Recombinant Mouse Mbp Protein, Myc/DDK-tagged
Cat.No. : | Mbp-3985M |
Product Overview : | Purified recombinant protein of mouse full-length myelin basic protein (Mbp), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
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Description : | The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc&DDK |
Molecular Mass : | 20.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Mbp myelin basic protein [ Mus musculus (house mouse) ] |
Official Symbol : | Mbp |
Synonyms : | MBP; myelin basic protein; Golli-Mbp; myelin basic protein; shiverer; myelin deficient; myelin A1 protein; mld; shi; Hmbpr; C76307; R75289; golli-mbp |
Gene ID : | 17196 |
mRNA Refseq : | NM_001025254 |
Protein Refseq : | NP_001020425 |
UniProt ID : | P04370 |
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◆ Native Protein | ||
MBP-99S | Native Swine Myelin Basic Protein | +Inquiry |
MBP-89S | Native Swine Myelin Basic Protein | +Inquiry |
MBP-6949M | Native Mouse Myelin basic protein | +Inquiry |
◆ Lysates | ||
MBP-4438HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4436HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
MBP-4437HCL | Recombinant Human MBP 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewProduct exactly as described.
Worked well in ELISA.
Excellent customer support, helpful.
Q&As (7)
Ask a questionThe MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.
MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.
In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.
Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.
Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.
Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.
MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.
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