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MED12

Official Full Name

mediator complex subunit 12
Overview

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
Synonyms

MED12; mediator complex subunit 12; OKS; FGS1; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230; mediator of RNA polymerase II transcription subunit 12; CAG repeat protein 45; human opposite paired; OPA-containing protein; putative mediator subunit 12; activator-recruited cofactor 240 kDa component; trinucleotide repeat-containing gene 11 protein; thyroid hormone receptor-associated protein, 230 kDa subunit; mediator of RNA polymerase II transcription, subunit 12 homolog; thyroid hormone receptor-associated protein complex 230 kDa component; trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit);

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	MED12-4479H	Recombinant Human MED12 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Mouse	MED12-9682M	Recombinant Mouse MED12 Protein	Mammalian Cell	His	Inquiry
Mouse	MED12-5443M	Recombinant Mouse MED12 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	MED12-5443M-B	Recombinant Mouse MED12 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	MED12-3618Z	Recombinant Zebrafish MED12	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
MED12 Related Research Area

MED12 involved in several pathways and played different roles in them. We selected most pathways MED12 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Thyroid hormone signaling pathway	THRA;AKT2;SLC16A10;NOTCH2;NOTCH3;RHEB;PLCD1;EP300;ACTG1

MED12 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding, RNA polymerase II transcription coactivator activity, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED12 itself. We selected most functions MED12 had, and list some proteins which have the same functions with MED12. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II distal enhancer sequence-specific DNA binding	HNRNPC;CDX1;SIX3;MEOX2;RUVBL2;TAL1;RELA;CREB1;H3F3A
RNA polymerase II transcription coactivator activity	ISL1;TBX20;WBP2;PRRX1;PSIP1;CITED2;CREBBP;MKL1B;POU1F1
RNA polymerase II transcription cofactor activity	MED31;MED24;MED26;MED21;MED19B;FOXH1;NKX2-5;MED14;PPARGC1A
beta-catenin binding	GRIP1;GSK3B;KLF4;NF2;NUMB;CARM1;CD2AP;SLC9A3R2;HDAC6
chromatin binding	RFX4;ZMYND11;RNF2;SOX10;RBPJ;TP53;CHD7;TCF7L1B;UBE2T
protein C-terminus binding	COIL;CSK;FOXN3;NEFL;PEX12;PDZD11;NCF2;PEX10;PROP1
protein binding	CD28;KLRC2;DZIP3;HYPM;IL1RN;RUSC1-AS1;C6orf211;FHL3;STEAP3
protein domain specific binding	HIST1H4N;XPA;HPCAL4;NR0B1;SHC4;HIST4H4;TJP2;DDX20;PPP3R1
receptor activity	GPA33;CD1D;ITGB8;ITGB1A;GRIA4A;CD86;AMFR;NLGN3B;OR3A2
thyroid hormone receptor binding	NSD1;MED24;THRAP3;TAF7;OASL;FUS;HMGN3;TAF11;MED1
transcription coactivator activity	TAF1;MLL5;TRIM32;TBPL1;MNT;ABT1;CCAR1;TAF9;HAND1
transcription cofactor activity	HES6;TRIP13;ZFP865;PSMC5;NFKBIZ;ELK4;LDB2B;MED13;TFB2M
transcription factor binding	HES4;HAND1;NIF3L1;SRY;TFDP1B;TRIB1;ADD1;GTF2A1;HDAC1
transcriptional activator activity, RNA polymerase II transcription factor binding	NOTCH1;SOX10;FOXH1;WWP2;NFE2L1;CREB1;NKX2;CLOCK;PITX1
contributes_to ubiquitin protein ligase activity	FBXL3A;CUL1;CUL2;FBXL12;CUL1B;ANAPC2;FBXL7;CUL1A;FBXL3

MED12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED12.

TGFBR2; Foxp3; Ywhae; Tfcp2l1; Tada2a; Kat2a

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