Recombinant Human MAP3K1
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Cat.No. : | MAP3K1-30190TH Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant fragment of Human MEKK1 (amino acids 900-1748) with N-terminal proprietary tag, 155kDa. |
Description : | The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. |
Protein length : | 849 amino acids |
Molecular Weight : | 155.000kDa inclusive of tags |
Source : | Baculovirus infected sf9 cells |
Biological activity : | The Specific activity of MAP3K1-30190TH was determined to be 820 nmol/min/mg. |
Form : | Liquid |
Purity : | by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 0.01% Triton-X-100, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Contains 1 protein kinase domain.Contains 1 RING-type zinc finger.Contains 1 SWIM-type zinc finger. |
Gene Name : | MAP3K1 mitogen-activated protein kinase kinase kinase 1 [ Homo sapiens ] |
Official Symbol : | MAP3K1 |
Synonyms : | MAP3K1; mitogen-activated protein kinase kinase kinase 1; MEKK1; MAPKKK1; MEKK; |
Gene ID : | 4214 |
mRNA Refseq : | NM_005921 |
Protein Refseq : | NP_005912 |
MIM : | 600982 |
Uniprot ID : | Q13233 |
Chromosome Location : | 5q11.2 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis Modulation by HSP70, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem; |
Function : | ATP binding; JUN kinase binding; JUN kinase kinase activity; JUN kinase kinase kinase activity; MAP kinase kinase kinase activity; |
◆ Recombinant Protein
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MAP3K1-3563R | Recombinant Rat MAP3K1 Protein | +Inquiry |
Map3k1-3204M | Recombinant Mouse Map3k1 protein, His-tagged | +Inquiry |
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