ITPKA

  • Official Full Name

    inositol-trisphosphate 3-kinase A

  • Overview

    Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.

  • Synonyms

    ITPKA;inositol-trisphosphate 3-kinase A;inositol 1,4,5 trisphosphate 3 kinase A;IP3 3KA;IP3KA;IP3K A;IP3 3-kinase A;insP 3-kinase A;inositol 1,4,5-trisphosphate 3-kinase A;IP3-3KA

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Flag
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    ITPKA involved in several pathways and played different roles in them. We selected most pathways ITPKA participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian),Calcium signaling pathway,D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism PIK3CB,NUDT3B,MTMR1,INPPL1,ITPK1A,PLCG2,PIP5K1C,MIOX,MTMR4,ITPKC
    Calcium signaling pathway HRH2,ERBB3B,HTR2B,CHRM5B,PRKACBB,CAMK2G1,CALM3,GNA11A,LHCGR,PRKACBA
    Metabolic pathways AHCY,CYP3A7-CYP3AP1,DHRS4L2,CHIA.3,MTHFD2L,PFKMB,POLR3D,NANP,GPT2,HADHAB
    Phosphatidylinositol signaling system PIK3CA,CALM3B,CDS1,MTMR2,CALM3,CALM3A,PIK3R2,PIP5K1BA,INPP5E,PLCD1A
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis ITPKB
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) ITPK1,ITPKB
    Synthesis of IP3 and IP4 in the cytosol ITPKB,PLCD3
    Metabolism MED21,PAICS,PHOSPHO1,B3GNT3,COX14,CYP2S1,SPTLC1,ACSF3,AS3MT,AMDHD1

    Protein Function

    ITPKA has several biochemical functions, for example, ATP binding,Rac GTPase binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKA itself. We selected most functions ITPKA had, and list some proteins which have the same functions with ITPKA. You can find most of the proteins on our site.

    Function Related Protein
    Rac GTPase binding EPS8,NOXA1,CORO1C,RAB7,DOCK4,ARHGEF2,DOCK7,FLNA,NCF2,FMNL1
    calmodulin binding TRPV5,OBSCN,MAP6,KCNN2,CAMK4,PATE4,RGS4,SPTBN1,RYR2,NOS2
    calmodulin-dependent protein kinase activity SLC14A2,CAMK2A,NETO2,MAPKAPK5,CAMK1GB,MAPKAPK2,DAPK2A,MYLK3,CAMK1,CAMK2D
    ATP binding MYH10,NMRK1,RAD17,MYO5C,SLKA,GK2,NMRK2,PRKCQ,RRM1,NUAK1
    inositol-1,4,5-trisphosphate 3-kinase activity IP6K2,IP6K1,IP6K3,ITPKC,IPMKB,ITPKB,IPMK

    Interacting Protein

    ITPKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKA here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKA.

    DBN1

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