|Official Full Name||mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase|
|Background||MEKK1 is member of the serine/threonine protein kinase family and is a target in the JNK and ERK pathways. Phosphorylation of MEKK1 works with other kinases to activate cellular responses to mitogenic and metabolic stimuli.|
|Synonyms||MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; MEKK1, mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; MAPKKK1; MEKK; MEK kinase 1; MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEKK1; SRXY6; MEKK 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
Map3k1 involved in several pathways and played different roles in them. We selected most pathways Map3k1 participated on our site, such as MAPK signaling pathway, Ubiquitin mediated proteolysis, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map3k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|MAPK signaling pathway||HSPB1; RAP1A; GNA12; MAP2K2A; CACNA1DA; FGF1B; Fasl; Fgf15; FOS; CACNG1A|
|Ubiquitin mediated proteolysis||PRP19; NHLRC1; SIAH1; TRIP12; FANCL; CBLB; ANAPC1; UBE2IB; SMURF2; CUL4A|
|RIG-I-like receptor signaling pathway||IFNPHI3; CXCL10; AZI2; TRAF6; MAPK12B; RIPK1L; NFKBIAB; PL10; NFKBIB; IFNE|
|Neurotrophin signaling pathway||SH2B3; CAMK2A; BCL2; MAP2K2; RAP1B; SH2B2; BAX; AKT1; RHOA; TRAF6|
|GnRH signaling pathway||MAPK8; LHB; CACNA1D; EGFRA; GNRHR; CALM1; ADCY2B; PRKACBB; MAPK13; HRASB|
|Hepatitis B||YWHAB; IFNA16; IFNA2; DDX58; IFIH1; TRP53; IFN-a; VDAC3; IRF3; BCL2|
|HTLV-I infection||DVL1; PCNA; FOS; H2-AA; MAP3K14; KRAS; NFATC3; FZD3; MAPK8; MAP3K3|
Map3k1 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Map3k1 itself. We selected most functions Map3k1 had, and list some proteins which have the same functions with Map3k1. You can find most of the proteins on our site.
|ATP binding||ABCG2A; ATP7B; DDX55; RUNX2B; GTF2F2B; PYGL; GALK1; SGK2A; RUNX3; TRPV1|
|JUN kinase kinase kinase activity||MAP3K10; ALPK2; MAP3K9; MAP3K11; MAP3K1|
|MAP kinase kinase kinase activity||BRAF; TAOK1; MAP3K8; MAP3K2; MAP3K15; MOS; MAP3K3; MAP3K5; TAOK2; EGFR|
|protein binding||TMEM123; PHOSPHO2-KLHL23; RTN4; TRIM22; DYRK1A; LRRC4; MBD3; MIS18BP1; PLEKHG6; KPNB1|
|protein kinase activity||EIF2AK3; PDK2; SMOK2B; GSK3AA; NLK1; POMK; TNIK; MAP4K1; LMTK2; TAOK1|
|protein kinase binding||MSN; CDK5RAP1; DUSP3; GDF3; ADRA2A; MAP2K3; GRIN2A; KIF11; CCNY; NR4A3|
|zinc ion binding||RNF4; TRAF6; RNF26; TADA2A; RNF185; ADA; TRIM15; SLC30A8; L3MBTL1; ZCCHC18|
Map3k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map3k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map3k1.
DCAF7; YWHAE; BRAF; MAP2K4; HSPA1L; TRAF2; ARRB2