ITPKA

  • Official Full Name

    inositol-trisphosphate 3-kinase A

  • Overview

    Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.

  • Synonyms

    ITPKA;inositol-trisphosphate 3-kinase A;inositol 1,4,5 trisphosphate 3 kinase A;IP3 3KA;IP3KA;IP3K A;IP3 3-kinase A;insP 3-kinase A;inositol 1,4,5-trisphosphate 3-kinase A;IP3-3KA

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Flag
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    ITPKA involved in several pathways and played different roles in them. We selected most pathways ITPKA participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian),Calcium signaling pathway,D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism SYNJ1,INPP4AB,PI4K2A,PLCD3,MTMR3,INPP5B,PLCD1,PLCE1,PIP4K2AA,NUDT4B
    Synthesis of IP3 and IP4 in the cytosol ITPKB,PLCD3
    Metabolism DDAH2,LPA,TM9SF1,FAAH2B,CYB5R3,SLC25A2,FABP11B,OXSR1,SLC25A20,FAAH2
    Metabolic pathways ACAA1A,ST3GAL4,DHRS3,STT3A,FBP1A,POLR3G,CYP2P9,ALAS2,ATP6V1C1B,ACSS1
    Calcium signaling pathway PHKG1B,CHRM5A,LHCGR,GNA14,MYLK2,PTGER1B,ATP2B2,EGFRA,DRD5,PRKACB
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis ITPKB
    Phosphatidylinositol signaling system CALM2A,PIK3C2B,PRKCBA,PTENB,PPIP5K2,PPIP5K1,PRKCA,TMEM55B,CALM3A,PLCD3
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) ITPK1,ITPKB

    Protein Function

    ITPKA has several biochemical functions, for example, ATP binding,Rac GTPase binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKA itself. We selected most functions ITPKA had, and list some proteins which have the same functions with ITPKA. You can find most of the proteins on our site.

    Function Related Protein
    Rac GTPase binding FLNA,PAK7,SRGAP2,FMNL1,NOX1,DOCK7,DOCK4,CAV1,DVL1,ARFIP2
    ATP binding MAP2K7,SCYL1,VRK1,MAT2AL,PSMC1A,VSIG8B,TWF2,GART,CLCN7,CSNK1G2B
    calmodulin-dependent protein kinase activity DAPK1,NETO2,CAMK2B1,CAMK1,CAMK1GB,DCX,CAMK1D,MKNK2B,MKNK2,CAMK2B
    calmodulin binding AEBP1,UPF3B,SNTB2,REM1,MAP2,GM101,MYH4,MAPKAPK2,MYH7,RGS2
    inositol-1,4,5-trisphosphate 3-kinase activity IP6K2,ITPKB,IP6K1,IPMK,ITPKC,IP6K3,IPMKB

    Interacting Protein

    ITPKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKA here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKA.

    DBN1

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