ITPR1

  • Official Full Name

    Itpr1 inositol 1,4,5-trisphosphate receptor 1
  • Synonyms

    ITPR1;inositol 1,4,5-trisphosphate receptor 1;inositol 1,4,5-trisphosphate receptor type 1;IP3R 1;insP3R1;IP3 receptor;opisthotonus;InsP3R type I;protein PCD-6;InsP>3<R type I;type 1 InsP3 receptor;Purkinje cell protein 1;inositol 1,4,5-triphosphate receptor 1;type 1 inositol 1,4,5-trisphosphate receptor;inositol 1,4,5-trisphosphate-binding protein P400;opt;Ip3r;P400;Pcp1;IP3R1;Pcp-1;D6Pas2;InsP3R;Itpr-1;Gm10429;ENSMUSG00000072853
Cat.# Product name Source (Host) Species Tag Protein Length Price
ITPR1-4075C Recombinant Chicken ITPR1 Mammalian Cells Chicken His
ITPR1-8389M Recombinant Mouse ITPR1 Protein Mammalian Cells Mouse His
ITPR1-2346H Recombinant Human ITPR1 Protein, His-tagged E.coli Human His Gly112-Val287
ITPR1-4655M Recombinant Mouse ITPR1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ITPR1-4655M-B Recombinant Mouse ITPR1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ITPR1-4945H Recombinant Human ITPR1 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    ITPR1 involved in several pathways and played different roles in them. We selected most pathways ITPR1 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone synthesis PLCB2,Adcy4,ATF4,HSPA5,PLCB1,GPX6,CREB3L3,GPX8,ATP1B2,GNAS
    Glutamatergic synapse SHANK1,GRIA4,GRIN1,GNB2,GRIN2D,GRM4,GNB1,PPP3R1,PLD1,GRIN3A
    Estrogen signaling pathway CALML3,GNAI1,MMP9,NOS3,CREB3L3,GNAO1,CALM4,Adcy4,PIK3R2,FOS
    Alzheimers disease AKR1C1,ATP5G3,NDUFB5,COX7B2,NDUFC2-KCTD14,NDUFV2,IL1B,ATP5C1,CALM3,CAPN1
    Phosphatidylinositol signaling system PLCD1B,INPP4B,PIP4K2B,MTM1,PIP5K1A,CALM3B,CALM1A,PPIP5K1,MTMR7B,PLCD1
    Oxytocin signaling pathway RYR3,ITPR3,PRKAG3,PLCB2,PPP1CC,SRC,ROCK1,PPP3CA,PPP3R2,MAPK3
    Salivary secretion BST1,PRKG1,RYR3,GUCY1A3,CST2,PRKACA,ATP2B4,PLCB2,FXYD2,CAMP
    Circadian entrainment RYR2,PER1,GNG12,PRKCA,PLCB2,KCNJ3,GRIA4,GRIA3,PER2,GNG13
    Oocyte meiosis SMC1A,RPS6KA3A,CAMK2D1,CPEB2,PPP3R2,PPP1CAA,PTTG1,YWHABL,SMC1AL,CUL1A

    Protein Function

    ITPR1 has several biochemical functions, for example, calcium channel activity,calcium channel inhibitor activity,inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR1 itself. We selected most functions ITPR1 had, and list some proteins which have the same functions with ITPR1. You can find most of the proteins on our site.

    Function Related Protein
    protein C-terminus binding ITGB3BP,KCNIP3,TAE1,DLG1,MKI67,KSR1,SIRT1,CACNA1B,CD2AP,YWHAQ
    calcium channel activity PKD2L2,ORAI1B,TRPC2B,TRPC1,GRIN3A,GRIN2B,GPM6A,TRPC7A,PDE2A,SLC24A4
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ITPR2,AKR1C1,ITPR3
    intracellular ligand-gated calcium channel activity AKR1C1,RYR2,ITPR3,TRPA1
    protein binding MAPK11,ADORA2A,TAB1,MAGEA11,SEPT3,PDIK1L,PRKRIR,PSMC2,MRPL53,CXXC11
    protein phosphatase binding DRD1,CDKN1B,VRK3,DLG4,LCK,SHOC2,HSP90B1,KAT2A,PARD3,MAP3K5
    protein complex binding ATF1,GRIN2A,ANKRD54,SKAP1,RPTOR,CAV3,ITGB1BP1,RNF40,WASF2,RARB
    phosphatidylinositol binding ARHGAP33,SEPT12,SNX15,SNX10B,SNX31,PLD2,HIP1,ITPR3,SGK3,SNX18B
    ion channel activity CLCN3,TRPM4A,P2RX3B,KCNC2,KCNH6A,TRPC5A,GRIA3A,SCN4AA,DDX1,SCN8AB

    Interacting Protein

    ITPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR1.

    Erp44;Hspa9;Htt;Vdac1;Aco2;Ppif;Hap1;Hap1;PRKACB;HTT;CALM1;Ywhae;Ywhaz

    Resources

    References

    • Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
    • Sarachana, T; Hu, VW; et al. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. MOLECULAR AUTISM 4:-(2013).

    Ask a Question for All ITPR1 Products

    Required fields are marked with *

    My Review for All ITPR1 Products

    Required fields are marked with *