Map3k1

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

  • Overview

    MEKK1 is member of the serine/threonine protein kinase family and is a target in the JNK and ERK pathways. Phosphorylation of MEKK1 works with other kinases to activate cellular responses to mitogenic and metabolic stimuli.
  • Synonyms

    MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; MEKK1, mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; MAPKKK1; MEKK; MEK kinase 1; MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEKK1; SRXY6; MEKK 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP3K1-1037H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 1, GST-Tagged Sf9 Insect Cell GST
Human MAP3K1-30190TH Recombinant Human MAP3K1 Sf9 Insect Cell N/A 849 amino acids
Human MAP3K1-1540H Recombinant Human MAP3K1 protein, His & T7-tagged E.coli His/T7 Ile1307~Arg1509 (Accession # Q13233)
Human MAP3K1-393H Recombinant Human MAP3K1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAP3K1-1357H Recombinant Human MAP3K1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP3K1-1515HFL Recombinant Full Length Human MAP3K1 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP3K1-1357H-B Recombinant Human MAP3K1 Protein Pre-coupled Magnetic Beads HEK293
Human MAP3K1-2121H Recombinant Human MAP3K1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAP3K1-4533H Recombinant Human MAP3K1 Protein (Ile1307-Arg1509), N-His tagged E.coli N-His Ile1307-Arg1509
Mouse Map3k1-3204M Recombinant Mouse Map3k1 protein, His-tagged E.coli His 1216-1493aa
Mouse Map3k1-3926M Recombinant Mouse Map3k1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Map3k1-665R Active Recombinant Rat Mitogen Activated Protein Kinase Kinase Kinase 1 E.coli N/A
Rat MAP3K1-3563R Recombinant Rat MAP3K1 Protein Mammalian Cell His
Rat MAP3K1-3219R-B Recombinant Rat MAP3K1 Protein Pre-coupled Magnetic Beads HEK293
Rat MAP3K1-3219R Recombinant Rat MAP3K1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Map3k1 involved in several pathways and played different roles in them. We selected most pathways Map3k1 participated on our site, such as MAPK signaling pathway, Ubiquitin mediated proteolysis, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map3k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayARRB2;FGF11A;CACNA1B;FLNA;PPP3CA;MAPKAPK2;JUND;HSP70;HSPA2
Ubiquitin mediated proteolysisUBE2QL1;KEAP1B;HERC2;SMURF1;UBE2E3;CBLC;NHLRC1;UBA1;UBE2KA
RIG-I-like receptor signaling pathwayMAPK11;IL8L2;IFNA7;AZI2;IL12BA;RIPK1;FADD;DDX3X;TBKBP1
Neurotrophin signaling pathwayNFKBIE;MAPK10;CALM4;MAPK13;NFKBIB;PRKCD;ATF4;CALM1;SHC1
GnRH signaling pathwayLHB;MAPK12;MAPK8;PRKACBB;MAPK10;MMP14A;MAPK11;PLCB4;ADCY1B
Hepatitis BPIK3CA;PIK3R5;RAF1;TRP53;STAT4;IL6;IFNA14;CCNA2;BCL2
HTLV-I infectionCALR;HLA-DPA1;IL1R1;PIK3CD;FOSL1;PTTG1;POLB;ATF4;ANAPC2

Map3k1 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Map3k1 itself. We selected most functions Map3k1 had, and list some proteins which have the same functions with Map3k1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingIGF1R;PRKCA;ATP1A1A.3;CASK;PIM2;SMARCA4;TOP2B;TNIK;PAICS
JUN kinase kinase kinase activityMAP3K11;ALPK2;MAP3K10;MAP3K1;MAP3K9
MAP kinase kinase kinase activityMAP3K4;MAP3K1;YSK4;EGFR;KIAA1804;MOS;BRAF;MAP3K15;ZAK
protein bindingEVL;PIP;NFKBIL2;TTC25;AIM2;RIBC2;PIK3C3;ZNF193;ARF5
protein kinase activityMAP4K3;PRKCG;FYNB;RBM4.3;STK30;GRK1;PRKCD;Aatk;NEK4
protein kinase bindingAP1B1;SLC12A5;SLC12A4;HNRNPA0;SPRED2;PTPRC;NEFH;PRKAG2;CD8A
zinc ion bindingPHC1;ING5A;PHF19;BMP1;MAN2C1;PIAS4;PITRM1;MLL5;TRIM13

Map3k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map3k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map3k1.

DCAF7; YWHAE; BRAF; MAP2K4; HSPA1L; TRAF2; ARRB2

Research Area

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is MAP3K1 protein expression measured in clinical settings? 08/29/2021

MAP3K1 protein expression can be measured using immunohistochemistry (IHC) or Western blotting in clinical settings.

Are there any diseases associated with MAP3K1 protein mutations? 08/21/2021

Yes, mutations in the MAP3K1 gene have been linked to several diseases, including breast cancer, lung cancer, and colon cancer.

What are the implications of MAP3K1 protein in drug resistance? 06/29/2021

MAP3K1 protein has been implicated in the development of drug resistance in certain cancer types, highlighting its importance in personalized medicine and treatment response.

What are the potential diagnostic applications of MAP3K1 protein analysis? 01/05/2021

MAP3K1 protein analysis can be used for diagnostic purposes to identify specific molecular subtypes of cancer and to predict disease prognosis.

How is MAP3K1 protein targeted in precision medicine approaches? 04/19/2017

Precision medicine approaches may involve targeting MAP3K1 protein through specific inhibitors or monoclonal antibodies to inhibit its oncogenic activity.

Customer Reviews (3)

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Reviews
12/20/2020

    The bands of proteins in Western Blotting experiments were very clear.

    11/10/2020

      The MAP3K1 protein is highly recommended for its exceptional performance in ELISA assays.

      09/30/2017

        Researchers can rely on the MAP3K1 protein to deliver precise results, enhancing the credibility and efficiency of their experiments.

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