Recombinant Human KDM6B Protein (D1141-L1636), His tagged

• Cat.No.: KDM6B-0526H
• Product Overview: Recombinant Human 8His-TEV-KDM6B(D1141-L1636) Protein was expressed in Insect cell.

Specification

• Description: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex.
• Source: Insect cell
• Species: Human
• Tag: His
• Form: Liquid
• Protein Length: D1141-L1636
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: KDM6B lysine (K)-specific demethylase 6B [ Homo sapiens (human) ]
• Official Symbol: KDM6B
• Synonyms: KDM6B; lysine (K)-specific demethylase 6B; JMJD3, jumonji domain containing 3, jumonji domain containing 3, histone lysine demethylase; lysine-specific demethylase 6B; KIAA0346; lysine demethylase 6B; jmjC domain-containing protein 3; jumonji domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase; JMJD3
• Gene ID: 23135
• mRNA Refseq: NM_001080424
• Protein Refseq: NP_001073893
• MIM: 611577
• UniProt ID: O15054