MAPK10 Protein


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Official Full Name mitogen-activated protein kinase 10
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK10-1044H Recombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged E.coli GST
    Human MAPK10-154H Recombinant Human MAPK10 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK10-239H Recombinant Human MAPK10 protein, His-tagged E.coli His
    Human MAPK10-27604TH Recombinant Human MAPK10 E.coli N/A
    Human MAPK10-27605TH Recombinant Human MAPK10 N/A
    Human MAPK10-339H Recombinant Human MAPK10, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK10-691H Recombinant Human Mitogen-activated Protein Kinase 10, GST-His S.frugiperda His/GST
    Human MAPK10-752H Recombinant Human Mitogen-activated Protein Kinase 10 E.coli N/A
    Rhesus Macaque MAPK10-2671R Recombinant Rhesus monkey MAPK10 Protein, His-tagged Mammalian Cell His
    Zebrafish MAPK10-3593Z Recombinant Zebrafish MAPK10 Mammalian Cell His
    Human MAPK10-4497HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4498HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4499HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-01H Recombinant Human MAPK10 protein, His-tagged Insect Cell His
    Human MAPK10-2784H Recombinant Human MAPK10 protein, His-tagged E.coli His
    Human MAPK10-8439HF Recombinant Full Length Human MAPK10 Protein, GST-tagged E.coli GST
    Human MAPK10-3584H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK10-4539H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Mapk10-3938M Recombinant Mouse Mapk10 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway NTRK2; PRKCG; FGFR3; RASA1; DUSP16; ELK4; RAF1A; PDGFAB; GADD45AA; MAP2K2B
    ErbB signaling pathway MAP2K4; ERBB3B; MYCB; EGFRA; AKT2; GAB1; RPS6KB1; STAT5A; NCK2B; AREG
    Ras signaling pathway AKT2; RAC1; NGFR; RHOA; IKBKG; FLT1; PAK6; FGFR4; Fgf15; VEGFB
    cAMP signaling pathway ATP1B1; OXTR; RAP1A; NPY1R; ACOX3; PPARA; GABBR2; HTR1F; GRIN2B; ATP1B4
    FoxO signaling pathway PRMT1; PIK3R3; PIK3CB; GADD45BB; PIK3CA; AGAP2; MAP2K1; FOXG1; AKT3A; INSRB
    Sphingolipid signaling pathway TRAF2; MAPK3; GNA12; DEGS2; PLD1; CERS5; PLCB3; NOS3; PIK3CB; SGMS1
    Protein processing in endoplasmic reticulum SEC31B; CAPN1B; SEC61A1; HSC70; FBXO2; MAPK8; MAN1A; MAPK8A; DERL1; DAD1
    Wnt signaling pathway CTBP2A; PPARDB; PRKACA; FZD3A; CAMK2B; NLK2; WNT5A; VANGL2; PPP3R1; FZD3B
    Osteoclast differentiation IL1B; LILRA4; TAB2; FOS; IL1A; MITF; LILRA3; TGFBR1; CYBB; SOCS3
    Focal adhesion PIK3CD; RAF1B; CAPN2L; Itga10&Itgb1; PAK7; CCND1; PTK2; FYNA; VCLA; RAF1A
    Toll-like receptor signaling pathway CASP8; TRAF6; IFNA8; MAP2K2B; CCL3L1; IRF3; IFNA16; STAT1; LY96; CD14
    NOD-like receptor signaling pathway IKBKG; HSP90AA1.1; IL8L1; IL8L2; MAPK8A; MAPK1; MAP3K7IP3; NFKBIAA; MAPK14A; BIRC3
    RIG-I-like receptor signaling pathway TP-1; IKBKE; Ifna15; IFNB1; MAPK8; TANK; PIN1; IFNA10; TBKBP1; NFKBIAB
    Fc epsilon RI signaling pathway IL5; FCER1G; PLA2G4C; FYN; BTK; PLCG2; RAC1; MAPK9; MAP2K6; PIK3R2
    TNF signaling pathway VEGFC; PIK3R3; TRADD; CCL5; TNFAIP3; TNFRSF1B; MAPK11; LTA; MAP2K6; TRAF5
    Neurotrophin signaling pathway NTF4; IRAK1; PIK3CD; FOXO3; BCL2; MAP2K5; IRAK4; NFKBIB; PRKCD; NTRK2
    Retrograde endocannabinoid signaling GABRE; MAPK9; PLCB4; GNAO1; GNB2; PLCB2; MAPK10; GNG10; GNGT1; NAPEPLD
    Dopaminergic synapse CREB3L1; PPP2R1B; PPP3CB; COMT; PRKCB; CAMK2B; GNAO1; PLCB2; ITPR1; AKT2
    Inflammatory mediator regulation of TRP channels PLCB1; PRKACB; PIK3CD; PLA2G4C; PTGER2; IL1B; PRKCE; PLA2G4D; PIK3CG; MAPK13
    Insulin signaling pathway CBL; GSK3AA; PHKG1; PRKCZ; HRAS; SOCS2; RAF1B; TSC1; PPP1CB; AKT2L
    GnRH signaling pathway CAMK2B; CALM4; GNA11A; PRKCB; PLA2G4AA; HRASA; RAF1A; CAMK2D; LHB; ITPR3
    Progesterone-mediated oocyte maturation AKT1; SPDYA; MAPK9; MOS; AKT2L; INS2; IGF1RA; IGF1; RAF1A; PIK3R3A
    Prolactin signaling pathway PIK3R1; INS2; PRL; SHC3; SOCS4; SOCS3; FOS; STAT5A; SIRPA; ESR1
    Adipocytokine signaling pathway PRKAG1; STAT3; MAPK8A; LEP; LEPR; RELA; CPT1C; IRS1; NFKBIAB; NPY
    Type II diabetes mellitus MAPK9; PIK3CA; PIK3R3; IRS4; PIK3R2; PKM; ADIPOQ; SOCS3; INSR; INS
    Insulin resistance PRKAG2A; PYGB; PRKCB; SLC27A2; MTOR; INSRA; PPP1R3CA; MAPK8A; G6PC2; PRKCZ
    Non-alcoholic fatty liver disease (NAFLD) CYCS; COX7A1; NDUFB6; TRAF2; MAP3K5; PRKAB2; NFKB1; NDUFB9; GSK3B; PRKAG2
    Epithelial cell signaling in Helicobacter pylori infection CCL5; NOD1; MAPK9; NFKB1; GIT1; ATP6V0E1; IKBKG; ATP6V1H; ATP6V1D; ATP6V1E2
    Shigellosis VCL; ARPC5L; PFN2; PFN3; BTRC; CDC42; MAPK8; IKBKG; CTTN; MAPK10
    Salmonella infection RILP; ROCK1; FLNA; ACTG1; PKN1; CASPA; IFNG1-2; IL1A; CCL3L3; CCL4L1
    Pertussis MYD88; IL23; C2; CALML3; RELA; MAPK3; CALM4; CALML5; ITGA5; C4A
    Chagas disease (American trypanosomiasis) IKBKB; MAPK1; PPP2R2C; PLCB1; TGFB2; TLR6; PIK3CG; IL-8; FOS; PPP2R2D
    Toxoplasmosis MAPK8; GNAI1; TYK2; HLA-DOA; MAPK9; PIK3CA; NFKB1; IRGM; BCL2; NOS2
    Tuberculosis ATP6V0D2; IRAK4; PPP3R1; IFNA16; BAX; CALML5; ITGAX; TLR2; Il23a; Il12b; HLA-DOB
    Hepatitis C OCLN; IKBKB; Ifna11; IL-8; EIF2AK3; BAD; PPP2R2B; PIK3CB; OSTN; CLDN4
    Hepatitis B MAPK1; PIK3CG; BAD; CASP12; TP53; IFIH1; DDX58; TRP53; PIK3R3; TNF
    Influenza A AKT2; KPNA2; CYCS; NFKB1; Fasl; PIK3R2; PIK3R5; MAPK13; MAPK11; H2-AB1
    Herpes simplex infection CUL1A; IFNA13; SRSF5; PER1A; CLOCK; CD74; MAPK8A; PVRL1; HLA-DOB; CUL1
    Epstein-Barr virus infection PSMD4; POLR3G; HSPA8; HLA-C; RIPK1; TRAF1; POLR2B; TRAF6; TRAF3; HSPB2
    Pathways in cancer GNG5; TRP53; CXCL12; MECOM; WNT1; KITLG; FGF6; DAPK1; APC2; TRAF6
    Colorectal cancer Casp3; ARAF; BAD; BAX; PIK3R5; TGFB2; AXIN2; SMAD2; MAP2K1; MAPK10
    Pancreatic cancer AKT2; RALBP1; RALGDS; CCND1; CDC42; TGFB3; TGFA; TGFB2; RAF1; SMAD4
    Choline metabolism in cancer PDGFA; PRKCA; MAPK3; SLC44A1; KRAS; PLA2G4A; RAC3; WASF2; WASL; PIK3R3

    MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding SRPK1; NETO2; NEK3; STK17B; RAF1B; ATP9B; MCM2; ERBB3A; MAP2K4B; NEK10
    JUN kinase activity MAPK9; MAPK10; ALPK2; MAPK8
    MAP kinase kinase activity LRRK2; MAPK14; MAP2K7; MAP2K3; MAP2K1; MAPKAPK5; MAP3K14; MAPK10; MAP3K20; MAP2K2B
    protein binding CARD11; UBE2B; SUGP1; PARVA; CALR; BRPF3; PLEKHF2; CALM3; VSTM2L; HIST1H2AK

    MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.

    ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).

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