MAPK10 Protein


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Official Full Name mitogen-activated protein kinase 10
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK10-1044H Recombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged E.coli GST
    Human MAPK10-154H Recombinant Human MAPK10 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK10-239H Recombinant Human MAPK10 protein, His-tagged E.coli His
    Human MAPK10-27604TH Recombinant Human MAPK10 E.coli N/A
    Human MAPK10-27605TH Recombinant Human MAPK10 N/A
    Human MAPK10-339H Recombinant Human MAPK10, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK10-691H Recombinant Human Mitogen-activated Protein Kinase 10, GST-His S.frugiperda His/GST
    Human MAPK10-752H Recombinant Human Mitogen-activated Protein Kinase 10 E.coli N/A
    Rhesus Macaque MAPK10-2671R Recombinant Rhesus monkey MAPK10 Protein, His-tagged Mammalian Cell His
    Zebrafish MAPK10-3593Z Recombinant Zebrafish MAPK10 Mammalian Cell His
    Human MAPK10-4497HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4498HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4499HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-01H Recombinant Human MAPK10 protein, His-tagged Insect Cell His
    Human MAPK10-2784H Recombinant Human MAPK10 protein, His-tagged E.coli His
    Human MAPK10-8439HF Recombinant Full Length Human MAPK10 Protein, GST-tagged E.coli GST
    Human MAPK10-3584H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK10-4539H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Mapk10-3938M Recombinant Mouse Mapk10 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway TGFBR1; FGF13A; FOS; MEF2CA; MAP2K5; CACNG2A; MAPK8A; FGFR4; ARR3A; FGF21
    ErbB signaling pathway PRKCA; PLCG1; TGFA; CDKN1BA; CAMK2D; PIK3CA; ARAF; NRG1; PIK3R1; ERBB4
    Ras signaling pathway RAC2; REL; FGF12; BCL2L1; IKBKG; PLA1A; GRB2; MET; PLD1; PLA2G2D
    cAMP signaling pathway CALML3; PPP1R12A; PPP1CC; FSHB; VAV2; MAPK9; PPP1CA; RAC3; NPR1; GLP1R
    FoxO signaling pathway BNIP3; CAT; RAF1A; TGFB1A; SOS1; GRB2; IL6; CCND2A; FOXO3A; HOMER1
    Sphingolipid signaling pathway S1PR5; ROCK1; MAPK9; MAPK12; GNAQ; FCER1G; PPP2R2C; PTEN; KRAS; PRKCZ
    Protein processing in endoplasmic reticulum BCL2; CUL1; ATXN3L; CALR; STT3A; SEC24B; YOD1; ATF4B1; HSPA2; DNAJB1B
    Wnt signaling pathway LEF1; FZD6; NLK2; PRKACA; MAPK8A; CHD8; CER1; FZD9; WNT11B; DVL1B
    Osteoclast differentiation IL1R1; TNF; AKT2; PPP3CA; MAP2K6; LILRB3; LILRB2; TNFRSF11A; AKT1; TRAF6
    Focal adhesion VEGFC; PTK6; PDGFC; CAPN2A; ROCK2B; AKT2L; Itga10&Itgb1; MAPK3; SPP1; HRASA
    Toll-like receptor signaling pathway IKBKB; MAP2K2A; TRAF6; RELA; AKT3A; SPP1; PIK3CB; TRAF3; TLR5; IL-8
    NOD-like receptor signaling pathway IL8L1; MAPK11; SUGT1; PSTPIP1; MAPK9; CXCL1; IL8L2; NAIP6; TRIP6; TNF
    RIG-I-like receptor signaling pathway NLRX1; IFNW1; IKBKG; TBKBP1; Ifna15; IFNA17; MAPK10; TRAF2; IL12B; CXCL10
    Fc epsilon RI signaling pathway PLA2G4F; RAC1; PLCG1; PIK3R5; IL3; MAPK1; PRKCA; MAPK12; GM-CSF; PLCG2
    TNF signaling pathway PIK3R3; FADD; CXCL5; MAPK8; DNM1L; BAG4; CREB3L1; TRAF5; MAPK3; MAPK1
    Neurotrophin signaling pathway PTPN11; NGF; MAP3K1; NTRK1; FOXO3; CALM4; HRAS; MAPK10; GAB1; AKT2
    Retrograde endocannabinoid signaling MAPK3; PRKACB; PTGS2; GRM5; GABRR2; GNG3; GNAI3; GRIA2; PRKACG; GABRA2
    Dopaminergic synapse PRKACG; GNB3; GNG8; DDC; GNAS; KCNJ9; GNAI1; CAMK2A; SLC6A3; CREB5
    Inflammatory mediator regulation of TRP channels PRKCH; ASIC5; HTR2A; ACCN3; MAPK12; PIK3CB; SRC; PRKCD; HRH1; TRPV3
    Insulin signaling pathway RAPGEF1B; AKT3A; MAPK1; PCK1; MAPK10; PCK2; PRKAR1B; TSC1; ARAF; FOXO1
    GnRH signaling pathway GRB2B; CACNA1DA; PLA2G4F; HRAS; MAP3K4; CALM4; CALML3; GNRHR2; PLCB4; PLCB2
    Progesterone-mediated oocyte maturation PIK3R3A; ANAPC5; HSP90AA1.2; MAPK8A; CDC25C; AKT2; MAPK1; SPDYA; RAF1; CCNB2
    Prolactin signaling pathway ELF5; STAT5A; PIK3R2; SOCS2; INS2; SOCS1; MAPK3; PIK3CG; ESR1; STAT5B
    Adipocytokine signaling pathway ACSL3B; ACSL5; MAPK8; RXRGB; PRKAG2; G6PC; MAPK10; NFKBIA; G6PC3; NPY
    Type II diabetes mellitus IRS2; INS-IGF2; MAPK1; PKLR; IRS1; MTOR; MAPK8; SOCS4; SLC2A2; PIK3R3
    Non-alcoholic fatty liver disease (NAFLD) UQCR10; FASLG; CEBPA; TNF; PRKAA2; MAPK8; GSK3B; MAPK10; NDUFS3; LEP
    Epithelial cell signaling in Helicobacter pylori infection NOD1; IKBKB; GIT1; ATP6V1D; ATP6V0B; MAPK8; CDC42; SRC; MAPK10; CXCR2
    Shigellosis PFN1; ARPC5L; PFN2; ROCK2; NFKBIB; BTRC; MAPK9; HCLS1; RAC1; ELMO1
    Salmonella infection WASL; KLC2; CXCL1; NLRC4; RAB7; RAC1B; WASLB; ARPC4L; FLNA; MAPK1
    Pertussis MAPK13; IL1A; RHOA; CFL2; MAPK9; CD14; ITGB2; IRF8; PYCARD; Il23a; Il12b
    Chagas disease (American trypanosomiasis) GNAL; Ccl12; TLR4; MAPK10; TGFBR2; PIK3CG; GNAO1; IRAK4; SMAD2; TGFB3
    Toxoplasmosis LY96; HSPA1L; IKBKG; CASP8; MAPK8; IL12A; LDLR; NFKBIA; Toxoplasma Gondii Microneme Protein MIC3; Toxoplasma Gondii Dense Granule Protein 7
    Tuberculosis PLK3; NFYA; IL18; CALM4; AKT1; LBP; IFNGR2; CLEC4M; CALM2; RELA
    Hepatitis C OAS1A; TLR3; GRB2; ARAF; STAT2; LDLR; CLDN7; PIK3CD; PIAS1; MAPK11
    Influenza A MYD88; MAP2K3; IL33; IFNAR1; SLC25A6; IFNG; NXT1; IVNS1ABP; IFNA4; AKT1
    Herpes simplex infection IFNA17; CCL2; GTF2IRD1; MHC1UEA; PPP1CA; UBE2R2; IFNPHI1; NFKBIAA; MHC2DCB; GTF2I
    Epstein-Barr virus infection RB1; TAB2; POLR3GL; HSPA2; TRAF2; EP300; FGR; POLR2A; AKAP8L; POLR2J3
    Pathways in cancer FGF22; WNT1; BCR; BIRC3; RUNX1T1; GNAS; BDKRB1; BIRC8; VEGFB; FADD
    Colorectal cancer RAC3; TRP53; BRAF; MSH6; TGFB3; ARAF; DCC; MAPK1; APC2; RAF1
    Pancreatic cancer IKBKG; TGFB3; TRP53; RALGDS; IKBKB; RALBP1; BCL2L1; MAPK8; RAC1; SMAD2
    Choline metabolism in cancer PIK3CA; SLC22A3; GRB2; PDGFB; Pdgfa&Pdgfb; PIK3R3; SLC22A5; SLC44A2; PPAP2A; DGKZ

    MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase activity ALPK2; MAPK9; MAPK8; MAPK10
    MAP kinase kinase activity LRRK2; SBK3; MAP2K3; MAP2K2A; MAP2K7; MAPKAPK5; PAK3; MAP2K6; MAP3K9; MAP3K20

    MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.

    ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).

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