• Official Full Name

    mitogen-activated protein kinase 10

  • Background

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms

    MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • His|GST
    • His|MBP
    • Myc
    • DDK
    • N/A
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK10-27604TH Recombinant Human MAPK10 E.coli N/A
    Human MAPK10-239H Recombinant Human MAPK10 protein, His-tagged E.coli His
    Human MAPK10-339H Recombinant Human MAPK10, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK10-4499HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-27605TH Recombinant Human MAPK10 N/A
    Human MAPK10-3584H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK10-691H Recombinant Human Mitogen-activated Protein Kinase 10, GST-His S.frugiperda His/GST
    Human MAPK10-752H Recombinant Human Mitogen-activated Protein Kinase 10 E.coli N/A
    Human MAPK10-4497HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-1044H Recombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged E.coli GST
    Human MAPK10-4539H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK10-154H Recombinant Human MAPK10 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK10-4498HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-2784H Recombinant Human MAPK10 protein, His-tagged E.coli His
    Human MAPK10-1140H Recombinant Human MAPK10 Protein (M1-S423), Tag Free E.coli No tag
    Human MAPK10-1141H Recombinant Human MAPK10 Protein (M1-S423), His tagged E.coli His
    Human MAPK10-01H Recombinant Human MAPK10 protein, His-tagged Insect Cell His
    Mouse Mapk10-3938M Recombinant Mouse Mapk10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque MAPK10-2491R-B Recombinant Rhesus Macaque MAPK10 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque MAPK10-2491R Recombinant Rhesus Macaque MAPK10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque MAPK10-2671R Recombinant Rhesus monkey MAPK10 Protein, His-tagged Mammalian Cell His
    Zebrafish MAPK10-3593Z Recombinant Zebrafish MAPK10 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • MAPK10 Related Articles
    • MAPK10 Related Research Area
    • MAPK10 Related Signal Pathway

    MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathwayMAP3K1;MAP2K1;FAS;FGF13A;NLK1;TMEM37;MKNK2A;FGF19;CDC42
    ErbB signaling pathwayPAK3;SHC4;NRG2B;PIK3CB;ERBB4A;GRB2B;CDKN1BA;STAT5B;ELK1
    Ras signaling pathwayBAD;GNG7;RAC1;KRAS;FGF20;MAPK10;FGF8;KITLG;BRAP
    cAMP signaling pathwayGNAS;PLD2;PIK3R2;GPR119;NFKBIA;ATP1B4;PDE3B;GNAI1;HCN4
    FoxO signaling pathwayPDPK1;PRKAG3;SGK2A;HRASA;FOXO3A;STK4;SGK2;TGFBR1B;AKT2
    Sphingolipid signaling pathwayMAPK1;RAF1;GNA12;TRP53;PRKCG;PPP2R3C;SGMS2;SPTLC3;MS4A2
    Protein processing in endoplasmic reticulumEDEM3;CALRL2;SEC61A1;TXNDC5;BAG2;CAPN2A;UBE2D4;UBQLN2;TRAF2
    Wnt signaling pathwayCCND2;PLCB3;MAPK10;WNT6;NFATC2;RHOAC;CAMK2A;MAPK8B;MAP3K7
    Osteoclast differentiationPLCG2;GRB2;FCGR2B;TRAF6;PIK3R2;MITF;LILRA2;LILRB1;LILRA3
    Toll-like receptor signaling pathwayIRAK4;FOS;IL12BA;CCL4;PIK3CB;MAPK9;MYD88;TLR4BA;IL12A
    NOD-like receptor signaling pathwayNAIP1;MAPK1;HSP90AA1.2;TNFAIP3;ERBB2IP;NFKB1;PSTPIP1B;IKBKG;IL1B
    RIG-I-like receptor signaling pathwayDDX3;IFNA1;CXCL10;MAPK8B;IL-8;IFNPHI1;IKBKG;NFKBIA;IFNA14
    Fc epsilon RI signaling pathwayGM-CSF;GAB2;SYK;RAC2;PIK3R2;PRKCA;PIK3R3;BTK;PIK3CD
    TNF signaling pathwayCASP8;MMP14;FADD;RPS6KA4;CASP10;CCL20;PIK3R1;PIK3CA;ITCH
    Neurotrophin signaling pathwayPRDM4;PSEN1;FASLG;NFKB1;CALML3;TP53;ATF4;PRKCD;CALM3
    Retrograde endocannabinoid signalingGNG13;GNB4;GNG3;GABRB3;MAPK12;GNAI1;GABRD;GNB2;PRKCA
    Dopaminergic synapseGNGT1;GRIA2;CALML3;DRD1;PPP2R3A;KCNJ9;KIF5C;PPP3CA;PPP1CA
    Inflammatory mediator regulation of TRP channelsPRKCQ;NTRK1;PPP1CA;ALOX12E;CYP4A12A;PRKCE;P2RY2;ASIC3;CALM3
    Insulin signaling pathwayMTOR;MAPK1;PPP1CB;AKT3A;GYS1;AKT1;AKT2;PRKAG3B;PHKG1
    Progesterone-mediated oocyte maturationCCNA1;HSP90AB1;ANAPC2;CDC27;AKT2;CDC25A;MAPK8A;CDC25B;CCNA2
    Prolactin signaling pathwayFOXO3;LHB;RAF1;SOCS2;ESR2;PIK3R2;PIK3CG;GSK3B;SRC
    Adipocytokine signaling pathwayLEPA;G6PC;G6PC2;PRKAA1;PRKAG1;SOCS3;MAPK10;PRKAG2A;RXRG
    Insulin resistanceGYS2;CREB3L1;SLC27A3;RPS6KA2;GSK3AA;PRKCZ;PYGB;PTPN11B;PIK3R1
    Non-alcoholic fatty liver disease (NAFLD)CEBPA;NDUFS2;Casp3;NDUFA12;NDUFB10;MAPK9;PRKAG3;UQCRC1;RAC1
    Epithelial cell signaling in Helicobacter pylori infectionSRC;PTPN11;PAK1;RELA;MET;ATP6V0B;ATP6V1A;RAC1;ATP6V1C2
    Salmonella infectionPFN3;MAPK12;KLC1B;ROCK2B;CXCL1;TLR4;CDC42L;CXCL8B.3;CCL3L3
    Chagas disease (American trypanosomiasis)FADD;MYD88;MAPK12;PPP2CA;GNA14;SMAD3;TLR4;PIK3CB;Fasl
    Herpes simplex infectionSRSF7A;HCFC1;PER1B;C3A.3;PTPN11A;NFKBIB;TAP1;HLA-B;FASLG
    Epstein-Barr virus infectionPOLR2J3;BCL2;HSPA1B;EIF2AK4;POLR3K;EIF2AK3;TNFAIP3;FCER2;HLA-DPB1
    Pathways in cancerWNT5B;SUFU;FGF8;FH;ITGA2;ERBB2;IKBKB;GLI1;RASSF5
    Colorectal cancerBRAF;Casp3;PIK3R5;MSH6;PIK3R1;PIK3R2;SMAD4;MAPK9;TGFB3
    Pancreatic cancerTP53;PLD1;RB1;MAPK3;RALBP1;STAT1;IKBKG;TGFB3;MAPK1
    Choline metabolism in cancerPIK3R2;SLC22A5;PLD1;LYPLA1;DGKA;PDGFA;FOS;MAPK3;SLC5A7

    MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase activityMAPK9;ALPK2;MAPK8;MAPK10
    MAP kinase kinase activityMAP2K2;MAP3K20;LRRK2;MAP2K2B;MAP2K7;MAPK14;MAP2K3;MAP3K9;ALPK2
    protein bindingNFIL3;KRTAP12-4;PPFIA4;TRMT2B;RPF1;TMEM64;TUBB;DDX23;GAD1

    MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.

    ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).
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