACNA2D2;ITGA2B;ITGB8;ITGA1;ITGA10;CACNG4 |
ITGA3 has several biochemical functions, for example, collagen binding, fibronectin binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA3 itself. We selected most functions ITGA3 had, and list some proteins which have the same functions with ITGA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| collagen binding | PAK1;FN1;PCOLCE;Pdgfa&Pdgfb;HSD17B12;DCN;ASPN;NID2;ACHE |
| fibronectin binding | CTSL1;SFRP2;PLEKHA2;LPA;ITGAV;CCDC80;CTGF;IGFBP5;ITGB3 |
| glycoprotein binding | Serpina1b;Itgam&Itgb2;B2M;SELP;FYN;FGFR1;IDE;ACE2;THBS1 |
| integrin binding | TGFBI;EDIL3;CD226;S1PR2;THY1;VTN;ESM1;PXN;P4HB |
| laminin binding | ITGA9;LRRC15;PLEKHA2;ITGA3;LGALS3;ECM1;ITGB1;GPC1;TINAGL1 |
| metal ion binding | GNAT2;RNF144AB;RNF44;RXRBB;OVCH2;CTH1;UNC13B;EIF2S2;PDE1B |
| protease binding | FAP;INS1;SERPINB4;MALT1;LRP1;PANX1;TTN;HSPD1;COMP |
| protein binding | CHD4;ARAF;SLC22A5;CHRAC1;CD200R3;DOT1L;KCNB1;RNASE1;PRDM16 |
| protein domain specific binding | PLXND1;TNFAIP1;MED12;CALM2;TACC3;WHRN;IL1B;HGS;AKAP5 |
| protein heterodimerization activity | PANX1;HYPM;TPD52L1;JAM2;BNIP3;H3F3C;LIMK1;POLA1;HIST1H3D |
ITGA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA3.
PDIA3; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; gd3; cona_canen; Itgb1
Research Area
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