ITPKA

  • Official Full Name

    inositol-trisphosphate 3-kinase A

  • Overview

    Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.

  • Synonyms

    ITPKA;inositol-trisphosphate 3-kinase A;inositol 1,4,5 trisphosphate 3 kinase A;IP3 3KA;IP3KA;IP3K A;IP3 3-kinase A;insP 3-kinase A;inositol 1,4,5-trisphosphate 3-kinase A;IP3-3KA

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Flag
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    ITPKA involved in several pathways and played different roles in them. We selected most pathways ITPKA participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian),Calcium signaling pathway,D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway P2RX8,PTGFR,EDNRA,EDNRB,CAMK2G1,HRH2,ADCY2B,GNAQ,ADRB1,PRKACG
    Metabolism GCHFR,PAOX,CDO1,CYB5R3,PPM1LB,SLC35B2,SLC25A11,SLC25A15,MMADHC,SLC27A2A
    Inositol phosphate metabolism PLCH1,PLCD3,MTMR1B,PI4KA,INPP5K,PIK3CB,NUDT4A,MTMR1,IPPK,PLCD4
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) ITPK1,ITPKB
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis ITPKB
    Synthesis of IP3 and IP4 in the cytosol PLCD3,ITPKB
    Metabolic pathways CHIA,ATP5B,PLCG2,ALOX12E,HSD17B8,ACLY,FUT9A,UCK2A,PIGH,EXT1A
    Phosphatidylinositol signaling system INPP1,PLCZ1,DGKAA,PLCB4,PTENB,PLCD3A,PIP5K2,CALML3,MTMR1B,PIK3R1

    Protein Function

    ITPKA has several biochemical functions, for example, ATP binding,Rac GTPase binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKA itself. We selected most functions ITPKA had, and list some proteins which have the same functions with ITPKA. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin-dependent protein kinase activity PNCK,CAMK1G,DCX,MAPKAPK2A,CAMKK1,PTK2B,CAMK2B,CAMK2D2,CAMK1GB,CAMK2A
    inositol-1,4,5-trisphosphate 3-kinase activity IP6K2,ITPKC,ITPKB,IP6K3,IP6K1,IPMK,IPMKB
    Rac GTPase binding PAK6,EPS8,PKN1,SOD1,PAK1,RAB7,CORO1C,PAK4,ARFIP2,MAP3K11
    calmodulin binding CNN3B,NOS2,MIP,CAMK1D,RIT1,MAP6,CAMSAP1L1,ENKUR,OBSCN,MYO5B
    ATP binding KCNJ10,BUB1B,BCS1L,MYLK4,ATM,ERBB3B,ACTBL2,PFKMA,STK16,RTCB

    Interacting Protein

    ITPKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKA here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKA.

    DBN1

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