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Official Full Name Mediator complex subunit 10
Background MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.
Synonyms MED10; mediator complex subunit 10; L6; NUT2; TRG20; mediator of RNA polymerase II transcription subunit 10; TRG-17; TRG-20; transformation-related gene 17 protein; HNUT2; MGC5309; transformation-related gene 20 protein; mediator of RNA polymerase II transcription, subunit 10; mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae); OTTHUMP00000220564
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED10-3064H Recombinant Human MED10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MED10-4393HCL Recombinant Human MED10 293 Cell Lysate HEK293 N/A
    Human MED10-801H Recombinant Human MED10, GST-tagged E.coli GST
    Mouse Med10-4012M Recombinant Mouse Med10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MED10-9680M Recombinant Mouse MED10 Protein Mammalian Cell His
    Cynomolgus Monkey MED10-683C Recombinant Cynomolgus MED10 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque MED10-2716R Recombinant Rhesus monkey MED10 Protein, His-tagged Mammalian Cell His
    Zebrafish MED10-2457Z Recombinant Zebrafish MED10 Mammalian Cell His

    med10 involved in several pathways and played different roles in them. We selected most pathways med10 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with med10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology SEMA4D; MED15; PAK4; GFRA1; ARPC5; COL9A1; SPTBN1; CLASP1; DUSP2; SIAH2
    Fatty acid, triacylglycerol, and ketone body metabolism AGPAT1; MED31; MED10; CDK19; ANKRD1; CPT1B; GLIPR1; MED19; ACAD11; APOA5
    Gene Expression ZNF394; SAP18; C2orf49; ZNF157; ANP32A; ZNF3; TRDMT1; RARAA; ZNF710; ZNF484
    Generic Transcription Pathway NRBF2; ZNF443; VDRB; JUNB; ZNF446; ZNF19; ZNF583; ZNF671; MED20; ZNF114
    Metabolism ACOT2; CYP2N13; SLC44A5B; ACAD11; SLC5A2; AQP1A.1; FABP11A; HSD17B11; CDIPT; YAP1
    Metabolism of lipids and lipoproteins SLC44A5B; FABP12; AKR1C21; FABP11B; CYP4F22; SCP2B; PITPNB; FABP1B.1; GLTPA; DGAT1B
    PPARA activates gene expression MED10; SREBF2; GLIPR1; MED15; MED18; G0S2; GRHL1; MED29; MED19; TIAM2
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) GLIPR1; MED10; MED31; MED18; ANKRD1; MED15; MED22; MED23; MED6; MED9

    med10 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by med10 itself. We selected most functions med10 had, and list some proteins which have the same functions with med10. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity MED19B; MED13L; MDT-19; MED18; MED26; NKX2; MED1; MED20; NKX2-5; MED4
    protein binding SOX1; PDE4D; BRPF3; EXOSC3; TEAD4; SEC24A; CCDC43; SCAF8; CAML; RPL37A
    ubiquitin protein ligase activity RNF217; UBR5; SIAH1A; LRSAM1; NHLRC1; RNF19B; UBE2J2; UBE2V1; UBE2U; RNF41

    med10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with med10 here. Most of them are supplied by our site. Hope this information will be useful for your research of med10.

    MED19; MED8; MED17

    Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
    Wu, YM; Chang, JW; et al. Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM. EMBO JOURNAL 31:3575-3587(2012).

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