Recombinant Mouse Mbp protein, His-tagged
Cat.No. : | Mbp-644M |
Product Overview : | Recombinant Mouse Mbp protein(P04370)(1-250aa), fused with N-terminal His tag, was expressed in Yeast. |
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Source : | Yeast |
Species : | Mouse |
Tag : | N-His |
Protein length : | 1-250aa |
Form : | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Molecular Mass : | 29.2 kDa |
AASequence : | MGNHSGKRELSAEKASKDGEIHRGE AGKKRSVGKLSQTASEDSDVFGEAD AIQNNGTSAEDTAVTDSKHTADPKN NWQGAHPADPGNRPHLIRLFSRDAP GREDNTFKDRPSESDELQTIQEDPT AASGGLDVMASQKRPSQRSKYLATA STMDHARHGFLPRHRDTGILDSIGR FFSGDRGAPKRGSGKDSHTRTTHYG SLPQKSQHGRTQDENPVVHFFKNIV TPRTPPPSQGKGGRDSRSGSPMARR |
Purity : | Greater than 85% as determined by SDS-PAGE. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. |
Gene Name : | Mbp myelin basic protein [ Mus musculus ] |
Official Symbol : | Mbp |
Synonyms : | MBP; myelin basic protein; Golli-Mbp; myelin basic protein; shiverer; myelin deficient; myelin A1 protein; mld; shi; Hmbpr; C76307; R75289; golli-mbp; |
Gene ID : | 17196 |
mRNA Refseq : | NM_001025245 |
Protein Refseq : | NP_001020416 |
Products Types
◆ Recombinant Protein | ||
MBP-01 | Recombinant MBP Protein | +Inquiry |
MBP-3445H | Recombinant Human MBP Protein, His (Fc)-Avi-tagged | +Inquiry |
Mbp-3985M | Recombinant Mouse Mbp Protein, Myc/DDK-tagged | +Inquiry |
MBP-1099H | Recombinant Human MBP Protein, His&SUMO-tagged | +Inquiry |
MBP-1100H | Recombinant Human MBP Protein, His&SUMO-tagged | +Inquiry |
◆ Native Protein | ||
MBP-89S | Native Swine Myelin Basic Protein | +Inquiry |
MBP-99S | Native Swine Myelin Basic Protein | +Inquiry |
MBP-6949M | Native Mouse Myelin basic protein | +Inquiry |
◆ Lysates | ||
MBP-4437HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4436HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4438HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewProduct exactly as described.
Worked well in ELISA.
Excellent customer support, helpful.
Q&As (7)
Ask a questionThe MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.
MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.
In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.
Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.
Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.
Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.
MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.
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