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LIN28B

  • Official Full Name

    lin-28 homolog B

  • Overview

    LIN28A and LIN28B are conserved, developmentally regulated RNA binding proteins that inhibit the processing and maturation of the let-7 family of miRNAs. The let-7 miRNAs have been implicated in repression of oncogenes such as ras, myc, and Hmga2. It has
  • Synonyms

    LIN28B; lin-28 homolog B (C. elegans); protein lin-28 homolog B; CSDD2; FLJ16517; lin-28B; Lin-28.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • C
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • FLAG
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LIN28B-7186H Recombinant Human Lin-28 Homolog B (C. elegans), His-tagged E.coli His 1-250aa
Human LIN28B-1034H Recombinant Human LIN28B Mammalian Cell His
Human LIN28B-4733HCL Recombinant Human LIN28B 293 Cell Lysate HEK293 N/A
Human LIN28B-3365H Recombinant Human LIN28B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LIN28B-09H Recombinant Human LIN28B Protein (2-250), N-FLAG/Avi-tagged, Biotin-labeled HEK293 N-FLAG and Avi 2-250
Human LIN28B-11H Recombinant Human LIN28B Protein(151-250aa), His-tagged E.coli C-His 151-250aa
Human LIN28B-3365H-B Recombinant Human LIN28B Protein Pre-coupled Magnetic Beads HEK293
Mouse LIN28B-9113M Recombinant Mouse LIN28B Protein Mammalian Cell His
Mouse LIN28B-5090M Recombinant Mouse LIN28B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LIN28B-5090M-B Recombinant Mouse LIN28B Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LIN28B-8475Z Recombinant Zebrafish LIN28B Mammalian Cell His
Chicken LIN28B-3276C Recombinant Chicken LIN28B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LIN28B Related Articles

LIN28B involved in several pathways and played different roles in them. We selected most pathways LIN28B participated on our site, such as Cardiac Progenitor Differentiation, Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN28B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cardiac Progenitor DifferentiationLIN28A;BMP1;SIRPA;TBX5;NIPAL1;NOG;TBX20;SOX1;IRX4
Validated targets of C-MYC transcriptional activationMINA;HUWE1;LIN28B;MYCT1;PDCD10;PRDX3;PEG10;DDX18;CDCA7

LIN28B has several biochemical functions, for example, DNA binding, RNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN28B itself. We selected most functions LIN28B had, and list some proteins which have the same functions with LIN28B. You can find most of the proteins on our site.

Function Related Protein
DNA bindingSMARCB1;HOXA2B;KLF9;ZNF383;ANO9A;ZNF574;CENPA;RORA;POU3F1
RNA bindingTUT1;SKIV2L;ZFP385C;DDX19A;FMR1;RPS7;DIS3;RPLP1;NR0B1
poly(A) RNA bindingMRPL28;MAPRE1;PTBP1;PRR3;RBM7;NTPCR;DEK;CTNNA1;NCBP1
protein bindingHELLS;SPTA1;ROS1;OAZ2;OSBPL7;UBE2E1;NEDD8;PLEKHB2;CHID1
zinc ion bindingMEP1A;ZRANB1;MTA2;TRIM6;RXRBB;MKRN3;PDXK;PRKCBB;C6AST3

LIN28B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN28B here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN28B.

pre-let-7a; YBX1; pre-mir-107; ZCCHC11; USP36; ssrna_cg

Williams, KA; Labidi-Galy, SI; et al. Prognostic significance and predictors of the neutrophil-to-lymphocyte ratio in ovarian cancer. GYNECOLOGIC ONCOLOGY 132:542-550(2014).
Helland, A; Anglesio, MS; et al. Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers. PLOS ONE 6:-(2011).
Guo, YQ; Chen, YX; et al. Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma. GENE 384:51-61(2006).
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