ITPR1

  • Official Full Name

    Itpr1 inositol 1,4,5-trisphosphate receptor 1
  • Synonyms

    ITPR1;inositol 1,4,5-trisphosphate receptor 1;inositol 1,4,5-trisphosphate receptor type 1;IP3R 1;insP3R1;IP3 receptor;opisthotonus;InsP3R type I;protein PCD-6;InsP>3<R type I;type 1 InsP3 receptor;Purkinje cell protein 1;inositol 1,4,5-triphosphate receptor 1;type 1 inositol 1,4,5-trisphosphate receptor;inositol 1,4,5-trisphosphate-binding protein P400;opt;Ip3r;P400;Pcp1;IP3R1;Pcp-1;D6Pas2;InsP3R;Itpr-1;Gm10429;ENSMUSG00000072853
Cat.# Product name Source (Host) Species Tag Protein Length Price
ITPR1-4075C Recombinant Chicken ITPR1 Mammalian Cells Chicken His
ITPR1-8389M Recombinant Mouse ITPR1 Protein Mammalian Cells Mouse His
ITPR1-2346H Recombinant Human ITPR1 Protein, His-tagged E.coli Human His Gly112-Val287
ITPR1-4655M Recombinant Mouse ITPR1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ITPR1-4655M-B Recombinant Mouse ITPR1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ITPR1-4945H Recombinant Human ITPR1 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    ITPR1 involved in several pathways and played different roles in them. We selected most pathways ITPR1 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cholinergic synapse GNGT1,FOS,CREB5,CHRNA7,AKT2,KCNJ4,GNG12,CHRM1,GNG7,HRAS
    Platelet activation GNAI3,APBB1IP,PTGIR,VAMP8,TBXA2R,PRKACA,PRKACB,LYN,BTK,F2RL3
    Oocyte meiosis PPP3CB,FBXO5,ADCY1B,MAD2L1,CPEB4,CALM3B,SMC1A,BTRC,PRKACA,CALM2A
    GnRH signaling pathway GRB2,CACNA1C,CALM4,HRAS,GRB2B,PRKACBB,KRAS,GNRH2,PLA2G4F,GNA11A
    Gastric acid secretion GNAI1,MYLK2,GAST,CAMK2G,SLC26A7,SLC9A4,Adcy4,CALM1,CAMK2A,PLCB4
    Retrograde endocannabinoid signaling GNGT2,GABRE,GABRA3,SLC17A6,PTGS2,PLCB3,PRKACG,GNG7,GNB1,GNG4
    Calcium signaling pathway PLCG1,CYSLTR1,CACNA1SB,SLC25A6,CAMK2G1,CHRM1,PRKCG,CALM2B,P2RX3B,HTR2C
    Glutamatergic synapse PRKCA,GRIK1,PLA2G4F,GNAQ,PLA2G4D,GNG8,GNAI2,PLD1,PLA2G4C,DLGAP1
    Pancreatic secretion RAP1A,PLA2G10,ATP1A1,CCKAR,SLC4A4,FXYD2,CPA3,CPB1,CELA3A,PLA2G1B

    Protein Function

    ITPR1 has several biochemical functions, for example, calcium channel activity,calcium channel inhibitor activity,inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR1 itself. We selected most functions ITPR1 had, and list some proteins which have the same functions with ITPR1. You can find most of the proteins on our site.

    Function Related Protein
    inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity AKR1C1,ITPR3,ITPR2
    protein binding PIP5K1A,C6,EIF4EBP1,TRMT112,CREB1,RAVER2,PFDN2,WWTR1,LGI1,FOXK1
    intracellular ligand-gated calcium channel activity RYR2,ITPR3,AKR1C1,TRPA1
    protein complex binding ANKRD32,UQCRC2,PTK2B,UGT1A6B,LCK,TELO2,FADD,GIT1,MAPK8IP2,CCNE1
    calcium channel activity CUL5,RYR1,GRIN2A,TPCN1,CACNG8A,CHRNA10,TRPC4A,RYR1B,PDE2A,SLC24A1
    protein C-terminus binding C11orf60,KCNK3,DLG4,CTGF,CD2AP,PHB2,VTA1,MLLT4,ATP1B1,DLG3
    phosphatidylinositol binding SNX1A,NOXO1,SNX27A,SNX10A,ARHGAP32,SNX27B,TULP3,SNX33,SNX9B,PASK
    protein phosphatase binding PARD3,EGFR,JAK3,DLG4,PPP1R3G,TP53,DLG3,PIK3R1,SNX3,RPA2
    ion channel activity TRPA1A,AKR1C1,TRPC2,CLCN4-2,GRIA2A,GRIK3,KCNC2,CHRNB1L,SCN11A,TRPC7A

    Interacting Protein

    ITPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR1.

    Erp44;Hspa9;Htt;Vdac1;Aco2;Ppif;Hap1;Hap1;PRKACB;HTT;CALM1;Ywhae;Ywhaz

    Resources

    References

    • Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
    • Sarachana, T; Hu, VW; et al. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. MOLECULAR AUTISM 4:-(2013).

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