MBP

  • Official Full Name

    myelin basic protein

  • Overview

    The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the shiverer and myelin deficient phenotypes in mouse. [provided by RefSeq, Jul 2008]
  • Synonyms

    MBP; myelin basic protein; mld; shi; Hmbpr; C76307; R75289; golli-mbp; shiverer; myelin deficient; myelin A1 protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Cattle
  • Chicken
  • E.coli
  • Human
  • Mouse
  • Pan-species (General)
  • Pig
  • Rabbit
  • Bovine Central Nervous System Tissue
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Brain
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Mouse Central Nervous System
  • Pig Brain
  • porcine brain
  • Swine
  • Biotin
  • C
  • GFP
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • SUMO
  • MBP
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MBP-1469H Recombinant Human Myelin Basic Protein, GST-tagged E.coli GST
Human MBP-9382H Recombinant Human MBP protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MBP-2348H Recombinant Human MBP, His-tagged E.coli His 220aa
Human MBP-6947H Human Myelin basic protein Human Brain N/A
Human MBP-476H Recombinant Human MBP protein, His-tagged HEK293F His Met1~Arg304
Human MBP-2763H Recombinant Human MBP protein, His & GST-tagged E.coli His/GST Val220~Met301
Human MBP-286H Recombinant Human MBP Mammalian Cell His
Human MBP-2764H Recombinant Human MBP protein, His & GST-tagged E.coli His/GST Ala135~Ser190 (Accession # P02686)
Human MBP-4436HCL Recombinant Human MBP 293 Cell Lysate HEK293 N/A
Human MBP-4437HCL Recombinant Human MBP 293 Cell Lysate HEK293 N/A
Human MBP-4438HCL Recombinant Human MBP 293 Cell Lysate HEK293 N/A
Human MBP-1099H Recombinant Human MBP Protein, His&SUMO-tagged E.coli N-His&SUMO Val113-Met183
Human MBP-557H Recombinant Human MBP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MBP-30122H Recombinant Human MBP protein, GST-tagged E.coli GST Met1-Arg171
Human MBP-5372H Recombinant Human MBP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MBP-2915HFL Recombinant Full Length Human MBP protein, Flag-tagged Mamanlian cells Flag
Human MBP-1100H Recombinant Human MBP Protein, His&SUMO-tagged E.coli N-His&SUMO Ala135-Ser190
Human MBP-3445H-B Recombinant Human MBP Protein Pre-coupled Magnetic Beads HEK293
Human MBP-4512H Recombinant Human MBP Protein (Met1-Arg304), C-GFP tagged Mammalian cells C-GFP Met1-Arg304
Human MBP-2527H Recombinant Human MBP protein(101-190 aa), C-His-tagged E.coli C-His 101-190 aa
Human MBP-3956H Recombinant Human MBP protein, His-tagged E.coli His 310aa
Human MBP-4513H Recombinant Human MBP Protein (Met1-Lys192), N-His tagged E.coli N-His Met1-Lys192
Human MBP-3445H Recombinant Human MBP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MBP-6949M Native Mouse Myelin basic protein Mouse Central Nervous System N/A
Mouse Mbp-2765M Recombinant Mouse Mbp protein, His & T7-tagged E.coli His/T7 Asp18~Lys222 (Accession # P04370)
Mouse Mbp-3985M Recombinant Mouse Mbp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rabbit MBP-1771R Recombinant Rabbit MBP protein, His & GST-tagged E.coli His/GST Ala1~Arg168
Bovine MBP-6950B Bovine Myelin basic protein Bovine Central Nervous System Tissue N/A
Bovine MBP-6949B Bovine Myelin basic protein, Biotin-Conjugated Bovine Central Nervous System Tissue Biotin
Cattle MBP-2426C Recombinant Cattle MBP Protein, His-tagged E.coli N-His Ala135-Arg303
E.coli MBP-66E Recombinant E. coli MBP Protein E.coli N/A
Pan-species (General) MBP-2755P Recombinant Pan-species (General) MBP Protein, His/MBP-tagged E.coli N-His/MBP Lys27-Thr392
Pig MBP-6948P Pig Myelin basic protein porcine brain N/A
Pig MBP-99S Native Swine MBP Pig Brain N/A
Pig MBP-89S Native Swine MBP Protein Swine N/A
Pig MBP-50P Recombinant Pig MBP protein, His-tagged E.coli His
Chicken MBP-6832C Recombinant Chicken MBP Mammalian Cell His
MBP-01 Recombinant MBP Protein E.coli Tag Free
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MBP involved in several pathways and played different roles in them. We selected most pathways MBP participated on our site, such as Glial Cell Differentiation, MAPK Cascade, Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glial Cell DifferentiationTPPP;GAP43;CNP;MBP;PLP1
MAPK CascadeMBP;MAP3K2;MBPB;MAP2
Neural Crest DifferentiationHEY2;CDH7;OLIG2;MBP;LHX2;PMP22;CTBP2;OLIG3;TFAP2A
Spinal Cord InjuryKLK8;TNFSF13B;MBP;RTN4R;OMG;LILRB3;LGALS3;GAP43;PTPRZ1

MBP has several biochemical functions, for example, protease binding, protein binding, structural constituent of myelin sheath. Some of the functions are cooperated with other proteins, some of the functions could acted by MBP itself. We selected most functions MBP had, and list some proteins which have the same functions with MBP. You can find most of the proteins on our site.

Function Related Protein
protease bindingADRM1;CCDC71L;INS2;SELL;VWF;ITGA3;F3;ITGB1;MBP
protein bindingNDOR1;TRIM22;KLHL22;ARL6IP4;PABPC1;EBF1;MRPL28;ULK1;CCDC92
structural constituent of myelin sheathMOBP;NCMAP;PLP1;MBPB;MAL;MBP

MBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBP here. Most of them are supplied by our site. Hope this information will be useful for your research of MBP.

CTDSP1; q8iin1_plaf7; PBK; PRMT10; HLA-DRB1; RXRB; ATXN1; ATN1; PDGFRL; APTX; APP; HLA-DRB1; HLA-DMA

Research Area

Related articles

Rao, QC; Hsieh, YHP; et al. Effect of pH, temperature and storage time on the stability of bovine myelin basic protein. FOOD CONTROL 50:166-172(2015).
Saffari, H; Kennedy, A; et al. NON-INVASIVE ULTRASOUND TOIDENTIFY EOSINOPHIL GRANULE PROTEINS IN EOSINOPHILIC ESOPHAGITIS. ULTRASOUND IN MEDICINE AND BIOLOGY 41:884-889(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
12/21/2019

    Product exactly as described.

    07/27/2018

      Worked well in ELISA.

      05/13/2018

        Excellent customer support, helpful.

        Q&As (7)

        Ask a question
        What is the primary function of the MBP gene and its encoded protein? 09/30/2022

        The MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.

        How is MBP expression regulated during neural development? 01/11/2021

        MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.

        What role does MBP play in multiple sclerosis (MS)? 09/29/2020

        In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.

        What are the implications of MBP in demyelinating diseases beyond MS? 09/20/2019

        Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.

        Are there any therapeutic strategies targeting MBP or its pathways in neurodegenerative diseases? 04/30/2019

        Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.

        Are there any known diseases or conditions associated with mutations or dysregulation of MBP? 03/12/2019

        Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.

        How does MBP contribute to the structure and function of myelin sheaths in the nervous system? 07/14/2018

        MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.

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