MAP4K3

  • Official Full Name

    mitogen-activated protein kinase kinase kinase kinase 3

  • Overview

    This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).
  • Synonyms

    MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3; RAB8IPL1; GLK; MAPKKKK3; MEK kinase kinase 3; MAPK/ERK kinase kinase kinase 3; germinal center kinase-like kinase; germinal center kinase-related protein kinase; MEKKK 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf21
  • DYKDDDDK
  • Flag
  • GST
  • GST,His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP4K3-392H Active Recombinant Human MAP4K3 protein, GST-tagged Insect Cell GST
Human MAP4K3-129H Active Recombinant Human MAP4K3(1-291) Protein, N-GST,C-His-tagged Sf21 GST,His 1-291 aa
Human MAP4K3-185H Recombinant Human MAP4K3 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAP4K3-728H Recombinant Human MAP4K3 Mammalian Cell His
Human MAP4K3-738H Recombinant Human MAP4K3, His-tagged E.coli His 537-873aa
Human MAP4K3-4501HCL Recombinant Human MAP4K3 293 Cell Lysate HEK293 N/A
Human MAP4K3-1301H Recombinant Human MAP4K3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAP4K3-5582HFL Recombinant Full Length Human MAP4K3 protein, Flag-tagged Mamanlian cells Flag
Human MAP4K3-3433H-B Recombinant Human MAP4K3 Protein Pre-coupled Magnetic Beads HEK293
Human MAP4K3-01H Recombinant Human MAP4K3 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human MAP4K3-3433H Recombinant Human MAP4K3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Map4k3-3934M Recombinant Mouse Map4k3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MAP4K3-3569R Recombinant Rat MAP4K3 Protein Mammalian Cell His
Rat MAP4K3-3225R-B Recombinant Rat MAP4K3 Protein Pre-coupled Magnetic Beads HEK293
Rat MAP4K3-3225R Recombinant Rat MAP4K3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MAP4K3 involved in several pathways and played different roles in them. We selected most pathways MAP4K3 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayRELA;NFKB1;CDC42;NLK;MAP3K14;FGF10A;FGF1A;FGF11;JIP1

MAP4K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K3 itself. We selected most functions MAP4K3 had, and list some proteins which have the same functions with MAP4K3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNEK10;MAPK15;TTBK1;ACSM5;TTLL3;PRKCA;HSPE1;TIMM44;ORC4
MAP kinase kinase kinase kinase activityMAP4K1;MAP4K6;MAP4K2;MAP4K5;MAP4K3;ALPK2
protein bindingNEUROD1;CRELD2;COL1A2;UTP3;NLRP1;ZFPM2A;SORBS2;CCKBR;GH1
protein kinase activityMAP2K2B;MAP3K4;GRK1B;PLK1;Aatk;PINK1;CAMK2D2;DCLK2;EPHA4B
protein serine/threonine kinase activityMAST2;CAMK2D2;GRK7A;MAP3K13;NEK9;STK24;RPS6KAL;ULK3;AAK1

MAP4K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K3.

PRKCQ; Prkcq; LCP2; GRB2; N/A; NCK1; PCBP1; SH3RF1; COPS5

Research Area

Related articles

Hammond, DE; Hyde, R; et al. Quantitative Analysis of HGF and EGF-Dependent Phosphotyrosine Signaling Networks. JOURNAL OF PROTEOME RESEARCH 9:2734-2742(2010).
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