ITPKA

  • Official Full Name

    inositol-trisphosphate 3-kinase A

  • Overview

    Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.

  • Synonyms

    ITPKA;inositol-trisphosphate 3-kinase A;inositol 1,4,5 trisphosphate 3 kinase A;IP3 3KA;IP3KA;IP3K A;IP3 3-kinase A;insP 3-kinase A;inositol 1,4,5-trisphosphate 3-kinase A;IP3-3KA

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Flag
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    ITPKA involved in several pathways and played different roles in them. We selected most pathways ITPKA participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian),Calcium signaling pathway,D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) ITPK1,ITPKB
    Metabolic pathways AANAT,ATP6V0CB,IPMK,DHCR24,CHIA,GBA3,RDH10A,INPP5K,HGSNAT,LPIN2
    Metabolism PLB1,MED25,AWAT2,MED16,FAM96B,G0S2,GGT6,YY2,PLD6,NDUFAF3
    Synthesis of IP3 and IP4 in the cytosol ITPKB,PLCD3
    Phosphatidylinositol signaling system PRKCBA,PI4K2A,DGKE,PIP5K1BB,IP6K2,PLCB3,DGKZ,PIK3C2B,IP6K3,IP6K1
    Calcium signaling pathway GNAQ,TNNC2,EDNRB2,CALM2,ADCY2B,TACR3A,PHKA2,CACNA1G,EDNRAA,SLC25A6
    Inositol phosphate metabolism PIP4K2B,PIP5K1B,PLCD1B,PLCG2,PLCD3,PTENA,PLCD1A,OCRL,PLCD3A,PLD4
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis ITPKB

    Protein Function

    ITPKA has several biochemical functions, for example, ATP binding,Rac GTPase binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKA itself. We selected most functions ITPKA had, and list some proteins which have the same functions with ITPKA. You can find most of the proteins on our site.

    Function Related Protein
    inositol-1,4,5-trisphosphate 3-kinase activity ITPKB,IP6K3,ITPKC,IP6K2,IPMKB,IPMK,IP6K1
    Rac GTPase binding MAP3K11,HACE1,ARFIP2,CORO1C,RCC2,RAB7A,DOCK7,NOX1,NCF2,SRGAP2B
    ATP binding PSMC1,SARS2,KARS,MYHZ1.1,CLK2,KIF20A,MAP2K3,ULK4,SUCLG1,ABCD4
    calmodulin binding SLC8A1,MYO6,PHKA1,DAPK2,MYO1E,NRGN,RRAD,CAMSAP1,DDX5,EEF2K
    calmodulin-dependent protein kinase activity CAMKK1,CAMK1GA,DAPK1,MAPKAPK5,PNCK,CAMK4,CAMK2D,CAMK1D,MKNK1,DAPK2A

    Interacting Protein

    ITPKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKA here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKA.

    DBN1

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