ITGA3

  • Official Full Name

    integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

  • Overview

    The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms

    ITGA3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); antigen identified by monoclonal J143 , MSK18; integrin alpha-3; CD49c; GAP B3; VCA 2; VLA3a; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal J143; very late activation protein 3 receptor, alpha-3 subunit; VL3A; GAPB3; MSK18; VCA-2; GAP-B3; FLJ34631; FLJ34704;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGA3-5134HCL Recombinant Human ITGA3 293 Cell Lysate HEK293 N/A
Human ITGA3-1011HFL Recombinant Full Length Human ITGA3 Protein, C-Flag-tagged Mammalian cells Flag
Human ITGA3-1209H-B Recombinant Human ITGA3 Protein Pre-coupled Magnetic Beads HEK293
Human ITGA3-52H Recombinant Human ITGA3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human ITGA3-1209H Recombinant Human ITGA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ITGA3-077H Recombinant Human ITGA3 Protein, C-His-tagged E.coli C-His
Mouse Itga3-6773M Recombinant Mouse Itga3 protein, His & T7-tagged E.coli His/T7
Mouse ITGA3-8349M Recombinant Mouse ITGA3 Protein Mammalian Cell His
Mouse Itga3-3594M Recombinant Mouse Itga3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ITGA3-4636M-B Recombinant Mouse ITGA3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ITGA3-4636M Recombinant Mouse ITGA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ITGA3-5722C Recombinant Chicken ITGA3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITGA3 Related Articles
  • ITGA3 Related Research Area

ITGA3 involved in several pathways and played different roles in them. We selected most pathways ITGA3 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayPDGFA;VEGFB;TNR;FGFR3;LPAR6;PPP2R5B;IL6;RAF1;SPP1
Focal adhesionMYL5;MAP2K1;PPP1CAB;PDGFRB;THBS1;MYLK2;THBS4;THBS4A;ITGA6B
ECM-receptor interactionNpnt;THBS3;THBS4B;SV2A;THBS3A;CD47;LAMA5;ITGA2B;COL2A1B
Hematopoietic cell lineageIL11RA2;CD14;EPO;CD1A;IL5RA;Itga10&Itgb1;ITGA5;ITGA6;CD1C
Regulation of actin cytoskeletonPIP5K1A;ITGB1A;RAC3B;FGF4;PIP5K1BB;FGF5;MYL7;GNA13A;ITGB3
Pathways in cancerF2R;CKS2;FZD2;NFKB1;Shh;VEGFB;MAP2K2;BIRC2;ETS1
Small cell lung cancerCOL4A1;FHIT;ITGB1;ITGA3;PTGS2;LAMC1;PIAS2;PIK3CB;LAMB1
Hypertrophic cardiomyopathy (HCM)LMNA;PRKAG1;ITGAV;ITGA9;CACNA2D1;MYL3;ITGA5;CACNG4;MYL2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ITGA3;CTNNA1;ITGA10;ITGB5;ITGAV;AASS;LAMA2;ITGB7;CACNG8
Dilated cardiomyopathyITGA6;ITGA8;ACTG1;TPM2;CACNA2D1;CACNG4;DES;ITGB1;ACTB

ITGA3 has several biochemical functions, for example, collagen binding, fibronectin binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA3 itself. We selected most functions ITGA3 had, and list some proteins which have the same functions with ITGA3. You can find most of the proteins on our site.

Function Related Protein
collagen bindingABI3BP;PCOLCE2;ANTXR1;RELL2;GPR56;LRRC15;ACHE;SERPINH2;TLL1
fibronectin bindingCTSK;ITGB1;PLEKHA2;CTSS;FSTL3;ITGAV;ITGA3;CCDC80;LRRC15
glycoprotein bindingFOXRED2;RAB14;SHB;THBS1;ITGA3;HFE2;PTBP3;IDE;LRRK2
integrin bindingTHY1;ICAM5;LAMA5;CTGF;PPAP2B;CYR61L1;CTGFA;VTN;WISP1A
laminin bindingACHE;ITGA9;LYPD5;TINAGL1;CTSS;GPC1;NCL;LRRC15;BCAM
metal ion bindingZNF726;PELO;DPH3;CYP2F2;MUSK;MGRN1A;ZNF225;PTGS2;ZNF75A
protease bindingCstb;ANXA2;SERPINA1;VWF;NDUFS7;UBC;CSTA;SERPINB3;TIMP2B
protein bindingGMDS;EPCAM;FHL3;LTC4S;C1orf35;HIC1;WDR20;PPP2R2A;CYHR1
protein domain specific bindingHPCAL4;SKI;CALM2;YWHAH;AKAP1;CHMP1B;MTOR;RAP2B;STRN4
protein heterodimerization activityHIST1H2AM;HIST2H2L;HMG20B;CHRNA5;H3F3A;SIM1;PKNOX1;NFYC;FLOT2

ITGA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA3.

PDIA3; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; gd3; cona_canen; Itgb1

Bauer, KM; Watts, TN; et al. Proteomic and Functional Investigation of the Colon Cancer Relapse-Associated Genes NOX4 and ITGA3. JOURNAL OF PROTEOME RESEARCH 13:4910-4918(2014).
Ren, Y; Hao, PL; et al. Hypoxia-induced Changes to Integrin alpha 3 Glycosylation Facilitate Invasion in Epidermoid Carcinoma Cell Line A431. MOLECULAR & CELLULAR PROTEOMICS 13:3126-3137(2014).
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