Recombinant Human KRT1

Cat.No. : KRT1-26824TH
Product Overview : Recombinant fragment of Human KRT1 protein with an N terminal proprietary tag; predicted mwt: 37.73 kDa inclusive of tag.
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Description : The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Protein length : 110 amino acids
Molecular Weight : 37.730kDa inclusive of tags
Source : Wheat germ
Tissue specificity : The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : HGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSI SDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQ ELMNTKLALDLEIATYRTLLEGEESRMSGE
Sequence Similarities : Belongs to the intermediate filament family.
Gene Name : KRT1 keratin 1 [ Homo sapiens ]
Official Symbol : KRT1
Synonyms : KRT1; keratin 1; EHK1, epidermolytic hyperkeratosis 1; keratin, type II cytoskeletal 1; KRT1A;
Gene ID : 3848
mRNA Refseq : NM_006121
Protein Refseq : NP_006112
MIM : 139350
Uniprot ID : P04264
Chromosome Location : 12q13.13
Pathway : Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem;
Function : protein binding; receptor activity; structural constituent of cytoskeleton; sugar binding;

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