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Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 10, GST-Tagged

Cat.No. : MAP3K10-1038H
Product Overview : Recombinant human MAP3K10 (1-446) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Cat. No. : MAP3K10-1038H
Description : MAP3K10 or mixed-lineage kinase 2 is a member of the serine/threonine kinase family, which activates MAPK8 JNK and MKK4/SEK1. MAP3K10 itself can be phoshorylated, and activated by JNK kinases. MAP3K10 is also known as mitogen-activated protein kinase kinase kinase 10 (MAP3K10). MAP3K10 functions preferentially on the JNK signaling pathway which is involved in nerve growth factor (NGF) induced neuronal apoptosis. MAP3K10 was isolated as a cDNA fragment from MKN28 gastric cancer cell library using degenerate PCR. MAP3K10 is highly expressed in brain, skeletal muscle, and testis.
Applications : Kinase Assay, Western Blot
Molecular Weight : 76 kDa
Expression System : Sf9 insect cells using baculovirus.
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Specific Activity : 948 nmol/min/mg
Purity : > 85 %
Concentration : 0.1 ug/ul
Sequences : 1-446
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Insulin Signaling; p38 MAPK signaling pathwa
Gene Name : MAP3K10 mitogen-activated protein kinase kinase kinase 10 [ Homo sapiens ]
Official Symbol : MAP3K10
Synonyms : MAP3K10; MST; MLK2; MEKK10; mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST; EC; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; EC 2.7.11
Gene ID : 4294
mRNA Refseq : NM_002446
Protein Refseq : NP_002437
MIM : 600137
UniProt ID : Q02779
Chromosome Location : 19q13.2
Function : ATP binding; JUN kinase kinase kinase activity; MAP kinase kinase activity; nucleotide binding; protein homo- dimerization activity; protein serine/threonine kinase activity; protein tyrosine kinase activity

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