KCNK3
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Official Full Name
potassium channel, subfamily K, member 3 -
Overview
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. -
Synonyms
KCNK3;potassium channel, subfamily K, member 3;potassium channel subfamily K member 3;K2p3.1;TASK;TASK 1;cardiac potassium channel;two pore K(+) channel KT3.1;two P domain potassium channel;two pore potassium channel KT3.1;TWIK-related acid-sens
Recombinant Proteins
- Rat
- Mouse
- Human
- Mus musculus
- Mammalian Cells
- E.coli
- HEK293
- His
- Myc
- Avi
- Fc
Involved Pathway
KCNK3 involved in several pathways and played different roles in them. We selected most pathways KCNK3 participated on our site, such as Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone synthesis and secretion | AGTR1,PLCB1,CAMK2D,PDE2A,PRKCE,ADCY9,CALM2,CREB3L2,NR4A2,CREB5 |
Protein Function
KCNK3 has several biochemical functions, for example, S100 protein binding,ion channel activity,open rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK3 itself. We selected most functions KCNK3 had, and list some proteins which have the same functions with KCNK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S100 protein binding | S100A6,FGF1A,AHNAK,AGER,EZR,S100B,ANXA2,FGF1,S100A11,S100A1 |
| protein homodimerization activity | BARD1,NR2F2,RPE,NTSR1,RCHY1,NACC2,ACAT1,NAMPT,VPS24,AMICA1 |
| protein C-terminus binding | SIAH1,NEFL,CDC37,XRCC6,SAE1,PEX5,CORO1A,PDZD3,MID1IP1,ATP1B1 |
| protein heterodimerization activity | OSTA,DMRT3,GTF2A2,PML,HIST1H2B5,TOP2B,HIST1H2BF,HIST2H2AA4,SYCP3,GRIN1 |
| ion channel activity | KCNH5A,TRPC4A,P2RX4B,RYR1B,SCN11A,TRPC6A,CACNA1SA,GRIK3,CLCNK,TRPM5 |
| potassium ion leak channel activity | KCNK4,KCNK7,KCNK13B,KCNK3A,KCNK10B,KCNK10,DDX1,KCNK9,KCNK15,KCNK5B |
| potassium channel activity | KCNQ2,KCNC4,KCNK16,KCNK13B,KCNIP3,KCNIP4,ABCC9,KCNK9,KCNK5A,KCNK7 |
| open rectifier potassium channel activity | DDX1,KCNK3A |
Interacting Protein
KCNK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK3.
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