ITPK1
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Official Full Name
inositol-tetrakisphosphate 1-kinase -
Overview
Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene. -
Synonyms
ITPK1;inositol-tetrakisphosphate 1-kinase;inositol 1,3,4 triphosphate 5/6 kinase;ins(1,3,4)P(3) 5/6-kinase;inositol-triphosphate 5/6-kinase;inositol 1,3,4-triphosphate 5/6 kinase;inositol 1,3,4-trisphosphate 5/6 kinase;inositol 1,3,4-trisphosphate
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- Non
- DDK
- Myc
- Avi
- Fc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ITPK1-1351H | Recombinant Human Inositol-Tetrakisphosphate 1-kinase, His-tagged | E.coli | Human | His | 1-414aa |
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| ITPK1-1959C | Recombinant Chicken ITPK1 | Mammalian Cells | Chicken | His |
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| ITPK1-8385M | Recombinant Mouse ITPK1 Protein | Mammalian Cells | Mouse | His |
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| ITPK1-5112HCL | Recombinant Human ITPK1 293 Cell Lysate | HEK293 | Human | Non |
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| Itpk1-3619M | Recombinant Mouse Itpk1 Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| ITPK1-3757H | Recombinant Human ITPK1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| ITPK1-4652M | Recombinant Mouse ITPK1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ITPK1-4652M-B | Recombinant Mouse ITPK1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| ITPK1-5838HF | Recombinant Full Length Human ITPK1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 314 amino acids |
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| ITPK1-6743H | Recombinant Human ITPK1 protein, GST-tagged | E.coli | Human | GST | 1-314 aa |
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Involved Pathway
ITPK1 involved in several pathways and played different roles in them. We selected most pathways ITPK1 participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian),1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3),D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Factors involved in megakaryocyte development and platelet production | BA1,PHF21A,CBX5,KIFC1,DOCK8,CABLES2,DOCK10,MAFGA,KIF3B,KIF2A |
| Hemostasis | GLG1B,GATA1,CEACAM6,KIF4A,CLU,ITGB3A,CEACAM1,KIF11,ANXA2B,KIF5A |
| Inositol phosphate metabolism | PIP5K1AB,INPP5A,IPMKB,MTMR14,ALDH6A1,PI4KAA,PIK3C2G,NUDT10,TPI1B,IP6K3 |
| Metabolic pathways | ATP5D,LDHB,ALDH3B2,CKMT1A,LIAS,CELL,PET112L,EPRS,SUCLG2,PIPOX |
| 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) | ITPKB,ITPKA |
Protein Function
ITPK1 has several biochemical functions, for example, ATP binding,catalytic activity,inositol tetrakisphosphate 1-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPK1 itself. We selected most functions ITPK1 had, and list some proteins which have the same functions with ITPK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity | CTDSPL2B,CTDSPL2A,SGPP2,PTPRQ,NT5DC3,SACM1L,PXYLP1,SACM1LB,TENC1,SACM1LA |
| inositol-1,3,4-trisphosphate 6-kinase activity | ITPK1A |
| inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity | SACM1LA,CTDSPL2B,NT5DC3,SACM1L,SACM1LB,PTPRQ,SGPP2,PXYLP1,TENC1,CTDSPL2A |
| inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity | PTPRQ,SACM1LA,CTDSPL2A,SGPP2,SACM1LB,TENC1,NT5DC3,CTDSPL2B,PXYLP1,SACM1L |
| ATP binding | DDX6,PANK2,TAP2,CHD2,CSF1R,RAD50,ACVR1L,MAP4K6,FLAD1,GLULA |
| inositol-1,3,4-trisphosphate 5-kinase activity | ITPK1A |
| catalytic activity | PKM,MOXD2,GULO,ALPI.2,LGI1A,TDH2,ACSL1,ACSM2,ODZ4,AGXTA |
| magnesium ion binding | RRAGC,IDH3B,TSSK3,THG1L,MARK2,TDP2B,PKM2,MAPK12,PPM1A,PPM1AB |
| inositol tetrakisphosphate 1-kinase activity | ITPK1A |
Interacting Protein
ITPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPK1.
TRAF2;pi3p;CDC5L
Resources
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References
- Guan, Z; Wang, JH; et al. The Maternal ITPK1 Gene Polymorphism Is Associated with Neural Tube Defects in a High-Risk Chinese Population. PLOS ONE 9:-(2014).
- Porcu, E; Medici, M; et al. A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function. PLOS GENETICS 9:-(2013).
