KDM6B
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Official Full Name
lysine (K)-specific demethylase 6B -
Overview
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. -
Synonyms
KDM6B;lysine (K)-specific demethylase 6B;JMJD3;lysine-specific demethylase 6B;lysine demethylase 6B;jmjC domain-containing protein 3;jumonji domain-containing protein 3;jumonji domain containing 3, histone lysine demethylase
Recombinant Proteins
- Human
- Mouse
- Insect Cells
- Mammalian Cells
- HEK293
- E.coli
- Flag
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KDM6B-562H |
Active Recombinant Human KDM6B, Flag-tagged
|
Insect Cells | Human | Flag | 1043-end a.a. |
|
| KDM6B-1066H | Recombinant Human KDM6B | Mammalian Cells | Human | His |
|
|
| KDM6B-8599M | Recombinant Mouse KDM6B Protein | Mammalian Cells | Mouse | His |
|
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| KDM6B-0525H | Recombinant Human KDM6B Protein (D1141-L1636), Tag Free | Insect Cells | Human | Non | D1141-L1636 |
|
| KDM6B-0526H | Recombinant Human KDM6B Protein (D1141-L1636), His tagged | Insect Cells | Human | His | D1141-L1636 |
|
| KDM6B-3201H | Recombinant Human KDM6B Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
|
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| KDM6B-3201H-B | Recombinant Human KDM6B Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| KDM6B-4786M | Recombinant Mouse KDM6B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
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| KDM6B-4786M-B | Recombinant Mouse KDM6B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
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| KDM6B-5162H | Recombinant Human KDM6B protein(1176-1505aa), His-tagged | E.coli | Human | His | 1176-1505aa |
|
Involved Pathway
KDM6B involved in several pathways and played different roles in them. We selected most pathways KDM6B participated on our site, such as Cellular Senescence,Cellular responses to stress,Chromatin modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative Stress Induced Senescence | EED,SUZ12,BMI1A,RING1,BMI1B,RNF2,CBX4,CBX8,PHC2,PHC3 |
| Chromatin modifying enzymes | KDM1A,SAP30,MBIP,EPC1,ING4,DMAP1,BRPF3,SMYD3,AEBP2,ELP2 |
| HDMs demethylate histones | KDM5A,PHF2,KDM4A,KDM2A,PHF8,JMJD6,KDM5C,ARID5B,KDM1A,KDM4D |
| Chromatin organization | ACTL6B,CSRP2BP,SMYD3,MBD3A,ING5A,PADI4,SMYD2A,KDM5C,SUZ12,MCRS1 |
| Cellular Senescence | HIST2H3C,CBX8,HIST1H1E,CBX6A,MINK1,HIST1H1A,CBX8A,CEBPB,BMI1A,MOV10 |
| Cellular responses to stress | HSPH1,TXNRD2,EGLN2,KAT5,DYNLL2,RBB4L,H3F3D,CDK6,HIST3H2BB,RNF2 |
Protein Function
KDM6B has several biochemical functions, for example, beta-catenin binding,chromatin binding,dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM6B itself. We selected most functions KDM6B had, and list some proteins which have the same functions with KDM6B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MMP15,KRTAP5-6,SERPINB8,STARD10,PSTPIP1,ZNF148,EBF1,ARID5A,KAT8,GUCY1B3 |
| sequence-specific DNA binding | EVX1,HOXD4A,MSX2,FOXI3B,SPIC,RXRAA,IKZF3,E2F5,TRP63,NFE2L2B |
| metal ion binding | ZRANB1B,PRMT3,SCNM1,AGAP2,ZNFL1,DNMT3A,PDE4C,ZNF544,PHOSPHO2,GDPD2 |
| chromatin binding | MED12,NFATC3,TPR,RAD51,AIRE,HMGB3,CIC,HOXD10,BRD2,PBX2 |
| beta-catenin binding | MED12,APC2,CDH2,ASH2L,APC,SLC9A3R2,CD2AP,GRIP1,PTPRK,SLC9A3R1 |
| histone demethylase activity (H3-K27 specific) | KDM6A,KDM6BB,JHDM1D,PHF8,KDM7AB |
| dioxygenase activity | PHYHD1,HPDA,KDM3B,HPDB,KDM5D,ADOB,ALOX5B.2,LEPREL1,ALOX5A,PTGS2 |
Interacting Protein
KDM6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM6B here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM6B.
ESR1;TK1;CSNK2B;dacA;y2781_yerpe;Cbx1
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References
- Guo, XQ; Tian, ZT; et al. Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2 alpha. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 47:106-113(2015).
- Zhang, PP; Wang, XL; et al. DNA Methylation-mediated Repression of miR-941 Enhances Lysine (K)-specific Demethylase 6B Expression in Hepatoma Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 289:24724-24735(2014).
