Map3k1
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Official Full Name
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
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Overview
MEKK1 is member of the serine/threonine protein kinase family and is a target in the JNK and ERK pathways. Phosphorylation of MEKK1 works with other kinases to activate cellular responses to mitogenic and metabolic stimuli. -
Synonyms
MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; MEKK1, mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; MAPKKK1; MEKK; MEK kinase 1; MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEKK1; SRXY6; MEKK 1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Map3k1 involved in several pathways and played different roles in them. We selected most pathways Map3k1 participated on our site, such as MAPK signaling pathway, Ubiquitin mediated proteolysis, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map3k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | ARRB2;FGF11A;CACNA1B;FLNA;PPP3CA;MAPKAPK2;JUND;HSP70;HSPA2 |
| Ubiquitin mediated proteolysis | UBE2QL1;KEAP1B;HERC2;SMURF1;UBE2E3;CBLC;NHLRC1;UBA1;UBE2KA |
| RIG-I-like receptor signaling pathway | MAPK11;IL8L2;IFNA7;AZI2;IL12BA;RIPK1;FADD;DDX3X;TBKBP1 |
| Neurotrophin signaling pathway | NFKBIE;MAPK10;CALM4;MAPK13;NFKBIB;PRKCD;ATF4;CALM1;SHC1 |
| GnRH signaling pathway | LHB;MAPK12;MAPK8;PRKACBB;MAPK10;MMP14A;MAPK11;PLCB4;ADCY1B |
| Hepatitis B | PIK3CA;PIK3R5;RAF1;TRP53;STAT4;IL6;IFNA14;CCNA2;BCL2 |
| HTLV-I infection | CALR;HLA-DPA1;IL1R1;PIK3CD;FOSL1;PTTG1;POLB;ATF4;ANAPC2 |
Map3k1 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Map3k1 itself. We selected most functions Map3k1 had, and list some proteins which have the same functions with Map3k1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | IGF1R;PRKCA;ATP1A1A.3;CASK;PIM2;SMARCA4;TOP2B;TNIK;PAICS |
| JUN kinase kinase kinase activity | MAP3K11;ALPK2;MAP3K10;MAP3K1;MAP3K9 |
| MAP kinase kinase kinase activity | MAP3K4;MAP3K1;YSK4;EGFR;KIAA1804;MOS;BRAF;MAP3K15;ZAK |
| protein binding | EVL;PIP;NFKBIL2;TTC25;AIM2;RIBC2;PIK3C3;ZNF193;ARF5 |
| protein kinase activity | MAP4K3;PRKCG;FYNB;RBM4.3;STK30;GRK1;PRKCD;Aatk;NEK4 |
| protein kinase binding | AP1B1;SLC12A5;SLC12A4;HNRNPA0;SPRED2;PTPRC;NEFH;PRKAG2;CD8A |
| zinc ion binding | PHC1;ING5A;PHF19;BMP1;MAN2C1;PIAS4;PITRM1;MLL5;TRIM13 |
Map3k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map3k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map3k1.
DCAF7; YWHAE; BRAF; MAP2K4; HSPA1L; TRAF2; ARRB2
Research Area
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe bands of proteins in Western Blotting experiments were very clear.
The MAP3K1 protein is highly recommended for its exceptional performance in ELISA assays.
Researchers can rely on the MAP3K1 protein to deliver precise results, enhancing the credibility and efficiency of their experiments.
Q&As (5)
Ask a questionMAP3K1 protein expression can be measured using immunohistochemistry (IHC) or Western blotting in clinical settings.
Yes, mutations in the MAP3K1 gene have been linked to several diseases, including breast cancer, lung cancer, and colon cancer.
MAP3K1 protein has been implicated in the development of drug resistance in certain cancer types, highlighting its importance in personalized medicine and treatment response.
MAP3K1 protein analysis can be used for diagnostic purposes to identify specific molecular subtypes of cancer and to predict disease prognosis.
Precision medicine approaches may involve targeting MAP3K1 protein through specific inhibitors or monoclonal antibodies to inhibit its oncogenic activity.
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