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MAP3K10

Official Full Name

mitogen-activated protein kinase kinase kinase 10
Overview

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
Synonyms

MAP3K10; mitogen-activated protein kinase kinase kinase 10; MLK2; MEKK10; mixed lineage kinase 2; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; MST; protein kinase MST;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Human

Source

HEK293
Mammalian Cell
Sf21
Sf9 Insect Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAP3K10-153H	Active Recombinant Human MAP3K10(1-449) Protein, N-His-tagged	Sf21	His	1-449 aa	Inquiry
Human	MAP3K10-30247TH	Recombinant Human MAP3K10	Wheat Germ	N/A	100 amino acids	Inquiry
Human	MAP3K10-1256H	Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, His-tagged	Sf9 Insect Cell	His		Inquiry
Human	MAP3K10-1038H	Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, GST-Tagged	Sf9 Insect Cell	GST		Inquiry
Human	MAP3K10-462H	Recombinant Human MAP3K10	Mammalian Cell	His		Inquiry
Human	MAP3K10-3432H	Recombinant Human MAP3K10 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	MAP3K10-3432H-B	Recombinant Human MAP3K10 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MAP3K10 involved in several pathways and played different roles in them. We selected most pathways MAP3K10 participated on our site, such as Insulin Signaling, p38 MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Insulin Signaling	GRB10;FLOT1;RHOJ;INPP4AA;STXBP3;RRAD;GRB14;SGK2;REG1A
p38 MAPK signaling pathway	MAP3K10;MAP3K9;GADD45G

MAP3K10 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K10 itself. We selected most functions MAP3K10 had, and list some proteins which have the same functions with MAP3K10. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	EGFR;RAD51C;TSSK2;SMC6;CDC34B;EIF4A3;HSPA12B;NOLC1;STK16
JUN kinase kinase kinase activity	MAP3K1;MAP3K9;MAP3K11;ALPK2;MAP3K10
bHLH transcription factor binding	HAND1;TCF3A;SOX9;PSMD9;TCF3B;FOXH1;ASCL1;LMO2;RUNX2
protein homodimerization activity	ABP1;CISD2;EIF2AK3;TFAP2B;NPR3;SRGAP2;ACVR1;NOS2;ODZ4
protein kinase activity	Fert2;TNK2B;TLK1A;PDPK1B;WNK2;RPS6KA6;CSNK1D;MAP2K1;PDK4
protein serine/threonine kinase activity	NUAK1;CAMKK1B;MAP4K3;ARAF;ACVR1BA;MASTL;AKT3;PDK3;RIOK2
transcription corepressor activity	ZEB1;NFIL3;CBX4;ATF3;HDAC7A;DRAP1;NCOR2;TBL1XR1A;THRB

MAP3K10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K10.

GARS; ABL2; MLK4

Research Area

Apoptosis Intracellular Kinases

MAP3K

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).

Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).