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JMJD6

  • Official Full Name

    jumonji domain containing 6

  • Overview

    This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    JMJD6; jumonji domain containing 6; PSR; PTDSR; PTDSR1; bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; lysyl-hydroxylase JMJD6; phosphatidylserine receptor; jmjC domain-containing protein 6; histone arginine demethylase JMJD6; peptide-lysine 5-dioxygenase JMJD6; jumonji domain-containing protein 6;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JMJD6-301HFL Active Recombinant Full Length Human JMJD6 Protein, C-Flag-tagged Mammalian cells Flag
Human JMJD6-1968H Recombinant Human JMJD6 protein, His & T7-tagged E.coli His/T7 Met1~Glu334
Human JMJD6-207H Recombinant Human JMJD6 Protein, His-tagged E.coli His
Human JMJD6-5101HCL Recombinant Human JMJD6 293 Cell Lysate HEK293 N/A
Human JMJD6-2856H Recombinant Human JMJD6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human JMJD6-003H Recombinant Human JMJD6 Protein, GST-tagged E.coli GST 2-403
Human JMJD6-109H Recombinant Human JMJD6 Protein, GST-tagged E. coli GST 2-403
Human JMJD6-1229H-B Recombinant Human JMJD6 Protein Pre-coupled Magnetic Beads HEK293
Human JMJD6-4745H Recombinant Human JMJD6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human JMJD6-1229H Recombinant Human JMJD6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse JMJD6-8424M Recombinant Mouse JMJD6 Protein Mammalian Cell His
Mouse JMJD6-4680M-B Recombinant Mouse JMJD6 Protein Pre-coupled Magnetic Beads HEK293
Mouse JMJD6-4680M Recombinant Mouse JMJD6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Jmjd6-349M Recombinant Mouse Jmjd6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat JMJD6-3140R Recombinant Rat JMJD6 Protein Mammalian Cell His
Rat JMJD6-2796R-B Recombinant Rat JMJD6 Protein Pre-coupled Magnetic Beads HEK293
Rat JMJD6-2796R Recombinant Rat JMJD6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish JMJD6-9483Z Recombinant Zebrafish JMJD6 Mammalian Cell His
Chicken JMJD6-2406C Recombinant Chicken JMJD6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • JMJD6 Related Articles

JMJD6 involved in several pathways and played different roles in them. We selected most pathways JMJD6 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with JMJD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesEP400;ARID1A;CHD4;SAP130;SUZ12A;MSL2A;PADI2;AEBP2;SMARCA4
Chromatin organizationRUVBL2;COPRS;SETD3;ARID1A;KDM1A;PADI4;PHF20B;TADA2A;MSL2B
HDMs demethylate histonesKDM5BA;KDM5D;KDM6B;PHF8;KDM7AB;ARID5B;KDM4A;KDM5BB;KDM2B

JMJD6 has several biochemical functions, for example, RNA binding, histone demethylase activity (H3-R2 specific), histone demethylase activity (H4-R3 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by JMJD6 itself. We selected most functions JMJD6 had, and list some proteins which have the same functions with JMJD6. You can find most of the proteins on our site.

Function Related Protein
RNA bindingEIF5A;PDCD4;CPSF3;GRB7;KHDC1B;IMPDH2;GTF3A;TRNAU1APB;CELF6
histone demethylase activity (H3-R2 specific)
histone demethylase activity (H4-R3 specific)
identical protein bindingACY3;C14orf166;USP2;LCK;FKBP8;SCAND1;DHX8;ALAD;ITGB3
iron ion bindingAOX3;CYP21A2;ALKBH8;CYP19A1B;CYP2AD6;CYP3A25;Agmo;XDH;HBM
peptidyl-lysine 5-dioxygenase activity
protein bindingGOLSYN;SERPINE2;RCOR1;SYNJ2;MID1IP1;GFM2;LCE3E;TRIM28;SYT11
receptor activityP2RY11;Siglece;P2RY2;P2RY1;NLGN2A;GRIA4B;NPC1;DERL1;CLEC4M
single-stranded RNA bindingDDX58;EIF2C3;AGO2;SNRPC;AGO1;CBX7;POLR2GL;LSM14A;TLR7

JMJD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JMJD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of JMJD6.

BRD4; FRMD6; NAA50; CDK9

Neumann, B; Coakley, S; et al. EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway. NATURE 517:219-U259(2015).
Yang, HW; Chen, YZ; et al. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. NATURE COMMUNICATIONS 6:-(2015).
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