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KISS1

  • Official Full Name

    Kiss1 KiSS-1 metastasis-suppressor

  • Overview

    KiSS-1 gene encodes metastin, also known as kisspeptin or KiSS-1 peptide, which binds to a G protein-coupled receptor GPR54. KiSS-1 is dominantly expressed in brain (e.g. anteroventral periventricular nucleus, AVPV arcuate nucleus, ARC), placenta, and pancreas, etc. Metastin plays an important role in regulating the GnRH secretion in brain and MMP-9 expression in placenta, which is associated with development of puberty and sex maturation (e.g. Idiopathic hypogonadotropic hypogonadism, IHH) as well as placentation (e.g. pre-eclampsia), respectively. Metastin was originally discovered as a tumor metastasis suppressor (e.g. melanoma, breast cancer).
  • Synonyms

    KISS1; KiSS-1 metastasis-suppressor; metastasis-suppressor KiSS-1; metastin; kisspeptin-1; 0610012C01Rik; metastatin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KISS1-28652TH Recombinant Human KISS1 E.coli N/A 119 amino acids
Human KISS1-4937HCL Recombinant Human KISS1 293 Cell Lysate HEK293 N/A
Human KISS1-3825H Recombinant Human KISS1 protein, His-tagged E.coli His 1-138 aa
Human KISS1-1646H Recombinant Human KISS1 protein, His & T7-tagged E.coli His/T7 Glu20~Gly138 (Accession # Q15726)
Human KISS1-5077H Recombinant Human KISS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human KISS1-3135H Recombinant Human KISS1 Protein (Glu20-Gly138), N-His tagged E.coli N-His Glu20-Gly138
Mouse Kiss1-7885M Recombinant Mouse Kiss1 protein, His & GST-tagged E.coli His/GST Met1~Gly126
Mouse Kiss1-3696M Recombinant Mouse Kiss1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat KISS1-3263R Recombinant Rat KISS1 Protein Mammalian Cell His
Rat KISS1-2919R-B Recombinant Rat KISS1 Protein Pre-coupled Magnetic Beads HEK293
Rat KISS1-2919R Recombinant Rat KISS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Kiss1-1070R Recombinant Rat Kiss1 Protein, His-tagged CHO N-His Glu20-Gly124
Zebrafish KISS1-6297Z Recombinant Zebrafish KISS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KISS1 Related Articles

KISS1 involved in several pathways and played different roles in them. We selected most pathways KISS1 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with KISS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)OPN4.1;CHRM1;OPN1MW;EDN1;GPR31;PENKA;NPFFR2;DRD5;LPAR1
G alpha (q) signalling eventsPROK1;GCGA;TAE1;FPR-RS3;TRIO;HCRT;PROKR1;OXTRL;FPR-RS6
GPCR downstream signalingSOUL3;CHRM3;TAS2R7;AMCF-II;GRP;CALCA;ITSN1;GPR4;GPR132
GPCR ligand bindingTAC3;ADCYAP1;RLN3;DRD4;OPN4A;EMR2;GPR120;PPY;QRFP
Gastrin-CREB signalling pathway via PKC and MAPKGPR132;PROKR2;TRPC7;RGS18;LPAR1;MLN;DGKB;LPAR2B;MGLL
Peptide ligand-binding receptorsPPY;AMCF-II;NMB;CCRL2;PYY;EDN3;KISS1;EDNRAB;SST1.1
Signal TransductionARHGAP17B;RSPO1;LPAR2A;GPR18;IFT52;APOC2;TJP2B;RHOF;AES
Signaling by GPCRRGS10;HCAR1-2;PLEKHG2;SST1.1;OXGR1A.2;FGD4;PTH;OXGR1;TAS2R3

KISS1 has several biochemical functions, for example, kisspeptin receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KISS1 itself. We selected most functions KISS1 had, and list some proteins which have the same functions with KISS1. You can find most of the proteins on our site.

Function Related Protein
kisspeptin receptor binding
protein bindingUBR1;KCNIP2;ALPP;CBX6;CLOCKA;MAPKBP1;SH3BP4;OAZ2;C4orf19

KISS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KISS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KISS1.

Han, YG; Liu, GQ; et al. KISS1 can be used as a novel target for developing a DNA immunocastration vaccine in ram lambs. VACCINE 33:777-782(2015).
Papaoiconomou, E; Lymperi, M; et al. Kiss-1/GPR54 Protein Expression in Breast Cancer. ANTICANCER RESEARCH 34:1401-1407(2014).
  • Q&As
  • Reviews

Q&As (5)

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Can KISS1 be a target for developing contraceptive methods? 12/11/2022

KISS1-based approaches are being investigated as potential targets for developing contraceptives.

How does KISS1 play a role in regulating reproduction? 06/30/2020

KISS1 regulates reproduction by stimulating the release of gonadotropin-releasing hormone (GnRH).

Are there any therapeutic applications of KISS1 in managing infertility? 11/22/2019

KISS1-based therapies are being explored for the management of infertility, especially in cases of hypothalamic dysfunction.

How does the dysregulation of KISS1 protein relate to conditions like hypogonadotropic hypogonadism? 05/21/2017

Dysregulation of KISS1 can lead to hypogonadotropic hypogonadism, a condition characterized by insufficient gonadal function.

Can KISS1 protein be used as a biomarker for conditions like precocious puberty? 01/29/2016

KISS1 protein levels can be assessed to diagnose and monitor conditions like precocious puberty.

Customer Reviews (3)

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Reviews
04/17/2019

    Whether I need assistance in experimental design, troubleshooting, or data interpretation, they provide prompt and personalized support, ensuring that my research progresses smoothly and efficiently.

    11/07/2017

      The manufacturer's commitment to customer support and collaboration greatly enhances the overall research experience.

      01/28/2017

        This proactive approach not only aids in expanding my knowledge but also encourages continuous improvement and innovation in my experimental approach.

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