JUNB
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Official Full Name
jun B proto-oncogene -
Overview
The JunB transcrIPPtion factor, also known as JunB proto-oncogene, JunB oncogene, transcrIPPtion factor JunB, and transforming protein JunB, is a basic region leucine zIPPer DNA-binding protein, and a member of the Jun family of proteins, which also inclu -
Synonyms
JUNB;jun B proto-oncogene;transcription factor jun-B;activator protein 1;AP-1
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
JUNB involved in several pathways and played different roles in them. We selected most pathways JUNB participated on our site, such as ATF-2 transcription factor network,Calcineurin-regulated NFAT-dependent transcription in lymphocytes,Calcium signaling in the CD4+ TCR pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with JUNB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Generic Transcription Pathway | NR2E3,ZNF705A,ZNF436,ZNF184,NRBF2,RNF111,ZNF557,NR2F1A,ZNF577,ESRRG |
| IL6-mediated signaling events | CRP,PIAS3,LMO4 |
| Calcium signaling in the CD4+ TCR pathway | RCAN2,BATF3,CHP,RCAN1,POU2F1,CSF2,FKBP1A,AKAP5 |
| Gene Expression | ZFP30,NR6A1A,GTF3A,NR5A1,ZBTB8OS,ZNF549,TAF1L,RARAA,MADD,HNRNPL |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | EGR2,CTLA4,EGR1,IRF4,IKZF1,CDK4,EGR4,CSF2,POU2F1,BATF3 |
| Downstream signaling in naive CD8+ T cells | EGR1,EOMES,EGR4 |
| Corticotropin-releasing hormone | PARP1,TFAP2A,TBX19,KRT14,CRHBP,ECE1,TRIM28,JUND,CRHR1,CYP11A1 |
| ATF-2 transcription factor network | JUND,MAPK14,GADD45A,RUVBL2,KCNA3,JDP2,HRK,DUSP1,KAT5,JUN |
Protein Function
JUNB has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JUNB itself. We selected most functions JUNB had, and list some proteins which have the same functions with JUNB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXI3A,FOXA,AHR2,ELF2A,OVOL2,TWIST1,TFDP1,RUNX2A,TFDP3,FOXG1D |
| transcription coactivator activity | MED13,SCAND1,NR1I3,NFKBIB,GTF2F1,GRIP1,PQBP1,PIAS2,DYRK1B,CITED2 |
| protein binding | FAM104A,JDP2,CALCA,C19orf57,SERPINB1A,RASSF7,RBBP6,TMEM218,STAMBP,DUT |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | HLTF,SRF,TCF12,ZFP750,CREB3L2,RAX,NR1H2,FOXA1,TTC6,E2F4 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NEUROD1,HOXA10,PAX5,HIST2H3A,KLF13,PITX1,HNRNPK,JDP2,RFX1A,FOSL1A |
| transcription factor binding | AHR,NEUROD1,ATG7,HAND1,RPS3,DNAJA3,LMO4,H2-AB1,NLK,TP73 |
| transcription corepressor activity | PROX1,E4F1,NEUROD2,MXD1,HAND1,PIAS1,TOB1,MAP3K10,HDAC4,SSX2 |
| DNA binding | PAX2A,RDM1,LBX1A,TET2,MAFGA,CRY2,IRX5A,RABGEF1L,VPS72,ZNF705B |
Interacting Protein
JUNB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JUNB here. Most of them are supplied by our site. Hope this information will be useful for your research of JUNB.
FOS;BATF;FOS;ATF2;FOSL2
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References
- Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
- Perdomo, MF; Hosia, W; et al. Human serum protein enhances HIV-1 replication and up-regulates the transcription factor AP-1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109:17639-17644(2012).
