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Official Full Name mitogen-activated protein kinase 10
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
    • Species :
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK10-1044H Recombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged E.coli GST
    Human MAPK10-154H Recombinant Human MAPK10 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK10-239H Recombinant Human MAPK10 protein, His-tagged E.coli His
    Human MAPK10-27604TH Recombinant Human MAPK10 E.coli N/A
    Human MAPK10-27605TH Recombinant Human MAPK10 N/A
    Human MAPK10-339H Recombinant Human MAPK10, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK10-4497HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4498HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-4499HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
    Human MAPK10-691H Recombinant Human Mitogen-activated Protein Kinase 10, GST-His S.frugiperda His/GST
    Human MAPK10-752H Recombinant Human Mitogen-activated Protein Kinase 10 E.coli N/A
    Rhesus Macaque MAPK10-2671R Recombinant Rhesus monkey MAPK10 Protein, His-tagged Mammalian Cell His
    Zebrafish MAPK10-3593Z Recombinant Zebrafish MAPK10 Mammalian Cell His

    mapk10 involved in several pathways and played different roles in them. We selected most pathways mapk10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with mapk10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway TGFBR1A; MAP3K4; MAPKAPK5; RPS6KA2; STMN1B; CACNB3; DUSP16; CDC42L; MKNK2B; FLNB
    ErbB signaling pathway MAP2K1; NCK2A; PIK3CA; MAP2K4B; PRKCG; AREGB; KRAS; HBEGFB; GSK3B; PTK2AB
    Ras signaling pathway GRB2; RALGDS; RAB5B; PIK3R1; PIK3CB; PDGFD; CDC42; PTPN11; GNG12; BRAP
    cAMP signaling pathway HTR6; VAV2; HCAR2; ROCK2; ATP1B1; GRIA4; PIK3R1; PIK3CD; OXTR; PLCE1
    FoxO signaling pathway PRKAG2A; SETD7; CAT; PIK3R3; GRM1; KLF2A; SMAD2; BCL6; NRAS; FBXO25
    Sphingolipid signaling pathway TNF; PPP2R2C; BDKRB2; SGPL1; MAP3K5; PRKCG; PLCB2; MAPK3; GNAI1; GNA12
    Protein processing in endoplasmic reticulum MAP2K7; EIF2S1B; ERN1; HSPH1; UBQLN1; DNAJC3; SEC62; CCDC102A; SEC24C; ERLEC1
    Wnt signaling pathway SFRP1A; RAC3B; TP53; CAMK2B1; WNT9A; FZD6; WIF1; RAC2; FBXW11B; MAPK8B
    Osteoclast differentiation MAPK9; BLNK; MAP2K1; AKT2; MITF; NCF2; PIK3CG; LILRB5; PPP3CB; STAT1
    Focal adhesion FIGF; LAMB4; VEGFAB; ITGA3; TNW; CAV2; KDR; RAC3; PTK2AB; BIRC2
    Toll-like receptor signaling pathway MAP2K2B; IFNAR1; TLR1LA; IL1B; AKT1; IFNB1; IL12BA; NFKB1; IFNA14; NFKBIAB
    NOD-like receptor signaling pathway NFKBIA; IL8L1; CXCL8B.3; CARD8; MAP3K7; IL1B; LOC100033925; NFKBIAA; TRAF6; SUGT1
    RIG-I-like receptor signaling pathway OTUD5A; ATG5; IFNA14; MAPK12B; IRF7; IFNA12; IFNE; IL12BA; TBKBP1; DAK
    Fc epsilon RI signaling pathway AKT1; VAV2; MAP2K4; MAP2K6; PLA2G4D; RAC2; PDPK1; GRB2; MAPK9; IL4
    TNF signaling pathway Casp3; IL15; CASP7; PIK3CG; NFKBIA; TRAF3; CCL5; MAP3K7IP3; MAPK11; MAP2K6
    Neurotrophin signaling pathway AKT1; SOS1; MAPK11; MAPK8; HRAS; MAP2K2; MAP2K1; CALML3; SH2B3; PTPN11
    Retrograde endocannabinoid signaling GNAO1; PLCB3; MAPK9; GNG2; GNG8; GABRP; GRM1; GNB4; GABRG1; GABRR2
    Dopaminergic synapse CALM1; DRD4; PPP1CB; GRIA3; MAPK9; PLCB1; SLC18A2; PRKCG; PPP3CA; PRKACB
    Inflammatory mediator regulation of TRP channels SRC; PPP1CA; ITPR3; CAMK2B; PPP1CB; ACCN5; PLA2G4F; PRKCH; PIK3R3; PLA2G6
    Insulin signaling pathway SH2B2; PRKACA; PRKAG3B; FLOT2B; CALM2B; GSK3B; EIF4E1C; ELK1; PPP1R3B; SHC4
    GnRH signaling pathway GNRH2; CACNA1D; MAPK9; MAPK3; SOS1; GNRH1; GNRHR; GRB2B; GNRHR2; MAP2K3
    Progesterone-mediated oocyte maturation RPS6KA6; HSP90AB1; CDC16; MAPK8; CCNA2; GNAI2; PRKACG; BUB1; CPEB2; PRKACB
    Prolactin signaling pathway MAPK12; PPIB; SHC2; GALT; MAP2K2; IRF1; MAPK13; STAT5A; CSN2; PIK3CA
    Adipocytokine signaling pathway SLC2A4; RELA; PPARAB; STK11; CHUK; AKT3A; PRKAB2; RXRGB; ACSL3A; NFKB1
    Type II diabetes mellitus PIK3R3; PIK3R1; PIK3CB; HK1; INS1; PRKCZ; SLC2A4; PIK3R2; MTOR; IKBKB
    Insulin resistance SLC2A4; PRKAG3B; PPP1CAB; PRKCBA; RPS6KA3A; NR1H3; PTPN1; G6PC2; ACACB; PTENA
    Non-alcoholic fatty liver disease (NAFLD) PIK3CA; BID; PRKAG2; COX4I2; NDUFA6; TNFRSF1A; INS2; IL1B; Il6ra; PRKAA1
    Epithelial cell signaling in Helicobacter pylori infection ADAM17; JAM3; NFKB1; CXCL1; CCL5; ATP6V1B1; MAP3K14; ATP6V0A4; ATP6V0A1; ATP6V1D
    Shigellosis ACTB; CTTN; CDC42; UBE2D2; CD44; MAD2L2; MAPK11; MAPK9; U2AF1; IL-8
    Salmonella infection NOS2B; RAB7A; PKN1; CXCL2; ARPC5LB; TLR5; TLR4; PKN3; CXCL8B.3; CASP1
    Pertussis MAPK11; CASP1; LY96; SERPING1; C1R; C5; IL12B; CXCL5; ITGB2L; C2
    Chagas disease (American trypanosomiasis) CCL3; TGFB3; IL1B; IRAK4; TLR4; FAS; PPP2R2C; MAPK11; FASLG; PIK3R1
    Toxoplasmosis MYD88; MAPK8; AKT1; IFNG; IL10RA; HLA-DRB3; LAMB1; IRGM1; IRAK1; HLA-DMA
    Tuberculosis HLA-DRA; PPP3CA; IFNA6; MAPK1; TLR1; ATP6V0D2; EP300; ITGB2L; FCGR3; CALM4
    Hepatitis C CLDN14; IFNA13; CLDN23; EIF2AK3; AKT2; IRF7; OSTN; TNFRSF1A; ARAF; IFNA7
    Hepatitis B SMAD4; IFIH1; SRC; RAF1; ELK1; CASP10; IFNA6; AKT2; CXCL8; IFNA21
    Influenza A MAP2K1; SLC25A6; MAPK13; IFNB1; IFNA12; GSK3B; IFNA7; IFNA21; CCL2; ACTB
    Herpes simplex infection TBK1; DAXX; SRSF6; POU2F3; HLA-G; TLR3; IFIT1; IKBKG; C3A.2; HLA-DMA
    Epstein-Barr virus infection HLA-DPA1; PSMD7; HSPA1B; HLA-DRA; IRAK1; PSMD13; PSMD1; IFNG; MAP3K14; EIF2AK3
    Pathways in cancer RXRG; BMP4; FGFR3; STK4; RASSF1; TRAF2; PRKACB; STAT3; AXIN1; LAMB1
    Colorectal cancer PIK3R1; LEF1; MLH1; AKT1; PIK3CA; RALGDS; BAX; TP53; BCL2; TCF7L2
    Pancreatic cancer TRP53; CASP9; ERBB2; TGFBR1; BAD; PIK3R1; TGFB3; RALGDS; BRCA2; RAC1
    Choline metabolism in cancer PLD1; PLA2G4D; PIK3R5; PIK3CA; WASL; SP1; DGKB; RALGDS; PDGFD; LYPLA1

    mapk10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by mapk10 itself. We selected most functions mapk10 had, and list some proteins which have the same functions with mapk10. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase activity ALPK2; MAPK10; MAPK9; MAPK8
    MAP kinase kinase activity MAP3K20; MAP2K2; MAP2K7; SBK3; PAK3; MAP2K2A; LRRK2; MAP2K2B; MAP2K3; MAP2K1
    protein binding LBH; RING1; NFKB2; GHITM; DNTT; BUD13; ABI1; VEGFAB; NKX3-1; TTC5

    mapk10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mapk10 here. Most of them are supplied by our site. Hope this information will be useful for your research of mapk10.

    ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).

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