Recombinant Mouse Kiss1 Protein, Myc/DDK-tagged

• Cat.No.: Kiss1-3696M
• Product Overview: Purified recombinant protein of mouse full-length KiSS-1 metastasis-suppressor (Kiss1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 14.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Kiss1 KiSS-1 metastasis-suppressor [ Mus musculus (house mouse) ]
• Official Symbol: Kiss1
• Synonyms: KISS1; KiSS-1 metastasis-suppressor; metastasis-suppressor KiSS-1; metastin; kisspeptin-1; 0610012C01Rik; metastatin
• Gene ID: 280287
• mRNA Refseq: NM_178260
• Protein Refseq: NP_839991
• UniProt ID: Q6Y4S4