L2HGDH

  • Official Full Name

    L-2-hydroxyglutarate dehydrogenase

  • Overview

    This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe mental retardation.
  • Synonyms

    L2HGDH; L-2-hydroxyglutarate dehydrogenase; C14orf160, chromosome 14 open reading frame 160; L-2-hydroxyglutarate dehydrogenase, mitochondrial; 2 hydroxyglutarate dehydrogenase; FLJ12618; mitochondrial; C14orf160; Duranin; L2HDH_HUMAN; OTTHUMP00000178967; OTTHUMP00000178968; OTTHUMP00000244606; alpha-ketoglutarate reductase; 2-hydroxyglutarate dehydrogenase; alpha-hydroxyglutarate oxidoreductase; L-alpha-hydroxyglutarate dehydrogenase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • Fc
  • Avi
  • SUMO
  • Myc
  • DDK
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human L2HGDH-944H Recombinant Human L2HGDH Mammalian Cell His
Human L2HGDH-372HCL Recombinant Human L2HGDH lysate HEK293 Non
Human L2HGDH-173H Recombinant Human L2HGDH Protein, MYC/DDK-tagged HEK293 Myc&DDK
Human L2HGDH-1120H Recombinant Human L2HGDH Protein (52-463 aa), His-SUMO-tagged E.coli His&SUMO 52-463 aa
Human L2HGDH-727HFL Recombinant Full Length Human L2HGDH Protein, C-Flag-tagged Mammalian cells Flag
Human L2HGDH-4798H Recombinant Human L2HGDH protein, His-SUMO-tagged E.coli His&SUMO 52-441aa
Human L2HGDH-1271H-B Recombinant Human L2HGDH Protein Pre-coupled Magnetic Beads HEK293
Human L2HGDH-1271H Recombinant Human L2HGDH Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Mouse L2hgdh-3741M Recombinant Mouse L2hgdh Protein, Myc/DDK-tagged HEK293T Myc&DDK
Bovine L2HGDH-615B Recombinant Bovine L2HGDH Protein (53-463 aa), His-SUMO-tagged E.coli His&SUMO 53-463 aa
Zebrafish L2HGDH-7342Z Recombinant Zebrafish L2HGDH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

L2HGDH involved in several pathways and played different roles in them. We selected most pathways L2HGDH participated on our site, such as Butanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with L2HGDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Butanoate metabolismBDH1;HADH;ECHS1;L2HGDH;HADHAB;HADHAA;ACSM2B;Acsm2a;ALDH5A1

L2HGDH has several biochemical functions, for example, 2-hydroxyglutarate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by L2HGDH itself. We selected most functions L2HGDH had, and list some proteins which have the same functions with L2HGDH. You can find most of the proteins on our site.

Function Related Protein
2-hydroxyglutarate dehydrogenase activity

L2HGDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with L2HGDH here. Most of them are supplied by our site. Hope this information will be useful for your research of L2HGDH.

ATL3

Research Area

Related articles

Shim, EH; Livi, CB; et al. L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer. CANCER DISCOVERY 4:1290-1298(2014).
Balaji, P; Viswanathan, V; et al. An interesting case of metabolic dystonia: L-2 hydroxyglutaric aciduria. ANNALS OF INDIAN ACADEMY OF NEUROLOGY 17:97-99(2014).
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