ITGAV
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Official Full Name
integrin, alpha V
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Overview
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V beta 3 is the predominant integrin of osteoclasts (bone resorbing cells) and is upregulated in malignant melanoma. Integrin alpha V beta 3 binds to a range of ECM proteins (e.g. vitronectin, fibrinogen, fibronectin) via an Arg-Gly-Asp (RGD) motif. -
Synonyms
ITGAV; integrin, alpha V; antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR; integrin alpha-V; CD51; integrin alphaVbeta3; vitronectin receptor s;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- Baculovirus-Insect cells
- CHO
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- 6×His
- His
- Strep
- GST
- His (Fc)
- Avi
- His|Avi
- His|T7
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ITGAVB3-103H | Active Recombinant Human ITGAVB3 | CHO | N/A | ||
Human | ITGAV&ITGB1-740H | Active Recombinant Human ITGAV&ITGB1 | CHO | N/A | ||
Human | ITGAV&ITGB6-741H | Active Recombinant Human ITGAV&ITGB6 | CHO | N/A | ||
Human | ITGAV-26862TH | Recombinant Human ITGAV protein | Wheat Germ | N/A | ||
Human | ITGA5-101H | Recombinant Human ITGAV/ITGB3 Heterodimer Protein, His-tagged | HEK293 | His | ITGAV(Phe 31 - Val 992)/ITGB3 (Gly 27 - Asp 718) | |
Human | ITGAV&ITGB3-739H | Recombinant Human ITGAV/ITGB3 protein, His-tagged | HEK293 | His | Phe 31 - Val 992 (ITGAV) & Gly 27 - Asp 718 (ITGB3) | |
Human | ITGAV-6763H | Recombinant Human ITGAV protein, His-tagged | E.coli | His | Pro560~Trp744 | |
Human | ITGAV-877HCL | Recombinant Human ITGAV cell lysate | N/A | |||
Human | ITGAV & ITGB6-760H | Active Recombinant Human ITGAV & ITGB6 Protein, His-Avi-tagged, Biotinylated | HEK293 | His/Avi | ||
Human | ITGAV & ITGB5-758H | Active Recombinant Human ITGAV & ITGB5 Protein, His-Avi-tagged, Biotinylated | HEK293 | His/Avi | ||
Human | ITGAV-4988H | Recombinant Human ITGAV Protein, GST-tagged | Wheat Germ | GST | ||
Human | ITGAV & ITGB1-746H | Active Recombinant Human ITGAV & ITGB1 protein, His-Avi-tagged, Biotinylated | HEK293 | His-Avi | Phe31-Val992(ITGAV)&Gly27-Asp718(ITGB3) | |
Human | ITGAV-26H | Active Recombinant Human ITGAV Protein, C-6×His-tagged | CHO | C-6×His | Integrin alpha V: Phe31-Val992<br />Integrin beta 1: Gln21-Asp728 | |
Human | ITGAV & ITGB5-336H | Recombinant Human ITGAV & ITGB5 protein, His-Avi-tagged | HEK293 | His-Avi | It contains Phe31-Val992 (P06756) acidic tail& Gly24-Asn719 (P18084) basic tail. | |
Human | ITGAV & ITGB3-311H | Recombinant Human ITGAV & ITGB3 protein, His-Avi-tagged | HEK293 | His-Avi | It contains Phe31-Val992 (P06756) acidic tail& GLy27-Asp718 (P05106) basic tail. | |
Human | ITGAV & ITGB3-738H | Active Recombinant Human ITGAV & ITGB3 Protein, His-Avi-tagged, Biotinylated | HEK293 | His/Avi | ||
Human | ITGAV-4323H | Recombinant Human ITGAV Protein (Met1-Val992), C-His tagged | Mammalian cells | C-His | Met1-Val992 | |
Human | ITGAV-2343H | Recombinant Human ITGAV Protein, His-tagged | E.coli | N-His | Phe31-Gly560 | |
Human | ITGAV-2775H | Recombinant Human ITGAV protein, His-tagged | E.coli | His | 819-915 aa | |
Human | ITGAV-1427H | Recombinant Human ITGAV Protein (891-1048 aa), His-tagged | Yeast | His | 891-1048 aa | |
Human | ITGAV-6962HF | Recombinant Full Length Human ITGAV Protein | In Vitro Cell Free System | 1048 amino acids | ||
Human | ITGAV-265HF | Recombinant Full Length Human ITGAV Protein | In Vitro Cell Free System | |||
Human | ITGAV-301294H | Recombinant Human ITGAV protein, GST-tagged | E.coli | GST | Ser819-Gln915 | |
Human | ITGAV-5749HF | Recombinant Full Length Human ITGAV Protein, GST-tagged | In Vitro Cell Free System | GST | 1048 amino acids | |
Mouse | ITGAV-8360M | Recombinant Mouse ITGAV Protein | Mammalian Cell | His | ||
Mouse | Itgav-6764M | Recombinant Mouse Itgav protein, His & T7-tagged | E.coli | His/T7 | Pro71~Asp322 (Accession # P43406) | |
Mouse | ITGAV-4641M-B | Recombinant Mouse ITGAV Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ITGAV-4641M | Recombinant Mouse ITGAV Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Itgav-1700R | Recombinant Rat Itgav Protein, His-tagged | E.coli | N-His | Pro469-Leu918 | |
Rat | Itgav&Itgb6-23R | Recombinant Rat Itgav&Itgb6 Protein | CHO | N/A | ||
Bovine | ITGAV-5819B | Recombinant Bovine ITGAV and ITGB6 Protein (Phe31-Pro993, Gly22-Pro709), C-His & C-Strep tagged | Mammalian cells | C-His and C-Strep | Phe31-Pro993, Gly22-Pro709 | |
Bovine | ITGAV-0032B | Recombinant Bovine ITGAV Protein (Ala30-Pro993), C-His-tagged | Baculovirus-Insect cells | C-His | Ala30-Pro993 | |
Rhesus Macaque | ITGAV-2315R | Recombinant Rhesus monkey ITGAV Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | ITGAV-2136R | Recombinant Rhesus Macaque ITGAV Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | ITGAV-2136R-B | Recombinant Rhesus Macaque ITGAV Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | ITGAV-3406Z | Recombinant Zebrafish ITGAV | Mammalian Cell | His | ||
Chicken | ITGAV-6989C | Recombinant Chicken ITGAV | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ITGAV Related Articles
- ITGAV Related Research Area
ITGAV involved in several pathways and played different roles in them. We selected most pathways ITGAV participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAV were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | LAMP2;TLR2;TUBA2;HLA-DMA;THBS4B;SEC61AL2;FCGR3;TUBB;BMA1 |
PIK-Akt signaling pathway | INSR;TCL1B1;RPS6KB1;IFNA17;IBSP;PIK3CA;GNB4;PHLPP2;IFNA16 |
Focal adhesion | ITGA7;VEGFA;COL6A2;PAK2;VEGFB;COL4A6;Reln;COL6A4;SPP1 |
ECM-receptor interaction | COL6A6;SDC4;ITGA3B;ITGA7;COL1A1A;COL1A2;LAMB2;LAMB1;ITGB1B.2 |
Cell adhesion molecules (CAMs) | PTPRF;CD40;H2-AB1;SELPLG;CD34;LRRC4;CLDN5B;CLDNH;BF2 |
Regulation of actin cytoskeleton | ARHGEF7;MYLPFA;FGF20B;PIP5K2;ITGA3B;FGF8A;INS;CD14;PIK3CB |
Thyroid hormone signaling pathway | MED12L;DIO1;SIN3A;RAF1;MAPK3;BAD;FXYD2;ATP1B3;ITGB3 |
Pathways in cancer | MECOM;Ar;ABL1;LPAR5;RXRB;CKS2;GNG5;TGFB3;RARB |
Proteoglycans in cancer | SRC;HPSE2;DDX5;PLCG2;TWIST1;WNT5A;WNT7B;PTPN11;FLNC |
Small cell lung cancer | ITGB1;LAMB3;AKT1;CKS2;PIK3R2;CCNE1;LAMA4;IKBKG;RELA |
Hypertrophic cardiomyopathy (HCM) | ITGA10;ACTG1;CACNA2D1;CACNG6;Itga10&Itgb1;ITGB1;LMNA;CACNB2;SGCB |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DES;SGCA;ITGB7;ITGAV;ITGA10;ACTN1;SGCD;CTNNA1;CACNG8 |
Dilated cardiomyopathy | TGFB2;DMD;MYBPC3;SGCD;TGFB1;CACNG4;ITGA7;ITGA8;GNAS |
ITGAV has several biochemical functions, for example, extracellular matrix binding, extracellular matrix protein binding, fibronectin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAV itself. We selected most functions ITGAV had, and list some proteins which have the same functions with ITGAV. You can find most of the proteins on our site.
Function | Related Protein |
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extracellular matrix binding | SPOCK2;SID4;SPARC;CD248;DCN;ITGB3;SPP1;GPR56;BGN |
extracellular matrix protein binding | MEPE;ITGAV;ITGB8 |
fibronectin binding | CCDC80;CTGF;SDC4;ITGB1A;ITGB1;HSD17B12;IGFBP5B;FBLN1;MFAP2 |
contributes_to insulin-like growth factor I binding | |
metal ion binding | ZFP768;ZFP36L1A;NTHL1;ZEB2B;MSS51;ZNF395A;LHX1B;MLL1;HSCB |
contributes_to opsonin binding | |
protease binding | SERPINB3;TP53;INS;TNFAIP3;TIMP2B;STIM1;IL1R1;TIMP3;SRI |
protein binding | FAM96A;ANKRD49;ZRANB1;FOXP2;FBXO7;ARHGAP44;CAV2;PSMA2;CPS1 |
contributes_to protein kinase C binding | |
transforming growth factor beta binding | TGFBR1;CD109;TGFBR3;ACVRL1;ITGAV;TGFBR2;VASN;HYAL2;TGFB3 |
virus receptor activity | ITGA5;CLEC5A;PVRL4;TYRO3;ACE2;CXADR;PVRL1;CD46;LAMP1 |
voltage-gated calcium channel activity | CACNA1SA;CACNA1SB;RYR1;CACNA2D1;CACNA1C;ATP6V0CB;CACNA1DA;CACNG6;GAS6 |
ITGAV has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAV here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAV.
ITGB3; FN1; ITGB5; PPAP2B; VTN; VWF; PTPRZ1
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