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LONP1

  • Official Full Name

    lon peptidase 1, mitochondrial

  • Overview

    This gene encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription.
  • Synonyms

    LONP1; lon peptidase 1, mitochondrial; protease, serine, 15 , PRSS15; lon protease homolog, mitochondrial; hLON; LonHS; PIM1; Serine protease 15; hLON ATP dependent protease; Lon protease like protein; LONP; MGC1498; PRSS15; LON; LON protease; Mitochondrial ATP dependent protease Lon; Mitochondrial lon peptidase 1; Protease serine 15; protease, serine, 15; Lon protease-like protein; hLON ATP-dependent protease; mitochondrial lon protease-like protein; mitochondrial ATP-dependent protease Lon;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LONP1-1423HCL Recombinant Human LONP1 cell lysate N/A
Human LONP1-4737H Recombinant Human LONP1 Protein, GST-tagged Wheat Germ GST
Human LONP1-5956HF Recombinant Full Length Human LONP1 Protein, GST-tagged In Vitro Cell Free System GST 959 amino acids
Human LONP1-31H Recombinant Human LONP1 protein, His-tagged E.coli His 614-959 aa
Human LONP1-32H Recombinant Human LONP1 protein, GST-tagged E.coli GST 614-959 aa
Mouse LONP1-9178M Recombinant Mouse LONP1 Protein Mammalian Cell His
Mouse LONP1-5127M Recombinant Mouse LONP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LONP1-5127M-B Recombinant Mouse LONP1 Protein Pre-coupled Magnetic Beads HEK293
Rat LONP1-3431R Recombinant Rat LONP1 Protein Mammalian Cell His
Rat LONP1-3087R Recombinant Rat LONP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LONP1-3087R-B Recombinant Rat LONP1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LONP1 Related Articles

LONP1 involved in several pathways and played different roles in them. We selected most pathways LONP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LONP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

LONP1 has several biochemical functions, for example, ADP binding, ATP binding, ATP-dependent peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LONP1 itself. We selected most functions LONP1 had, and list some proteins which have the same functions with LONP1. You can find most of the proteins on our site.

Function Related Protein
ADP bindingPRKAG1;PRPS2;GCLC;ATP1A1;MYO7A;CYB5R3;P2RY1;MYO18A;PRKAG2
ATP bindingGUK1;YTHDC2;WRN;ADCK3;MAPK14A;ATP2A2;UBE2I;P2RX4A;ERN2
ATP-dependent peptidase activityLONP1;SPG7;LONRF1L;LONRF3;YME1L1;AFG3L2;LONRF2;CRBN
DNA polymerase bindingACD;SMARCA4;FANCD2;PCNA;HMGB1;RAD51;LONP1;FANCI;CDK2AP1
G-quadruplex DNA bindingDHX36;BLM;LONP1;WRN
mitochondrial heavy strand promoter anti-sense binding
NOT mitochondrial heavy strand promoter sense binding
mitochondrial light strand promoter anti-sense binding
NOT mitochondrial light strand promoter sense binding
protein bindingASGR2;CST1;HIST2H3C2;ZFYVE9;PEF1;IGFBP2;SP1;ZGPAT;TDO2
sequence-specific DNA bindingNR3C2;SHOX2;ZC3H8;HOXD11;FOXP4;KLF2;EMX1;HOXC9;DMRT2
serine-type endopeptidase activityHGFA;GM5077;PROC;HTRA4;KLK6;KLK15;PRSS33;TPP1;PRSS50
single-stranded DNA bindingXRCC3;XRCC2;TSN;CRY2;TEN1;NME2;CNBP;SWSAP1;TTC6
single-stranded RNA bindingPOLR2GL;A1CF;NXF1;ZFP36;LUZP4;IFIT5;AGO3;IFIH1;HNRNPA1

LONP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LONP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LONP1.

CSN2; USP2; TSC22D1; MAP3K3; ATG101; IFIT3; A2M; CYP2C8; IFIT5; CDC37; fumA; LOXL4; ECSIT; RNF32

Strauss, KA; Jinks, RN; et al. CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA(+) Lon Protease. AMERICAN JOURNAL OF HUMAN GENETICS 96:121-135(2015).
Goo, HG; Rhim, H; et al. HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis. EXPERIMENTAL CELL RESEARCH 328:456-465(2014).
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