KCNK3

  • Official Full Name

    potassium channel, subfamily K, member 3
  • Overview

    This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
  • Synonyms

    KCNK3;potassium channel, subfamily K, member 3;potassium channel subfamily K member 3;K2p3.1;TASK;TASK 1;cardiac potassium channel;two pore K(+) channel KT3.1;two P domain potassium channel;two pore potassium channel KT3.1;TWIK-related acid-sens

Recombinant Proteins

  • Rat
  • Mouse
  • Human
  • Mus musculus
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Myc
  • Avi
  • Fc

    Involved Pathway

    KCNK3 involved in several pathways and played different roles in them. We selected most pathways KCNK3 participated on our site, such as Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aldosterone synthesis and secretion ATF2,ADCY8,HSD3B5,AGTR1A,PRKACB,ATF4,NR4A2,LDLR,CREB3L4,PDE2A

    Protein Function

    KCNK3 has several biochemical functions, for example, S100 protein binding,ion channel activity,open rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK3 itself. We selected most functions KCNK3 had, and list some proteins which have the same functions with KCNK3. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity DR1,HIST1H4F,UNC13A,ATF3,VEGFA,H2AFZ,HIST1H2B8,HIST1H3D,FLOT2,HIST4H4
    potassium channel activity KCNK10,KCNS3A,KCNK4,KCNA1,KCNJ11L,KCNV2B,KCNC3A,KCNK2B,KCNC4,KCNIP4
    protein C-terminus binding YEATS4,XRCC5,ECM1,ATP2A2,RBFOX1,KCNIP3,NEIL1,HESX1,PHB,DST
    S100 protein binding AGER,FGF1,ANXA2,S100B,AHNAK,EZR,S100A6,S100A11,S100A1,DDX1
    open rectifier potassium channel activity DDX1,KCNK3A
    ion channel activity CNGA5,TRPC4A,GRIK5,CLCNKB,KCNC3A,GRIN1A,TRPC6A,RYR1B,CATSPER2,CLCN3
    protein homodimerization activity SLK,INHBB,ZHX3,EXT1,TCF4,PLD6,DMRT3,EFR3A,LDB1,BNIP3
    potassium ion leak channel activity KCNK13B,KCNK3A,KCNK9,KCNK1,DDX1,TMEM175,KCNK6,KCNK5B,KCNK1B,KCNK1A

    Interacting Protein

    KCNK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK3.

    Resources

    References

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