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Official Full Name mitogen-activated protein kinase 10
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK10-1044H Recombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged E.coli GST
    Human MAPK10-154H Recombinant Human MAPK10 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK10-239H Recombinant Human MAPK10 protein, His-tagged E.coli His
    Human MAPK10-27604TH Recombinant Human MAPK10 E.coli N/A
    Human MAPK10-27605TH Recombinant Human MAPK10 N/A
    Human MAPK10-339H Recombinant Human MAPK10, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK10-3584H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK10-4497HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4498HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4499HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4539H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK10-691H Recombinant Human Mitogen-activated Protein Kinase 10, GST-His S.frugiperda His/GST
    Human MAPK10-752H Recombinant Human Mitogen-activated Protein Kinase 10 E.coli N/A
    Mouse Mapk10-3938M Recombinant Mouse Mapk10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque MAPK10-2671R Recombinant Rhesus monkey MAPK10 Protein, His-tagged Mammalian Cell His
    Zebrafish MAPK10-3593Z Recombinant Zebrafish MAPK10 Mammalian Cell His

    mapk10 involved in several pathways and played different roles in them. We selected most pathways mapk10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with mapk10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF19; FGF17; NTRK2B; MAP2K2; MAPK14B; MAP2K2A; FGF1A; MAP2K5; NFATC3; RRAS
    ErbB signaling pathway RPS6KB1; MAPK1; EREG; HRASB; PAK2; MAP2K4B; RAF1A; CAMK2G1; KRAS; NCK2A
    Ras signaling pathway IKBKB; Fasl; GNG2; PLA2G2D; RASGRF2; NGF; PLCG2; MAPK9; FGF6; ANGPT1
    cAMP signaling pathway BAD; VAV1; PLD2; CALM2; PRKACG; VAV2; CNGA3; TNNI3; GRIN2C; HCAR3
    FoxO signaling pathway FOXG1; PCK2; BNIP3; FOXO4; GRB2; GABARAPA; BCL6; SGK3; BCL6A; PRKAA2
    Sphingolipid signaling pathway SMPD2; ACER1; PPP2R5E; RAC3; FCER1G; MAPK1; PIK3R3; PRKCZ; PLD1; MAP2K1
    Protein processing in endoplasmic reticulum EIF2S1B; VIMP; DAD1; DNAJC1; NFE2L2A; EIF2AK4; TRAM1; CUL1; LMAN2; PDIA6
    Wnt signaling pathway TCF7L1A; WNT7A; LRP5; FBXW11; PRKACA; EP300; PLCB3; FZD3B; WNT7B; FBXW2
    Osteoclast differentiation MAPK3; TGFB2; MAPK8; SIRPB1; SPI1; NFATC2; LILRB5; PIK3R2; FCGR3B; TGFBR2
    Focal adhesion MYLK2; RAC1B; MYL9; MAPK9; ITGB3; LAMA2; LAMC2; PIP5K1C; THBS4; ARHGAP5
    Toll-like receptor signaling pathway MAPK12; IRAK4; MAPK8; IFNA16; MAPK13; MAP2K4; MAPK14A; LBP; MAP3K7; IFNB1
    NOD-like receptor signaling pathway IL6; CXCL2; NFKBIB; TRAF6; TAB3; IL8L1; MAPK11; MAPK1; TNFAIP3; HSP90AB1
    RIG-I-like receptor signaling pathway IL12B; MAPK12; TRADD; MAPK12B; IFNA3; TRAF2; IFNA14; TRIM25; IFNA7; NFKBIB
    Fc epsilon RI signaling pathway LYN; VAV2; FCER1G; MAPK12; PIK3R1; PIK3R2; PLA2G4D; LAT; FCER1A; RAC1
    TNF signaling pathway MAPK11; BAG4; TAB2; MAP2K4; VCAM1; TRAF2; MAGI2; LIF; IL15; IL1B
    Neurotrophin signaling pathway IRAK4; NTF3; PIK3R2; PSEN2; SH2B3; SHC4; CALM2; CAMK2G; BRAF; PIK3R5
    Retrograde endocannabinoid signaling GABRR1; MAPK12; GABRA2; GABRD; GRM1; GNG2; GNG12; GABRA3; GNAO1; GNAI2
    Dopaminergic synapse CAMK2D; KIF5C; CALML5; CREB3; PRKCA; PPP1CA; PPP3CB; MAPK9; GNGT2; GNG8
    Inflammatory mediator regulation of TRP channels CAMK2D; ASIC4; TRPV4; PLCG1; PLA2G4A; ITPR1; PIK3R5; GNAS; CALM4; Adcy4
    Insulin signaling pathway PYGM; MAPK8B; FLOT2B; BADB; FLOT1B; AKT3A; RHEB; PRKAA2; GRB2A; PTPRF
    GnRH signaling pathway CGNRH-R; GNA11A; ITPR3; CACNA1C; CDC42L2; MAPK12A; GNAS; GNRHR2; CAMK2D1; PRKCBB
    Progesterone-mediated oocyte maturation AKT3A; PIK3CD; MAD1L1; SPDYB; PIK3CA; RPS6KA2; GNAIA; GNAI3; ADCY1A; FZR1
    Prolactin signaling pathway STAT5A; SOCS7; SOCS5; GALT; RAF1; SOCS6; SOCS2; SIRPA; MAPK13; ESR2
    Adipocytokine signaling pathway ACSL4; ADIPOR1B; JAK2A; ACACB; CD36; TNFRSF1B; G6PCA.1; SLC2A4; NFKBIB; PRKAG2
    Type II diabetes mellitus PIK3R2; MAPK8; INS; PIK3R5; INS2; PRKCE; MAPK3; MAPK10; HK3; SOCS2
    Insulin resistance PRKAG2A; PRKCB; MAPK10; INS1; PIK3R3B; SLC27A4; ACACB; SLC27A1B; SLC2A2; TNFRSF1A
    Non-alcoholic fatty liver disease (NAFLD) ATF4; NDUFA6; IL6; IRS2; MAPK8; COX8C; INS; INS1; PIK3CD; TGFB1
    Epithelial cell signaling in Helicobacter pylori infection NFKB1; PTPN11; ATP6V0D2; ATP6V0A2; IKBKG; ATP6V1G2; SRC; ATP6V0A1; GIT1; CXCL1
    Shigellosis BTRC; PFN2; ABL1; RIPK2; ROCK2; ITGA5; HCLS1; NFKB1; VCL; NFKBIA
    Salmonella infection CDC42; FOS; NOS2B; KLC1A; LBP; CCL3; ARPC5L; ACTB2; IFNGR2; ARPC4L
    Pertussis IL-8; CXCL5; C1QA; CASP7; MAPK10; NOS2; MAPK12; C1RA; FOS; C5
    Chagas disease (American trypanosomiasis) IL1B; IL12B; MAPK11; PPP2CA; SERPINE1; PLCB1; CCL5; PLCB2; IFNB1; TLR9
    Toxoplasmosis Toxoplasma Gondii Microneme Protein MIC3; GNAI1; TGFB3; IRAK1; IRGM1; PIK3CA; PPIF; LAMA3; Toxoplasma Gondii Major Surface Antigen P30; TRAF6
    Tuberculosis ITGB2L; FCGR1; FCGR1A; CALML5; MRC1; FCER1G; HLA-DRB4; PPP3R2; FCGR4; CD74
    Hepatitis C EIF2AK1; GRB2; KRAS; IFNA13; CLDN10; MAPK13; TNF; MAPK12; IL-8; PPP2R2A
    Hepatitis B STAT6; RELA; CASP12; ATF4; IRF7; ATP6AP1; BIRC5; IFNA17; IKBKE; TGFB3
    Herpes simplex infection BLA; CUL1; TNFB; PPP1CC; TRAF1; IFNAR2; PVRL1B; STAT1; TNFRSF14; MAPK8B
    Epstein-Barr virus infection POLR2J; EIF2AK4; PSMD2; NEDD4; TNFAIP3; RELB; Fcer2a; POLR2B; POLR2A; SKP2
    Pathways in cancer VEGFA; FGF12; F2RL3; DAPK3; WNT10B; WNT16; TP53; HRAS; LEF1; GNG5
    Colorectal cancer BCL2; CCND1; APC; BAX; PIK3CB; PIK3CG; ARAF; MAP2K1; MLH1; PIK3R3
    Pancreatic cancer RELA; RB1; RAF1; CDC42; AKT1; PIK3R3; KRAS; TGFBR2; TRP53; STAT3
    Choline metabolism in cancer DGKG; PDGFRA; PIK3R3; PIP5K1B; CHKA; WASF1; SOS1; PIK3CG; PDGFC; PDGFA

    mapk10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by mapk10 itself. We selected most functions mapk10 had, and list some proteins which have the same functions with mapk10. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase activity MAPK8; MAPK10; MAPK9; ALPK2
    MAP kinase kinase activity MAPKAPK5; MAP3K20; ALPK2; MAP3K9; MAP2K6; MAP2K2; MAP2K3; MAP2K2A; PAK3; MAPK10
    protein binding ZNF26; PPP2R2C; EPB49; BCL10; PCDH17; AMIGO2; TACR1; CSNK2A1; BLOC1S6; KRT6A

    mapk10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mapk10 here. Most of them are supplied by our site. Hope this information will be useful for your research of mapk10.

    ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).

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