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KRT1

Official Full Name

keratin 1
Overview

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Synonyms

KRT1; keratin 1; K1; CK1; EHK; EHK1; EPPK; KRT1A; NEPPK; keratin, type II cytoskeletal 1; CK-1; cytokeratin 1; cytokeratin-1; 67 kDa cytokeratin; hair alpha protein; type-II keratin Kb1; epidermolytic hyperkeratosis 1; KRTA; Keratin-1; Keratin PAN; keratin 1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KRT1-26824TH	Recombinant Human KRT1	Wheat Germ	Non	110 amino acids	Inquiry
Human	KRT1-940H	Recombinant Human KRT1 protein, His-tagged	E.coli	His	Glu487~Arg644	$298 / 10μg
Human	KRT1-3144H	Recombinant Human KRT1 protein, His-tagged	E.coli	His	2-644aa	Inquiry
Human	KRT1-4379H	Recombinant Human KRT1 Protein (Glu370-Glu489), N-His tagged	E.coli	His	Glu370-Glu489	Inquiry
Human	KRT1-4876H	Recombinant Human KRT1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	Krt1-2701M	Recombinant Mouse Krt1 protein, His-tagged	E.coli	His	Arg189~Glu497 (Accession # P04104)	Inquiry
Mouse	KRT1-8813M	Recombinant Mouse KRT1 Protein	Mammalian Cell	His		Inquiry
Mouse	KRT1-4910M	Recombinant Mouse KRT1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	KRT1-4910M-B	Recombinant Mouse KRT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Krt1-2703R	Recombinant Rat Krt1 protein, His-tagged	E.coli	His	Glu489~Asn625 (Accession # Q6IMF3)	Inquiry
Rat	KRT1-3308R	Recombinant Rat KRT1 Protein	Mammalian Cell	His		Inquiry
Rat	Krt1-2702R	Recombinant Rat Krt1 protein, His & S-tagged	E.coli	His&S	Ile350~Glu488 (Accession # Q6IMF3)	Inquiry
Rat	KRT1-2964R	Recombinant Rat KRT1 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	KRT1-2964R-B	Recombinant Rat KRT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

KRT1 involved in several pathways and played different roles in them. We selected most pathways KRT1 participated on our site, such as Corticotropin-releasing hormone, Regulation of Wnt-mediated beta catenin signaling and target gene transcription, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Corticotropin-releasing hormone	CYP11A1;CRHR1;CRHBP;ECE1;CRH;ADRBK2;TFAP2A;PARP1;JUNB
Regulation of Wnt-mediated beta catenin signaling and target gene transcription	CDX4;TLE2;T;TCF4;TLE1;CYR61;BCL9;HBP1;TNIK

KRT1 has several biochemical functions, for example, carbohydrate binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT1 itself. We selected most functions KRT1 had, and list some proteins which have the same functions with KRT1. You can find most of the proteins on our site.

Function	Related Protein
carbohydrate binding	SIGLEC10;NPTX2;POC1BL;GALM;LMAN1L;LGALS8;CD209;OLR1;GALNT1
protein binding	ABLIM3;TEKT1;CACNA1SB;OAS3;SARM1;DHPS;RABAC1;SRSF10;CEACAM6
receptor activity	OPN1SW;PVRL3;GRIA2A;IL18RAP;CRTAM;GRIA3B;NLGN3;ITGB4;VMN1R40
structural molecule activity	SNTB1;EPB41L1;CLDN22;NUMA1;NGS;TUBA1C;CLDN5A;SPRR3;CLDN10B

KRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT1.

VCAM1; PPP2R2B; CDH1; APC; YWHAQ; TANK; gd3; midostaurin; E2F3; GABARAP; EGFR; IGHG1; IGHM; IGHA1; APOA1

Research Area

Nakaya, Y; Hoshino, S; et al. Mapping of a neutralizing epitope in the surface envelope protein of porcine endogenous retrovirus subgroup B. JOURNAL OF GENERAL VIROLOGY 92:940-944(2011).

Wang, WH; Song, SJ; et al. Disturbed keratin expression and distinct genotype of ichthyosis hystrix Lambert type. EUROPEAN JOURNAL OF DERMATOLOGY 20:567-572(2010).