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Official Full Name jumonji domain containing 6
Background This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms JMJD6; jumonji domain containing 6; PSR; PTDSR; PTDSR1; bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; lysyl-hydroxylase JMJD6; phosphatidylserine receptor; jmjC domain-containing protein 6; histone arginine demethylase JMJD6; peptide-lysine 5-dioxygenase JMJD6; jumonji domain-containing protein 6;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human JMJD6-109H Recombinant Human JMJD6 Protein, GST-tagged E. coli GST
    Human JMJD6-003H Recombinant Human JMJD6 Protein, GST-tagged E.coli GST
    Human JMJD6-1968H Recombinant Human JMJD6 protein, His & T7-tagged E.coli His/T7
    Human JMJD6-207H Recombinant Human JMJD6 Protein, His-tagged E.coli His
    Human JMJD6-2856H Recombinant Human JMJD6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human JMJD6-4745H Recombinant Human JMJD6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human JMJD6-5101HCL Recombinant Human JMJD6 293 Cell Lysate HEK293 N/A
    Mouse Jmjd6-349M Recombinant Mouse Jmjd6 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse JMJD6-8424M Recombinant Mouse JMJD6 Protein Mammalian Cell His
    Rat JMJD6-3140R Recombinant Rat JMJD6 Protein Mammalian Cell His
    Chicken JMJD6-2406C Recombinant Chicken JMJD6 Mammalian Cell His
    Zebrafish JMJD6-9483Z Recombinant Zebrafish JMJD6 Mammalian Cell His

    jmjd6 involved in several pathways and played different roles in them. We selected most pathways jmjd6 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with jmjd6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes TAF6L; SUDS3; EPC1; SUZ12B; KDM7AB; DPY30; EED; SAP30; MORF4L1; ING5A
    Chromatin organization SMYD2; EHMT2; KDM6B; MBD3B; KDM5BB; ATXN7; DNMT3A; EPC1; GATAD2AB; RUVBL2
    HDMs demethylate histones KDM5B; KDM4A; KDM5C; ARID5B; KDM5BA; KDM1B; PHF8; KDM5D; KDM4C; KDM7AB

    jmjd6 has several biochemical functions, for example, RNA binding, histone demethylase activity (H3-R2 specific), histone demethylase activity (H4-R3 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by jmjd6 itself. We selected most functions jmjd6 had, and list some proteins which have the same functions with jmjd6. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding RNASEL3; WT1; ZNF385D; CWC15; SRSF9; ELAVL4; U2AF2A; RBM4.1; HNRNPD; CSTF1
    histone demethylase activity (H3-R2 specific) JMJD6
    histone demethylase activity (H4-R3 specific) JMJD6
    identical protein binding SNRNP200; CLDN10; APP; RASSF1; SH3BP4; VCP; AGXT2; USP4; CAD; SH3GLB1
    iron ion binding CYP2X8; P4HA2; HBD; NOS1; HBBE2; CYP2Y3; NOS2; CYP2C8; AOX3; FTH1
    peptidyl-lysine 5-dioxygenase activity JMJD6
    protein binding PPIL2; UCKL1; SLAMF6; TMEM88; KIAA0947; TULP3; CTSZ; IRF4; GNB2; B2M
    receptor activity TREML2; VMN1R44; JMJD6; NOTCH2; P2RY2; VMN1R43; CNTNAP1; NLGN2; ICAM1; ANTXR2A
    single-stranded RNA binding A1CF; DDX58; LUZP4; IFIH1; IFIT5; EIF2C3; CBX6; TLR7; AGO2; CBX8

    jmjd6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with jmjd6 here. Most of them are supplied by our site. Hope this information will be useful for your research of jmjd6.

    BRD4; FRMD6; NAA50; CDK9

    Neumann, B; Coakley, S; et al. EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway. NATURE 517:219-U259(2015).
    Yang, HW; Chen, YZ; et al. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. NATURE COMMUNICATIONS 6:-(2015).

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