MAPK10

  • Official Full Name

    mitogen-activated protein kinase 10

  • Overview

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Synonyms

    MAPK10; mitogen-activated protein kinase 10; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK; MAPK 10; MAP kinase 10; MAP kinase p49 3F12; JNK3 alpha protein kinase; c-Jun N-terminal kinase 3; stress-activated protein kinase 1b; stress activated protein kinase beta; stress-activated protein kinase JNK3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • S.frugiperda
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK10-86HFL Active Recombinant Full Length Human MAPK10 Protein, N-His-tagged Sf21 His Full Length
Human MAPK10-87HFL Unactive Recombinant Full Length Human MAPK10 Protein, N-His-tagged Sf21 His Full Length
Human MAPK10-239H Recombinant Human MAPK10 protein, His-tagged E.coli His
Human MAPK10-339H Recombinant Human MAPK10, GST-tagged, Active Sf9 Insect Cell GST
Human MAPK10-752H Recombinant Human Mitogen-activated Protein Kinase 10 E.coli N/A
Human MAPK10-27604TH Recombinant Human MAPK10 E.coli N/A
Human MAPK10-1044H Recombinant Human Mitogen-Activated Protein Kinase 10, GST-tagged E.coli GST
Human MAPK10-691H Recombinant Human Mitogen-activated Protein Kinase 10, GST-His S.frugiperda His/GST
Human MAPK10-154H Recombinant Human MAPK10 protein, His/MBP-tagged E.coli His/MBP 21-110 aa
Human MAPK10-27605TH Recombinant Human MAPK10 N/A
Human MAPK10-4499HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
Human MAPK10-4497HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
Human MAPK10-4498HCL Recombinant Human MAPK10 293 Cell Lysate HEK293 N/A
Human MAPK10-3584H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK10-4539H Recombinant Human MAPK10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK10-2784H Recombinant Human MAPK10 protein, His-tagged E.coli His 271-408 aa
Human MAPK10-01H Recombinant Human MAPK10 protein, His-tagged Insect Cell His 1-464aa
Human MAPK10-4998H Recombinant Human MAPK10 Protein (Arg88-Ala332), N-His tagged E.coli N-His Arg88-Ala332
Human MAPK10-8439HF Active Recombinant Full Length Human MAPK10 Protein, GST-tagged E.coli GST 1-426
Human MAPK10-1141H Recombinant Human MAPK10 Protein (M1-S423), His tagged E.coli His M1-S423
Human MAPK10-1140H Recombinant Human MAPK10 Protein (M1-S423), Tag Free E.coli No tag M1-S423
Mouse Mapk10-3938M Recombinant Mouse Mapk10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque MAPK10-2671R Recombinant Rhesus monkey MAPK10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAPK10-2491R Recombinant Rhesus Macaque MAPK10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MAPK10-2491R-B Recombinant Rhesus Macaque MAPK10 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAPK10-3593Z Recombinant Zebrafish MAPK10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • MAPK10 Related Signal Pathway

MAPK10 involved in several pathways and played different roles in them. We selected most pathways MAPK10 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayHSP70L;CDC42L2;PLA2G4F;FGFR3;PPM1NB;PRKCG;GRB2B;MAPKAPK2A;PAK2B
ErbB signaling pathwayELK1;ERBB3B;ABL1;SHC3;NRG1;ABL2;RAF1B;GSK3B;MAP2K1
Ras signaling pathwayFGF14;GNG12;GAB1;RASGRP3;RASAL2;PLA2G2F;PLA2G4A;GRIN1;PLA2G6
cAMP signaling pathwayGRIN3B;VIPR2;GRIA1;SUCNR1;PTGER2;MAPK9;F2R;VAV3;PDE4A
FoxO signaling pathwayAKT2L;SMAD3;ATM;KLF2;HRASB;BNIP3;FOXG1;FOXO1;PRKAB2
Sphingolipid signaling pathwayFYN;TRADD;SGMS2;S1PR2;LASS5;RAC3;CERS5;BAX;PRKCG
Protein processing in endoplasmic reticulumRNF185;MAPK8B;CUL1;SEC13;CRYAA;CUL1B;EIF2AK2;LMAN1;RRBP1A
Wnt signaling pathwayBAMBI;RAC3;SFRP4;WNT5B;GPC4;NKD2;PPP3R2;PLCB1;VANGL1
Osteoclast differentiationLILRA4;FCGR1A;NFKB1;LILRB5;ITGB3;TNF;CSF1;TNFRSF11A;MAP2K6
Focal adhesionMYL12.2;HRASA;PTEN;LAMC2;GRB2;TNR;TNK1;PDGFB;COL6A1
Toll-like receptor signaling pathwayIL8L1;IFNA1;TLR1LA;IL12B;MAPK12B;CXCL10;MAPK1;LY96;SPP1
NOD-like receptor signaling pathwayCCL5;CARD9;TRIP6;BIRC3;CARD18;CARD8;CXCL1;CASPA;MAPK12
RIG-I-like receptor signaling pathwayMAPK12B;NLRX1;IFNE;IFNA2;IFNA4;IKBKB;IL12BA;TRAF3;MAP3K1
Fc epsilon RI signaling pathwayPLA2G4A;MAPK8;MAPK13;IL3;BTK;VAV2;MAPK3;LAT;RAC1
TNF signaling pathwayCREB3L2;LIF;MAPK12;MAP3K14;CASP10;IL1B;PIK3R1;MLKL;MAP2K1
Neurotrophin signaling pathwayCALM1;PRKCD;MATK;RAPGEF1;SOS1;MAP3K1;ARHGDIB;PSEN1;SHC2
Retrograde endocannabinoid signalingGABRA5;GABRE;PRKCA;GRIA4;GRIA3;GABRR1;FAAH;Adcy4;GABRP
Dopaminergic synapsePRKACA;CREB5;GNAS;GRIN2A;GNAO1;PPP1CA;CAMK2B;PRKACG;GNAI2
Inflammatory mediator regulation of TRP channelsSRC;CYP2C38;PLA2G4D;MAPK8;CYP2J5;ASIC1;PLCB4;PLCB3;PRKCE
Insulin signaling pathwayRAF1;HRAS;MKNK2B;PRKCZ;PRKAG3;AKT2;PHKG1A;FLOT2B;HK3
GnRH signaling pathwaySOS1;MAP2K4;GNA15.4;NRAS;CDC42;MMP14B;GNAS;PLCB3;MAP2K2A
Progesterone-mediated oocyte maturationPRKACG;AKT2L;CPEB4;PIK3R3B;PPP1R2P9;CPEB3;CDC26;PIK3R2;RAF1A
Prolactin signaling pathwaySOS1;MAPK10;MAPK9;ESR2;PIK3CD;PIK3R5;SHC3;RELA;GSK3B
Adipocytokine signaling pathwayLEPR;PRKAG3;SOCS3;PRKAB1;PCK1;SLC2A1;TNF;ACSL3B;MAPK9
Type II diabetes mellitusPIK3CD;HK2;INS-IGF2;INS;PIK3CG;MAPK9;MAPK3;IRS1;HKDC1
Insulin resistanceAKT2L;PRKCB;PPP1R3C;MAPK10;GSK3B;PRKCQ;PRKAG2;PTPRF;PIK3CG
Non-alcoholic fatty liver disease (NAFLD)NDUFA7;NDUFV2;NDUFS6;PIK3R5;FASLG;NDUFB5;RXRA;Casp3;UQCRB
Epithelial cell signaling in Helicobacter pylori infectionMAPK13;F11R;PTPN11;MAP3K14;ATP6V1G2;ATP6V1G3;ADAM17;IL-8;ATP6V0E1
ShigellosisATG5;WAS;SRC;ELMO2;PFN3;CTTN;WASF1;PFN2;VCL
Salmonella infectionCXCL1;TJP1;WASB;PKN3;CDC42L;CCL3L3;ROCK2;DYNC1LI2;PKN2
PertussisCasp3;MAPK11;AMCF-II;TNF;MAPK1;C1S;MAPK13;MAPK10;MAPK8
Chagas disease (American trypanosomiasis)GNAI1;FOS;PIK3CD;GNAL;CASP8;GNAI3;MAPK13;PIK3R1;PPP2R2C
ToxoplasmosisPIK3R5;LY96;HSPA1A;NFKB1;BAD;IRAK4;LAMC2;LAMA4;Toxoplasma Gondii Major Surface Antigen P30
TuberculosisPPP3R2;RAB7A;FCGR2C;LAMP1;RELA;IL1B;CEBPG;Casp3;HLA-DRB5
Hepatitis CPIK3CD;PIK3R3;PPP2R2B;CD81;RXRA;TYK2;NRAS;OAS2;IFNAR1
Hepatitis BYWHAB;EP300;RB1;IFNA7;IFNA5;IFNA10;ATF4;ATP6AP1;DDX58
Influenza AFAS;PIK3R3;DNAJB1;TLR4;RELA;HSPA8;HLA-DPB1;TNFRSF10B;TLR3
Herpes simplex infectionGLTSCR2;CRFB2;IRF3;MHC1UXA2;C3A.2;HCFC1;EEF1D;PVRL2;IFNAR1
Epstein-Barr virus infectionYWHAB;HLA-B;PSMD3;HLA-C;HSPA2;YWHAH;TRP53;YWHAE;VIM
Pathways in cancerDAPK1;PDGFRB;CYCS;DAPK3;IKBKG;BRCA2;MAX;CASP9;WNT7B
Colorectal cancerTRP53;PIK3CD;SMAD3;RALGDS;TGFB1;TGFB2;MSH6;MAPK1;BCL2
Pancreatic cancerRAC1;VEGFA;AKT2;TGFB1;MAPK9;SMAD2;RAC2;BAD;BRAF
Choline metabolism in cancerMAPK1;PIK3CB;WASF3;TAE1;PCYT1A;PDGFD;RPS6KB1;DGKB;EIF4EBP1

MAPK10 has several biochemical functions, for example, ATP binding, JUN kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK10 itself. We selected most functions MAPK10 had, and list some proteins which have the same functions with MAPK10. You can find most of the proteins on our site.

Function Related Protein
ATP bindingAK5;PAPOLB;HELZ;PRKCH;P2RX2;PRKAG2;FGFR1;ATP6AP1;OASL1
JUN kinase activityALPK2;MAPK10;MAPK9;MAPK8
MAP kinase kinase activityMAP2K7;ALPK2;MAP2K6;MAP3K9;MAP2K3;MAP3K14;MAPK14;MAPKAPK5;MAPK10
protein bindingCHCHD1;SIRT2;PRDM5;LSM11;KCNIP1;TAF2;FHL2;AGRN;RBMS1

MAPK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK10.

ARRB1; JUN; HAX1; RELA; ARRB2; CEP290; GTF3C1; UNC119; TNIP1; CREBBP; PLIN2; KIF26A; linkable pd173955 analogue; gefitinib; WDR62

Research Area

Related articles

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Dhande, I; Ma, WS; et al. Angiotensin AT(2) receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages. HYPERTENSION RESEARCH 38:21-29(2015).
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