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Recombinant Human MAP3K1

Cat.No. : MAP3K1-30190TH
Product Overview : Recombinant fragment of Human MEKK1 (amino acids 900-1748) with N-terminal proprietary tag, 155kDa.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins.
Protein length : 849 amino acids
Molecular Weight : 155.000kDa inclusive of tags
Source : Baculovirus infected sf9 cells
Biological activity : The Specific activity of MAP3K1-30190TH was determined to be 820 nmol/min/mg.
Form : Liquid
Purity : by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 0.01% Triton-X-100, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Contains 1 protein kinase domain.Contains 1 RING-type zinc finger.Contains 1 SWIM-type zinc finger.
Gene Name : MAP3K1 mitogen-activated protein kinase kinase kinase 1 [ Homo sapiens ]
Official Symbol : MAP3K1
Synonyms : MAP3K1; mitogen-activated protein kinase kinase kinase 1; MEKK1; MAPKKK1; MEKK;
Gene ID : 4214
mRNA Refseq : NM_005921
Protein Refseq : NP_005912
MIM : 600982
Uniprot ID : Q13233
Chromosome Location : 5q11.2
Pathway : Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis Modulation by HSP70, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; CD40/CD40L signaling, organism-specific biosystem;
Function : ATP binding; JUN kinase binding; JUN kinase kinase activity; JUN kinase kinase kinase activity; MAP kinase kinase kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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