|Official Full Name||low density lipoprotein receptor-related protein 8, apolipoprotein e receptor|
|Background||This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are;cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific;ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during;development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein;apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced;transcript variants encoding multiple isoforms have been observed for this gene.|
|Synonyms||LRP8; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; low-density lipoprotein receptor-related protein 8; APOER2; ApoE receptor 2; MCI1; LRP-8; HSZ75190|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
LRP8 involved in several pathways and played different roles in them. We selected most pathways LRP8 participated on our site, such as Signaling events mediated by PRL, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Signaling events mediated by PRL||LRP8; RABGGTA; RABGGTB; ATF5; PTP4A1; PTP4A2; PTP4A3|
LRP8 has several biochemical functions, for example, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LRP8 itself. We selected most functions LRP8 had, and list some proteins which have the same functions with LRP8. You can find most of the proteins on our site.
|protein tyrosine phosphatase activity||PTPREB; DUSP14; MTMR7; PTPRM; PTEN; DUSP6; SSH2; DUSP15; DUSP28; MTMR7A|
|protein tyrosine/serine/threonine phosphatase activity||DUSP14; DUSP15; DUSP19A; SSH3; SACM1LB; EYA3; CDC14AA; PTPRQ; SSH2B; DUSP23A|
LRP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRP8.
APOE; SS18; TYK2; USP11; Pten; ALB; RAD51; ANGEL2; CRTC3; GHDC; C19orf47; PRCC; DOCK6; ARHGAP39; PRKRIP1; CAMSAP3; PPP1R9A