Recombinant Human MBP Protein, His (Fc)-Avi-tagged

• Cat.No.: MBP-3445H
• Product Overview: Recombinant Human MBP with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Human
• Tag: His&Fc&Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: MBP myelin basic protein [ Homo sapiens ]
• Official Symbol: MBP
• Gene ID: 4155
• mRNA Refseq: NM_001025081.1
• Protein Refseq: NP_001020252.1
• MIM: 159430
• UniProt ID: P02686

Reviews

12/21/2019

Product exactly as described.

07/27/2018

Worked well in ELISA.

05/13/2018

Excellent customer support, helpful.

Q&As

What is the primary function of the MBP gene and its encoded protein?

The MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.

How is MBP expression regulated during neural development?

MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.

What role does MBP play in multiple sclerosis (MS)?

In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.

What are the implications of MBP in demyelinating diseases beyond MS?

Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.

Are there any therapeutic strategies targeting MBP or its pathways in neurodegenerative diseases?

Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.

Are there any known diseases or conditions associated with mutations or dysregulation of MBP?

Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.

How does MBP contribute to the structure and function of myelin sheaths in the nervous system?

MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.