Recombinant Full Length Human MAP3K1 Protein, C-Flag-tagged

Cat.No. : MAP3K1-1515HFL
Product Overview : Recombinant Full Length Human MAP3K1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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Description : The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 164.3 kDa
AA Sequence : MAAAAGNRASSSGFPGARATSPEAG GGGGALKASSAPAAAAGLLREAGSG GRERADWRRRQLRKVRSVEL DQLPEQPLFLAASPPASSTSPSPEP ADAAGSGTGFQPVAVPPPHGAASRG GAHLTESVAAPDSGASSPAA AEPGEKRAPAAEPSPAAAPAGREME NKETLKGLHKMDDRPEERMIREKLK ATCMPAWKHEWLERRNRRGP VVVKPIPVKGDGSEMNHLAAESPGE VQASAASPASKGRRSPSPGNSPSGR TVKSESPGVRRKRVSPVPFQ SGRITPPRRAPSPDGFSPYSPEETN RRVNKVMRARLYLLQQIGPNSFLIG GDSPDNKYRVFIGPQNCSCA RGTFCIHLLFVMLRVFQLEPSDPML WRKTLKNFEVESLFQKYHSRRSSRI KAPSRNTIQKFVSRMSNSHT LSSSSTSTSSSENSIKDEEEQMCPI CLLGMLDEESLTVCEDGCRNKLHHH CMSIWAEECRRNREPLICPL CRSKWRSHDFYSHELSSPVDSPSSL RAAQQQTVQQQPLAGSRRNQESNFN LTHYGTQQIPPAYKDLAEPW IQVFGMELVGCLFSRNWNVREMALR RLSHDVSGALLLANGESTGNSGGSS GSSPSGGATSGSSQTSISGD VVEACCSVLSMVCADPVYKVYVAAL KTLRAMLVYTPCHSLAERIKLQRLL QPVVDTILVKCADANSRTSQ LSISTLLELCKGQAGELAVGREILK AGSIGIGGVDYVLNCILGNQTESNN WQELLGRLCLIDRLLLEFPA EFYPHIVSTDVSQAEPVEIRYKKLL SLLTFALQSIDNSHSMVGKLSRRIY LSSARMVTTVPHVFSKLLEM LSVSSSTHFTRMRRRLMAIADEVEI AEAIQLGVEDTLDGQQDSFLQASVP NNYLETTENSSPECTVHLEK TGKGLCATKLSASSEDISERLASIS VGPSSSTTTTTTTTEQPKPMVQTKG RPHSQCLNSSPLSHHSQLMF PALSTPSSSTPSVPAGTATDVSKHR LQGFIPCRIPSASPQTQRKFSLQFH RNCPENKDSDKLSPVFTQSR PLPSSNIHRPKPSRPTPGNTSKQGD PSKNSMTLDLNSSSKCDDSFGCSSN SSNAVIPSDETVFTPVEEKC RLDVNTELNSSIEDLLEASMPSSDT TVTFKSEVAVLSPEKAENDDTYKDD VNHNQKCKEKMEAEEEEALA IAMAMSASQDALPIVPQLQVENGED IIIIQQDTPETLPGHTKAKQPYRED TEWLKGQQIGLGAFSSCYQA QDVGTGTLMAVKQVTYVRNTSSEQE EVVEALREEIRMMSHLNHPNIIRML GATCEKSNYNLFIEWMAGGS VAHLLSKYGAFKESVVINYTEQLLR GLSYLHENQIIHRDVKGANLLIDST GQRLRIADFGAAARLASKGT GAGEFQGQLLGTIAFMAPEVLRGQQ YGRSCDVWSVGCAIIEMACAKPPWN AEKHSNHLALIFKIASATTA
PSIPSHLSPGLRDVALRCLELQPQD RPPSRELLKHPVFRTTWTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, Protein Kinase
Protein Pathways : GnRH signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, RIG-I-like receptor signaling pathway, Ubiquitin mediated proteolysis
Gene Name : MAP3K1 mitogen-activated protein kinase kinase kinase 1 [ Homo sapiens (human) ]
Official Symbol : MAP3K1
Synonyms : MEKK; MEKK1; SRXY6; MEKK 1; MAPKKK1
Gene ID : 4214
mRNA Refseq : NM_005921.2
Protein Refseq : NP_005912.1
MIM : 600982
UniProt ID : Q13233

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How is MAP3K1 protein expression measured in clinical settings? 08/29/2021

MAP3K1 protein expression can be measured using immunohistochemistry (IHC) or Western blotting in clinical settings.

Are there any diseases associated with MAP3K1 protein mutations? 08/21/2021

Yes, mutations in the MAP3K1 gene have been linked to several diseases, including breast cancer, lung cancer, and colon cancer.

What are the implications of MAP3K1 protein in drug resistance? 06/29/2021

MAP3K1 protein has been implicated in the development of drug resistance in certain cancer types, highlighting its importance in personalized medicine and treatment response.

What are the potential diagnostic applications of MAP3K1 protein analysis? 01/05/2021

MAP3K1 protein analysis can be used for diagnostic purposes to identify specific molecular subtypes of cancer and to predict disease prognosis.

How is MAP3K1 protein targeted in precision medicine approaches? 04/19/2017

Precision medicine approaches may involve targeting MAP3K1 protein through specific inhibitors or monoclonal antibodies to inhibit its oncogenic activity.

Customer Reviews (3)

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Reviews
12/20/2020

    The bands of proteins in Western Blotting experiments were very clear.

    11/10/2020

      The MAP3K1 protein is highly recommended for its exceptional performance in ELISA assays.

      09/30/2017

        Researchers can rely on the MAP3K1 protein to deliver precise results, enhancing the credibility and efficiency of their experiments.

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