MAP3K10

  • Official Full Name

    mitogen-activated protein kinase kinase kinase 10

  • Overview

    The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
  • Synonyms

    MAP3K10; mitogen-activated protein kinase kinase kinase 10; MLK2; MEKK10; mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MST; protein kinase MST;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • HEK293
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP3K10-1256H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, His-tagged Sf9 Insect Cell His
Human MAP3K10-30247TH Recombinant Human MAP3K10 Wheat Germ N/A
Human MAP3K10-1038H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, GST-Tagged Sf9 Insect Cell GST
Human MAP3K10-462H Recombinant Human MAP3K10 Mammalian Cell His
Human MAP3K10-3432H Recombinant Human MAP3K10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP3K10-3432H-B Recombinant Human MAP3K10 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP3K10 Related Articles
  • MAP3K10 Related Research Area

MAP3K10 involved in several pathways and played different roles in them. We selected most pathways MAP3K10 participated on our site, such as Insulin Signaling, p38 MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Insulin SignalingRRAD;MYO1C;CAP1;MAPK4;KIF5B;MAP3K10;MINK1;GSK3AB;MAP3K9
p38 MAPK signaling pathwayGADD45G;MAP3K9;MAP3K10

MAP3K10 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K10 itself. We selected most functions MAP3K10 had, and list some proteins which have the same functions with MAP3K10. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDARS;FANCM;ATP12A;RIOK3;ACSS3;CAMK1DB;ROS1;CLPXA;ATP2B2
JUN kinase kinase kinase activityMAP3K10;ALPK2;MAP3K9;MAP3K11;MAP3K1
bHLH transcription factor bindingTWIST1;SOX9;MAP3K10;ISL1;FOXH1;RUNX2;TCF3B;EP300;TCF21
protein homodimerization activityMBL1;CADM1B;MTHFD1L;NDP;UGT1A6B;TIMM9;PVALB;RIPK2;PVRL1A
protein kinase activityIRAK4;INSRA;ROCK2A;TNNI3K;FYNB;TNIK;MMD;CLK4B;AURKC
protein serine/threonine kinase activityCSNK1D;MAP3K11;BCR;ROCK1;KSR2;AAK1;CSNK1E;ACVR1BA;ADCK5
transcription corepressor activityNR0B1;NSD1;CTCF;KLF12;SSX1;PIAS1;TLE4;BASP1;RYBP

MAP3K10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K10.

GARS; ABL2; MLK4

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).
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