MAP3K10
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Official Full Name
mitogen-activated protein kinase kinase kinase 10 -
Overview
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. -
Synonyms
MAP3K10;mitogen-activated protein kinase kinase kinase 10;MLK2;MEKK10;mixed lineage kinase 2;MKN28 derived nonreceptor_type serine/threonine kinase;MKN28 kinase;MST;protein kinase MST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MAP3K10-1038H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, GST-Tagged | Sf9 Cells | Human | GST | 1-446 a.a. |
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| MAP3K10-1256H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, His-tagged | Sf9 Cells | Human | His |
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| MAP3K10-30247TH | Recombinant Human MAP3K10 | Wheat Germ | Human | Non | 100 amino acids |
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| MAP3K10-462H | Recombinant Human MAP3K10 | Mammalian Cells | Human | His |
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| MAP3K10-3432H | Recombinant Human MAP3K10 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| MAP3K10-3432H-B | Recombinant Human MAP3K10 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
MAP3K10 involved in several pathways and played different roles in them. We selected most pathways MAP3K10 participated on our site, such as Insulin Signaling,p38 MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin Signaling | REG1A,STXBP1A,STXBP2,RRAD,MAP3K9,MAPK4,STXBP3A,MYO1C,MAP4K5,GRB14 |
| p38 MAPK signaling pathway | MAP3K9,GADD45G |
Protein Function
MAP3K10 has several biochemical functions, for example, ATP binding,JUN kinase kinase kinase activity,bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K10 itself. We selected most functions MAP3K10 had, and list some proteins which have the same functions with MAP3K10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CMPK1,ACSF3,GCLC,MTOR,TLK2,ATP6AP1,CDKL4,IQCA1,NLRP12,ACTC1 |
| protein homodimerization activity | CITED1,HRSP12,GCH1,ADD2,IKZF4,RAB11FIP4A,IKZF2,GDF7,PRPS1L1,MAP3K5 |
| protein kinase activity | PRKCBA,PIK3C3,ACVR2AA,GRK1A,MAP2K2A,LIMK1,GSK3AB,PRKAB1,RPS6KA5,PRPF4BB |
| transcription corepressor activity | SKI,LOXL2,TDP2,ELK3,ALX1,LIMD1,SFMBT1,ANKRD1,HDAC4,ARHGAP35 |
| JUN kinase kinase kinase activity | ALPK2,MAP3K11,MAP3K9,MAP3K1 |
| protein serine/threonine kinase activity | SRPK1,SQSTM1,MAPK8B,cka1,ROCK2B,PDIK1L,NEK11,DAPK3,FAM20C,MKNK2 |
| bHLH transcription factor binding | IKZF4,SOX9,BHLHE40,PSMD9,TCF3A,RUNX2,TCF21,TCF12,SIRT1,FOXH1 |
Interacting Protein
MAP3K10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K10.
GARS;ABL2;MLK4
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References
- Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).
- Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
