KCNH2

  • Official Full Name

    Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2

  • Overview

    This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

  • Synonyms

    KCNH2;potassium voltage-gated channel, subfamily H (eag-related), member 2;ERG1;HERG;LQT2;SQT1;HERG1;Kv11.1;potassium voltage-gated channel subfamily H member 2;ERG-1;H-ERG;hERG-1;eag homolog;eag-related protein 1;ether-a-go-go-related protein 1;ether-a-go-go-related gene potassium channel 1;voltage-gated potassium channel subunit Kv11.1;ether-a-go-go-related potassium channel protein

Recombinant Proteins

  • Rat
  • Human
  • Guinea pig
  • Sus scrofa (Pig)
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • EGFP
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
KCNH2-3183R Recombinant Rat KCNH2 Protein Mammalian Cells Rat His
KCNH2-5059HCL Recombinant Human KCNH2 293 Cell Lysate HEK293 Human Non
KCNH2-0838H Recombinant Human KCNH2 Protein (M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005), eGFP tagged Mammalian Cells Human EGFP M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005
KCNH2-15H Recombinant Human KCNH2-3C-eGFP Protein (M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005), C-10×His-tagged Mammalian Cells Human His M1-S1159 end, S631A, ΔP141-L380 and ΔS871-R1005
KCNH2-2839R Recombinant Rat KCNH2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
KCNH2-2839R-B Recombinant Rat KCNH2 Protein Pre-coupled Magnetic Beads HEK293 Rat
RFL1218CF Recombinant Full Length Guinea Pig Potassium Voltage-Gated Channel Subfamily H Member 2(Kcnh2) Protein, His-Tagged E.coli Guinea pig His Full L. Full Length (1-162)
RFL20356SF Recombinant Full Length Pig Potassium Voltage-Gated Channel Subfamily H Member 2(Kcnh2) Protein, His-Tagged E.coli Sus scrofa (Pig) His Full L. Full Length (1-97)

    Involved Pathway

    KCNH2 involved in several pathways and played different roles in them. We selected most pathways KCNH2 participated on our site, such as Neuronal System,Potassium Channels,SIDS Susceptibility Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Voltage gated Potassium channels KCNS2,KCNC1,KCNQ2A,KCNA1,KCNH1B,KCNV1,KCNAB1A,KCNC2,KCNAB2,KCNA6
    Neuronal System SLC1A7B,KCNH6,KCND1,KCNAB1A,GNGT2B,KCNN1A,KCNJ1A.4,KCNF1A,GJA10,CACNG2B
    Potassium Channels KCNH8,KCNN1A,DDX1,KCNK13B,KCNH6A,KCNH5,KCNK4,KCNMB2,KCNS3A,KCNA2B
    SIDS Susceptibility Pathways POU2F2,DEAF1,TPPP,KCNQ1,CREM,SCN3B,YBX1,IL1RN,TAC1,PHOX2B

    Protein Function

    KCNH2 has several biochemical functions, for example, C3HC4-type RING finger domain binding,delayed rectifier potassium channel activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH2 itself. We selected most functions KCNH2 had, and list some proteins which have the same functions with KCNH2. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin protein ligase binding GPR19,RPA2,DTX1,SCAMP3,MUL1,PRKAR2B,PER1,ANKRD32,HDAC6,XRCC5
    delayed rectifier potassium channel activity KCNH1,KCNC1B,KCNA5,KCNV2B,KCNQ1,KCNA10,KCNS3A,KCNB1,KCNQ2A,KCNV2
    C3HC4-type RING finger domain binding DNAJA1,HSPA1B,HSPA1A,PINK1,HSPA8
    identical protein binding PSMD4,TRIM23,PHC2,TRA@,P2RX2,GRIK5,DLC,HOOK1,AHCY,SDK2
    voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization KCNE2,KCNQ1
    inward rectifier potassium channel activity KCNJ4,KCNJ12,KCNJ1A.2,KCNK6,KCNJ14,KCNJ15,KCNJ1,KCNJ1A.5,KCNJ1A.3,KCNJ16
    protein homodimerization activity AOC3,TIGIT,DAPK3,CISD2,S100A11,CD226,SLC14A2,NETO2,TMEM173,PARK7
    contributes_to voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization KCNE1,KCNE1L
    phosphorelay sensor kinase activity KCNH5,KCNH1B,KCNH8,CASS4,KCNH1,KCNH1A,KCNH5A

    Interacting Protein

    KCNH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH2.

    CAV1;PASK;NDUFS6;ARHH;CDC73;GABARAP;MAP1LC3B

    Resources

    References

    • Kinoshita, K; Yamaguchi, Y; et al. A Novel Missense Mutation Causing a G487R Substitution in the S2-S3 Loop of Human ether-a-go-go-Related Gene Channel. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 23:1246-1253(2012).
    • Wulff, H; Castle, NA; et al. Voltage-gated potassium channels as therapeutic targets. NATURE REVIEWS DRUG DISCOVERY 8:982-1001(2009).

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