MAPK10
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Official Full Name
mitogen-activated protein kinase 10
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Overview
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;
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- MAPK10 Related Signal Pathway
MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | CDC42;RRAS2;SOS1;RPS6KA5;IL1R1;GADD45BB;PTPN7;Pdgfa&Pdgfb;CACNB3A |
| ErbB signaling pathway | AREG;PIK3R2;CDKN1BA;MAPK8B;CDKN1BB;GSK3AA;MAP2K4B;STAT5A;RPS6KB1B |
| Ras signaling pathway | RASA3;FGF5;MAP2K1;GAB2;PLA2G4A;RRAS;GNG13;RRAS2;PLA2G12B |
| cAMP signaling pathway | GRIN2D;PPARA;MAP2K2;Adcy4;PIK3R5;MAPK9;MC2R;PIK3CB;PIK3R3 |
| FoxO signaling pathway | PIK3CA;BNIP4;TGFBR1B;AKT3A;PRKAB1;GADD45B;MAPK8A;IL7R;PIK3CD |
| Sphingolipid signaling pathway | SPTLC2;AKT2;PPP2CB;MS4A2;CERS5;SGPP1;PPP2R2D;MAPK3;ROCK1 |
| Protein processing in endoplasmic reticulum | PDIA4;UBE2J1;CAPN1B;DNAJC5AA;PDIP5;UBE4B;UBE2D1B;CANX;STT3A |
| Wnt signaling pathway | DKK2;FBXW11B;FZD3A;WNT5B;FZD2;FOSL1;PRKACAA;WNT4;NLK1 |
| Osteoclast differentiation | FCGR2A;FOSB;MAP2K1;TNF;SOCS1;FCGR3;OSCAR;SIRP-BETA;LILRB4 |
| Focal adhesion | HGF;CAPN2B;Reln;VTNB;THBS4B;PTK2;BCAR1;CCND3;CCND2 |
| Toll-like receptor signaling pathway | TMED7-TICAM2;MAPK10;IKBKB;MAPK1;TLR8;FOS;IL-8;PIK3R2;PIK3CD |
| NOD-like receptor signaling pathway | PYDC1;MAP3K7;ERBB2IP;NFKBIAA;CCL2;MAPK14A;NAIP1;NLRP1;IKBKG |
| RIG-I-like receptor signaling pathway | RIPK1L;IFNA3;IFNA12;MAPK13;IKBKB;MAPK14B;RNF207B;TNF;ATG12 |
| Fc epsilon RI signaling pathway | PLA2G4A;PDPK1;MAP2K1;PIK3CG;MAPK9;HRAS;PLCG2;MAPK3;PIK3R2 |
| TNF signaling pathway | PIK3R3;AKT2;BIRC2;DNM1L;BCL3;MAPK8;TRAF5;SOCS3;CXCL3 |
| Neurotrophin signaling pathway | PIK3CB;GAB1;ATF4;PDPK1;MAP2K5;RIPK2;SH2B3;NTRK2;PLCG2 |
| Retrograde endocannabinoid signaling | PLCB1;DAGLB;PTGS2;GNG5;GABRB3;ABHD6;PRKACA;PRKCB;MAPK13 |
| Dopaminergic synapse | CREB3L2;AKT1;PRKACG;KIF5C;ARRB2;PPP2CB;KIF5A;GNB2;MAPK12 |
| Inflammatory mediator regulation of TRP channels | TRPV4;SRC;PLCG1;TRPM8;PRKACA;PRKCG;BDKRB2;MAPK11;PPP1CB |
| Insulin signaling pathway | AKT3A;CALM1;CALM2;MAPK8A;EIF4E2RS1;FLOT2B;RAF1B;CBL;SOCS9 |
| GnRH signaling pathway | CDC42;MAPK13;CAMK2D;MAPK1;ATF4;MMP14B;ELK1;CALM4;PRKCBB |
| Progesterone-mediated oocyte maturation | MAPK11;CDC16;PIK3R1;MAPK12;ANAPC4;CCNB3;MAPK14A;PIK3R5;AKT2L |
| Prolactin signaling pathway | PRL;INS2;NRAS;STAT5B;ESR2;MAPK3;SOCS4;TNFRSF11A;SLC2A2 |
| Adipocytokine signaling pathway | CPT1B;G6PC2;ACSL1B;JAK2B;RXRAA;JAK2;MAPK8A;CAMKK1;PCK1 |
| Type II diabetes mellitus | PIK3CB;PIK3R5;PIK3CG;INS1;PIK3R3;MAPK10;PIK3CA;PKM2;MAPK9 |
| Insulin resistance | NR1H2;PYGL;PYGB;RPS6KAL;PRKAB2;PRKCBB;PPP1R3A;PRKAA2;PTPN11A |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFA1;Fasl;COX4I2;UQCRQ;INS1;ADIPOR1;NDUFB11;NDUFB6;FASLG |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V0D1;ATP6V1B1;MAPK10;ATP6V0C;IKBKB;ATP6V1D;NFKB1;F11R;ATP6V1E1 |
| Shigellosis | CD44;PFN3;CDC42;MAPK11;RIPK2;ATG5;WASL;DIAPH1;MAPK10 |
| Salmonella infection | PKN1;ACTB;RAC1;WASLA;PFN4;PLEKHM2;CCL3L1;ROCK2A;ROCK1 |
| Pertussis | IRF1;C1R;CALML3;IL12B;IL12A;CXCL6;CD14;NLRP3;CFL2 |
| Chagas disease (American trypanosomiasis) | TGFB2;IKBKG;AKT2;CXCL8;IL10;TGFB1;SERPINE1;PPP2CB;GNA14 |
| Toxoplasmosis | LAMA1;TLR2;HLA-DRA;Casp3;LAMC2;GNAI2;LAMB4;STAT3;IKBKB |
| Tuberculosis | IL1A;FCGR3;EP300;FCGR1A;TLR2;PPP3CA;RHOA;ITGAX;IFNB1 |
| Hepatitis C | MAPK12;TNFRSF1A;PPARA;PDPK1;KRAS;PPP2R1A;IL-8;EIF2AK2;TNF |
| Hepatitis B | TBK1;ATF4;FADD;Ifna11;ATP6AP1;OSTN;NFATC4;TP53;IFNA13 |
| Influenza A | NXF2;ICAM1;HLA-DQB1;PIK3R3;IFIH1;PIK3CD;FURIN;HSPA8;CPSF4 |
| Herpes simplex infection | TBPL1;Ifna11;HLA-DQA1;TAB2;SOCS3B;TLR2-1;SRPK1;PPP1CBL;BF1 |
| Epstein-Barr virus infection | EIF2AK2;PSMD3;NFKBIA;YWHAG;CD44;STAT3;PIK3R3;FGR;MAP3K7 |
| Pathways in cancer | PTGER1;EGLN2;MLH1;SPI1;RASSF1;FAS;NKX3-1;TGFB3;DAPK2 |
| Colorectal cancer | MAPK8;ARAF;BRAF;TGFB1;PIK3CB;MSH3;CYCS;AKT1;PIK3CA |
| Pancreatic cancer | PIK3R1;PIK3CD;TGFB3;ARHGEF6;BAD;RALBP1;MAPK8;PLD1;PIK3CG |
| Choline metabolism in cancer | PIP5K1B;DGKG;PLD1;PLA2G4A;PIK3CB;GPCPD1;TAE1;PIP5K1A;SP1 |
MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | GK5;DDX39;RUNX2;CHD7;NLRP3;MYH1E;GMPS;DSTYK;ABCB3L1 |
| JUN kinase activity | MAPK10;MAPK9;MAPK8;ALPK2 |
| MAP kinase kinase activity | MAPK14;MAP2K2A;MAP2K7;MAP3K20;PAK3;MAP2K2;MAP2K2B;MAP3K9;ALPK2 |
| protein binding | PRKAR2A;RAD51B;BRE;RNF34;FLAD1;EOMESA;PARP2;MEIS1;COL6A2 |
MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.
ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62
Research Area
Related articles
Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).
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