KISS1
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Official Full Name
Kiss1 KiSS-1 metastasis-suppressor
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Overview
KiSS-1 gene encodes metastin, also known as kisspeptin or KiSS-1 peptide, which binds to a G protein-coupled receptor GPR54. KiSS-1 is dominantly expressed in brain (e.g. anteroventral periventricular nucleus, AVPV arcuate nucleus, ARC), placenta, and pancreas, etc. Metastin plays an important role in regulating the GnRH secretion in brain and MMP-9 expression in placenta, which is associated with development of puberty and sex maturation (e.g. Idiopathic hypogonadotropic hypogonadism, IHH) as well as placentation (e.g. pre-eclampsia), respectively. Metastin was originally discovered as a tumor metastasis suppressor (e.g. melanoma, breast cancer). -
Synonyms
KISS1; KiSS-1 metastasis-suppressor; metastasis-suppressor KiSS-1; metastin; kisspeptin-1; 0610012C01Rik; metastatin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | KISS1-28652TH | Recombinant Human KISS1 | E.coli | N/A | 119 amino acids | |
Human | KISS1-4937HCL | Recombinant Human KISS1 293 Cell Lysate | HEK293 | N/A | ||
Human | KISS1-3825H | Recombinant Human KISS1 protein, His-tagged | E.coli | His | 1-138 aa | |
Human | KISS1-1646H | Recombinant Human KISS1 protein, His & T7-tagged | E.coli | His/T7 | Glu20~Gly138 (Accession # Q15726) | |
Human | KISS1-5077H | Recombinant Human KISS1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | KISS1-3135H | Recombinant Human KISS1 Protein (Glu20-Gly138), N-His tagged | E.coli | N-His | Glu20-Gly138 | |
Mouse | Kiss1-7885M | Recombinant Mouse Kiss1 protein, His & GST-tagged | E.coli | His/GST | Met1~Gly126 | |
Mouse | Kiss1-3696M | Recombinant Mouse Kiss1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rat | KISS1-3263R | Recombinant Rat KISS1 Protein | Mammalian Cell | His | ||
Rat | KISS1-2919R-B | Recombinant Rat KISS1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | KISS1-2919R | Recombinant Rat KISS1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Kiss1-1070R | Recombinant Rat Kiss1 Protein, His-tagged | CHO | N-His | Glu20-Gly124 | |
Zebrafish | KISS1-6297Z | Recombinant Zebrafish KISS1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- KISS1 Related Articles
KISS1 involved in several pathways and played different roles in them. We selected most pathways KISS1 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with KISS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Class A/1 (Rhodopsin-like receptors) | OPN4.1;CHRM1;OPN1MW;EDN1;GPR31;PENKA;NPFFR2;DRD5;LPAR1 |
G alpha (q) signalling events | PROK1;GCGA;TAE1;FPR-RS3;TRIO;HCRT;PROKR1;OXTRL;FPR-RS6 |
GPCR downstream signaling | SOUL3;CHRM3;TAS2R7;AMCF-II;GRP;CALCA;ITSN1;GPR4;GPR132 |
GPCR ligand binding | TAC3;ADCYAP1;RLN3;DRD4;OPN4A;EMR2;GPR120;PPY;QRFP |
Gastrin-CREB signalling pathway via PKC and MAPK | GPR132;PROKR2;TRPC7;RGS18;LPAR1;MLN;DGKB;LPAR2B;MGLL |
Peptide ligand-binding receptors | PPY;AMCF-II;NMB;CCRL2;PYY;EDN3;KISS1;EDNRAB;SST1.1 |
Signal Transduction | ARHGAP17B;RSPO1;LPAR2A;GPR18;IFT52;APOC2;TJP2B;RHOF;AES |
Signaling by GPCR | RGS10;HCAR1-2;PLEKHG2;SST1.1;OXGR1A.2;FGD4;PTH;OXGR1;TAS2R3 |
KISS1 has several biochemical functions, for example, kisspeptin receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KISS1 itself. We selected most functions KISS1 had, and list some proteins which have the same functions with KISS1. You can find most of the proteins on our site.
Function | Related Protein |
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kisspeptin receptor binding | |
protein binding | UBR1;KCNIP2;ALPP;CBX6;CLOCKA;MAPKBP1;SH3BP4;OAZ2;C4orf19 |
KISS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KISS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KISS1.
- Q&As
- Reviews
Q&As (5)
Ask a questionKISS1-based approaches are being investigated as potential targets for developing contraceptives.
KISS1 regulates reproduction by stimulating the release of gonadotropin-releasing hormone (GnRH).
KISS1-based therapies are being explored for the management of infertility, especially in cases of hypothalamic dysfunction.
Dysregulation of KISS1 can lead to hypogonadotropic hypogonadism, a condition characterized by insufficient gonadal function.
KISS1 protein levels can be assessed to diagnose and monitor conditions like precocious puberty.
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