Recombinant Mouse Mbp protein, His-tagged

Cat.No. : Mbp-644M
Product Overview : Recombinant Mouse Mbp protein(P04370)(1-250aa), fused with N-terminal His tag, was expressed in Yeast.
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Source : Yeast
Species : Mouse
Tag : N-His
Protein length : 1-250aa
Form : If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Molecular Mass : 29.2 kDa
AASequence : MGNHSGKRELSAEKASKDGEIHRGE AGKKRSVGKLSQTASEDSDVFGEAD AIQNNGTSAEDTAVTDSKHTADPKN NWQGAHPADPGNRPHLIRLFSRDAP GREDNTFKDRPSESDELQTIQEDPT AASGGLDVMASQKRPSQRSKYLATA STMDHARHGFLPRHRDTGILDSIGR FFSGDRGAPKRGSGKDSHTRTTHYG SLPQKSQHGRTQDENPVVHFFKNIV TPRTPPPSQGKGGRDSRSGSPMARR
Purity : Greater than 85% as determined by SDS-PAGE.
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.
Gene Name : Mbp myelin basic protein [ Mus musculus ]
Official Symbol : Mbp
Synonyms : MBP; myelin basic protein; Golli-Mbp; myelin basic protein; shiverer; myelin deficient; myelin A1 protein; mld; shi; Hmbpr; C76307; R75289; golli-mbp;
Gene ID : 17196
mRNA Refseq : NM_001025245
Protein Refseq : NP_001020416

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
12/21/2019

    Product exactly as described.

    07/27/2018

      Worked well in ELISA.

      05/13/2018

        Excellent customer support, helpful.

        Q&As (7)

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        What is the primary function of the MBP gene and its encoded protein? 09/30/2022

        The MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.

        How is MBP expression regulated during neural development? 01/11/2021

        MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.

        What role does MBP play in multiple sclerosis (MS)? 09/29/2020

        In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.

        What are the implications of MBP in demyelinating diseases beyond MS? 09/20/2019

        Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.

        Are there any therapeutic strategies targeting MBP or its pathways in neurodegenerative diseases? 04/30/2019

        Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.

        Are there any known diseases or conditions associated with mutations or dysregulation of MBP? 03/12/2019

        Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.

        How does MBP contribute to the structure and function of myelin sheaths in the nervous system? 07/14/2018

        MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.

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