mbp
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  • Official Full Name
  • myelin basic protein
  • Background
  • The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the shiverer and myelin deficient phenotypes in mouse. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MBP; myelin basic protein; mld; shi; Hmbpr; C76307; R75289; golli-mbp; shiverer; myelin deficient; myelin A1 protein;
Cat.#:MBP-1469HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Myelin Basic Protein, GST-tagged
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Cat.#:MBP-2348HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MBP, His-tagged
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Cat.#:MBP-2763HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MBP protein, His & GST-tagged
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Cat.#:MBP-2764HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MBP protein, His & GST-tagged
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Cat.#:MBP-286HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MBP
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Cat.#:MBP-476HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human MBP protein, His-tagged
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Cat.#:MBP-6947HTag:N/A
Source (Host):Human brainSpecies:Human
Product nameHuman Myelin basic protein
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Cat.#:MBP-9382HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MBP protein, MYC/DDK-tagged
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Cat.#:Mbp-2765MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mbp protein, His & T7-tagged
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Cat.#:MBP-6949BTag:Biotin
Source (Host):bovine central nervous system tissueSpecies:Bovine
Product nameBovine Myelin basic protein, Biotin-Conjugated
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Cat.#:MBP-6950BTag:N/A
Source (Host):bovine central nervous system tissueSpecies:Bovine
Product nameBovine Myelin basic protein
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Cat.#:MBP-1771RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit MBP protein, His & GST-tagged
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Cat.#:MBP-6832CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MBP
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Cat.#:MBP-66ETag:
Source (Host):E. coliSpecies:E.coli
Product nameRecombinant E. coli MBP Protein
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Cat.#:MBP-6948PTag:N/A
Source (Host):Porcine brainSpecies:Pig
Product namePig Myelin basic protein
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Cat.#:MBP-6949MTag:N/A
Source (Host):Porcine brainSpecies:Mouse
Product nameNative Mouse Myelin basic protein
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Cat.#:MBP-89STag:N/A
Source (Host):SwineSpecies:Pig
Product nameNative Swine MBP Protein
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Cat.#:MBP-99STag:
Source (Host):Pig BrainSpecies:Pig
Product nameNative Swine MBP
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Cat.#:MBP-4436HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MBP 293 Cell Lysate
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Cat.#:MBP-4437HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MBP 293 Cell Lysate
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Cat.#:MBP-4438HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MBP 293 Cell Lysate
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Involved Pathway

MBP involved in several pathways and played different roles in them. We selected most pathways MBP participated on our site, such as Glial Cell Differentiation, MAPK Cascade, Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glial Cell Differentiation
MBP; TPPP; GAP43; CNP; PLP1
MAPK Cascade
MBP; MBPB; MAP2; MAP3K2
Neural Crest Differentiation
ZIC1; MIA; PHOX2B; DMBX1; PRTG; HOXA1; PMP22; CDH7; OLIG3; CDH6
Spinal Cord Injury
GAP43; RGMA; NOX4; MBP; KLK8; LGALS3; RTN4; GDNF; AIF1; RTN4R

Protein Function

MBP has several biochemical functions, for example, protease binding, protein binding, structural constituent of myelin sheath. Some of the functions are cooperated with other proteins, some of the functions could acted by MBP itself. We selected most functions MBP had, and list some proteins which have the same functions with MBP. You can find most of the proteins on our site.
Function
Related Protein
Function protease binding
Related Protein CHL1; PYCARD; F3; FADD; HSPA6; FN1; INS2; ECM1; SERPINA1E; TTN
Function protein binding
Related Protein LAIR1; ALDOC; JDP2; SLC22A7; FIBPB; EPN3; SERPINA3; DHX58; SIGIRR; GPM6A
Function structural constituent of myelin sheath
Related Protein PLP1; MOBP; MAL; MBP; NCMAP; MBPB

Interacting Protein

MBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBP here. Most of them are supplied by our site. Hope this information will be useful for your research of MBP.
CTDSP1; q8iin1_plaf7; PBK; PRMT10; HLA-DRB1; RXRB; ATXN1; ATN1; PDGFRL; APTX; APP; HLA-DRB1; HLA-DMA

MBP Related Articles

Rao, QC; Hsieh, YHP; et al. Effect of pH, temperature and storage time on the stability of bovine myelin basic protein. FOOD CONTROL 50:166-172(2015).
Saffari, H; Kennedy, A; et al. NON-INVASIVE ULTRASOUND TOIDENTIFY EOSINOPHIL GRANULE PROTEINS IN EOSINOPHILIC ESOPHAGITIS. ULTRASOUND IN MEDICINE AND BIOLOGY 41:884-889(2015).