MAD2L2
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Official Full Name
MAD2 mitotic arrest deficient-like 2
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Overview
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. -
Synonyms
MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast); MAD2 (mitotic arrest deficient, yeast, homolog) like 2; mitotic spindle assembly checkpoint protein MAD2B; MAD2B; mitotic arrest deficient homolog like 2; REV7; hREV7; REV7 homolog; MAD2-like protein 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
MAD2L2 involved in several pathways and played different roles in them. We selected most pathways MAD2L2 participated on our site, such as Bacterial invasion of epithelial cells, Cell cycle, DNA Damage Bypass, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAD2L2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bacterial invasion of epithelial cells | FN1;ELMO2;RAC1;ARPC5L;ARPC3;WASF1;SHC4;ELMO3;SEPT9 |
| Cell cycle | NIPBLB;GINS4;SPC24;ORC2L;CETN2;BANF1;ORC3;MCM6;CENPL |
| DNA Damage Bypass | POLD3;DTL;USP43;ZBTB32;SPRTN;USP10;RAD18;UBE2L6;DDB1 |
| DNA Repair | MAD2L2;PARP1;BRE;ACTL6A;TIPIN;ASCC1;COPS6;ZBTB32;GEN1 |
| Oocyte meiosis | YWHAE2;ANAPC2;PPP1CAA;RPS6KA3B;SMC1AL;PPP3CB;ADCY1A;YWHAE;MAPK1 |
| Progesterone-mediated oocyte maturation | RPS6KA2;FZR1;CDC26;CCNA2;PLK1;INS;RPS6KA3;MAPK11;GNAI3 |
| Shigellosis | MAPK13;NFKBIB;ABL1;WASL;PFN3;ROCK1;WASF1;MAD2L2;RIPK2 |
| Translesion synthesis by POLI | POLI;MAD2L2 |
MAD2L2 has several biochemical functions, for example, JUN kinase binding, RNA polymerase II activating transcription factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAD2L2 itself. We selected most functions MAD2L2 had, and list some proteins which have the same functions with MAD2L2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| JUN kinase binding | PTK2;MAD2L2;MAPK8IP3;GSTP1;SPAG9;SPAG9A |
| RNA polymerase II activating transcription factor binding | SMAD3;MAD2L2;POU1F1;DUSP26;JUN;ISL1;CREBBP;IFI27;LDB1 |
| protein binding | KLHDC4;ARMC9;SEC14L4;DDX18;EVC2;CAB39;RAPGEF4;TRMT112;DPYSL4 |
MAD2L2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAD2L2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAD2L2.
CHAMP1; REV3L; ADAM9; ipaB; SFI1
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