KRT1

  • Official Full Name

    keratin 1

  • Overview

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
  • Synonyms

    KRT1; keratin 1; K1; CK1; EHK; EHK1; EPPK; KRT1A; NEPPK; keratin, type II cytoskeletal 1; CK-1; cytokeratin 1; cytokeratin-1; 67 kDa cytokeratin; hair alpha protein; type-II keratin Kb1; epidermolytic hyperkeratosis 1; KRTA; Keratin-1; Keratin PAN; keratin 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|S
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KRT1-26824TH Recombinant Human KRT1 Wheat Germ N/A 110 amino acids
Human KRT1-940H Recombinant Human KRT1 protein, His-tagged E.coli His Glu487~Arg644
Human KRT1-3144H Recombinant Human KRT1 protein, His-tagged E.coli His 2-644aa
Human KRT1-4379H Recombinant Human KRT1 Protein (Glu370-Glu489), N-His tagged E.coli N-His Glu370-Glu489
Human KRT1-4876H Recombinant Human KRT1 Protein, GST-tagged Wheat Germ GST
Mouse Krt1-2701M Recombinant Mouse Krt1 protein, His-tagged E.coli His Arg189~Glu497 (Accession # P04104)
Mouse KRT1-8813M Recombinant Mouse KRT1 Protein Mammalian Cell His
Mouse KRT1-4910M Recombinant Mouse KRT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse KRT1-4910M-B Recombinant Mouse KRT1 Protein Pre-coupled Magnetic Beads HEK293
Rat Krt1-2703R Recombinant Rat Krt1 protein, His-tagged E.coli His Glu489~Asn625 (Accession # Q6IMF3)
Rat KRT1-3308R Recombinant Rat KRT1 Protein Mammalian Cell His
Rat Krt1-2702R Recombinant Rat Krt1 protein, His & S-tagged E.coli His/S Ile350~Glu488 (Accession # Q6IMF3)
Rat KRT1-2964R Recombinant Rat KRT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat KRT1-2964R-B Recombinant Rat KRT1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

KRT1 involved in several pathways and played different roles in them. We selected most pathways KRT1 participated on our site, such as Corticotropin-releasing hormone, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Corticotropin-releasing hormoneCRH;KRT14;CRHBP;JUND;CRHR2;ADRBK2;JUNB;IVL;TRIM28
Regulation of Wnt-mediated beta catenin signaling and target gene transcriptionCBY1;MYOG;KRT1;TLE4;TNIK;AES;TCF4;ZCCHC12;KCNIP4

KRT1 has several biochemical functions, for example, carbohydrate binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT1 itself. We selected most functions KRT1 had, and list some proteins which have the same functions with KRT1. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingEVA1C;Mgl2;GFPT1;SIGLEC12;GANAB;KRT1;KLRF1;LGALS1L1;LGALSL
protein bindingGAB1;TMCO6;CTAG1A;PTPN3;HIST1H4F;DHPS;IL17RA;TTC6;ITPR1
receptor activityCD4;NLGN4B;CADM1B;PVRL3B;KLRB1F;P2RY11;KLRG1;TREM2;VMN1R43
structural molecule activityCLTC;LMNB2;SPRR2H;CTNNA1;CRCT1;KRT84;OC90;KRT72-PS;MATR3

KRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT1.

VCAM1; PPP2R2B; CDH1; APC; YWHAQ; TANK; gd3; midostaurin; E2F3; GABARAP; EGFR; IGHG1; IGHM; IGHA1; APOA1

Research Area

Related articles

Nakaya, Y; Hoshino, S; et al. Mapping of a neutralizing epitope in the surface envelope protein of porcine endogenous retrovirus subgroup B. JOURNAL OF GENERAL VIROLOGY 92:940-944(2011).
Wang, WH; Song, SJ; et al. Disturbed keratin expression and distinct genotype of ichthyosis hystrix Lambert type. EUROPEAN JOURNAL OF DERMATOLOGY 20:567-572(2010).
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