LONP1
-
Official Full Name
lon peptidase 1, mitochondrial -
Overview
This gene encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription. -
Synonyms
LONP1;lon peptidase 1, mitochondrial;protease, serine, 15 , PRSS15;lon protease homolog, mitochondrial;hLON;LonHS;PIM1;Serine protease 15;hLON ATP dependent protease;Lon protease like protein;LONP;MGC1498;PRSS15;LON;LON protease;Mitochondrial ATP dependent protease Lon;Mitochondrial lon peptidase 1;Protease serine 15;protease, serine, 15;Lon protease-like protein;hLON ATP-dependent protease;mitochondrial lon protease-like protein;mitochondrial ATP-dependent protease Lon
Recombinant Proteins
- Rat
- Mouse
- Human
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- GST
- Myc
Involved Pathway
LONP1 involved in several pathways and played different roles in them. We selected most pathways LONP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with LONP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
LONP1 has several biochemical functions, for example, ADP binding,ATP binding,ATP-dependent peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LONP1 itself. We selected most functions LONP1 had, and list some proteins which have the same functions with LONP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-quadruplex DNA binding | WRN,DHX36,BLM |
| serine-type endopeptidase activity | CTSG,PRSS12,CELA3A,KLK2,GZMH,PARL,F7I,F12,RHBDD1,PRSS37 |
| single-stranded RNA binding | RBMX,LUZP4,TLR7,JMJD6,ENDOV,POLR2GL,A1CF,LSM14A,AGO2,ANXA1 |
| ADP binding | PRKAG2,MIEF1,ADCK3,ACTA1,PKM,VCP,GLUD1,MYH10,ABCG1,MYO9B |
| protein binding | ZBTB1,PCDHA4,PPP1R7,ETS1,MAPK8IP3,COMT,SRSF5,HTR1B,SMURF1,SUMO3 |
| ATP-dependent peptidase activity | SPG7,LONRF2,LONRF1L,LONRF3,YME1L1,AFG3L2,CRBN |
| sequence-specific DNA binding | SIX1A,DMRTA2,HOXA11A,NKX2-6,SIX1B,PBX1B,IRX4B,HOXA5A,NKX1.2LB,MSXB |
| ATP binding | PGS1,DDX43,PRPF4BA,ABCC9,CSNK2A2A,MYHZ1.2,PAPSS2,CAMKK1,MARK4,LRRK1 |
| DNA polymerase binding | SMARCA4,HMGB1,CDK2AP1,RAD51,FANCD2,FANCI,ACD,PCNA |
Interacting Protein
LONP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LONP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LONP1.
CSN2;USP2;TSC22D1;MAP3K3;ATG101;IFIT3;A2M;CYP2C8;IFIT5;CDC37;fumA;LOXL4;ECSIT;RNF32
Resources
Related Services
Related Products
References
- Strauss, KA; Jinks, RN; et al. CODAS Syndrome Is Associated with Mutations of LONP1, Encoding Mitochondrial AAA(+) Lon Protease. AMERICAN JOURNAL OF HUMAN GENETICS 96:121-135(2015).
- Goo, HG; Rhim, H; et al. HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis. EXPERIMENTAL CELL RESEARCH 328:456-465(2014).
