MED12

  • Official Full Name

    mediator complex subunit 12

  • Overview

    The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

  • Synonyms

    MED12;mediator complex subunit 12;OKS;FGS1;HOPA;OPA1;OHDOX;ARC240;CAGH45;MED12S;TNRC11;TRAP230;mediator of RNA polymerase II transcription subunit 12;CAG repeat protein 45;human opposite paired;OPA-containing protein;putative mediator subunit 12;activator-recruited cofactor 240 kDa component;trinucleotide repeat-containing gene 11 protein;thyroid hormone receptor-associated protein, 230 kDa subunit;mediator of RNA polymerase II transcription, subunit 12 homolog;thyroid hormone receptor-associated protein complex 230 kDa component;trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)
Cat.# Product name Source (Host) Species Tag Protein Length Price
MED12-3618Z Recombinant Zebrafish MED12 Mammalian Cells Zebrafish His
MED12-9682M Recombinant Mouse MED12 Protein Mammalian Cells Mouse His
MED12-4479H Recombinant Human MED12 Protein, GST-tagged Wheat Germ Human GST
MED12-5443M Recombinant Mouse MED12 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MED12-5443M-B Recombinant Mouse MED12 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    MED12 involved in several pathways and played different roles in them. We selected most pathways MED12 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway NCOR1,SLC2A1,MAPK1,PRKACG,DIO3,ATP1B4,RXRG,PLCB1,ATP1A3,TP53

    Protein Function

    MED12 has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding,RNA polymerase II transcription coactivator activity,RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED12 itself. We selected most functions MED12 had, and list some proteins which have the same functions with MED12. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PPP1R2P9,FAM134C,GPATCH4,PTPN9,ZNF792,KCTD9,LDLR,IRS4,TGFBR1,PGRMC1
    beta-catenin binding TBL1XR1,TCF7L1B,TAX1BP3,DACT1,SMAD7,PSEN1,NUMB,DVL3,ESR1,SLC9A3R2
    transcription coactivator activity FHL2,FHL5,PRDM16,BRDT,MKL1,KLF7,ASXL1,SOX10,TAF7,SUPT3H
    protein domain specific binding TACC3,ARRB2,HPCAL4,WNT3,GABRR3,RAPGEF3,HIST1H4J,DBNL,IST1,ERCC1
    protein C-terminus binding SP1,PROP1,BLOC1S2A,CEP135,CACNA1B,VPS4A,PEX16,PEX12,CSK,KCNK3
    thyroid hormone receptor binding MED17,TAF7,PRMT2,NSD1,NUP62,GAS2L1,ZNHIT3,MED16,TAF11,NCOA3
    receptor activity NEO1,LDLR,CD244,DERL1,ITGB1B.1,CXCR3,UNC13B,FPR1,ATRN,PAQR9
    contributes_to ubiquitin protein ligase activity FBXL3B,CUL3,KDM2BA,CUL1B,FBXL2,CUL1A,FBXL17,UBXN6,C10orf46,FBXL12
    transcriptional activator activity, RNA polymerase II transcription factor binding NR1H4,NFE2L1,FOXH1,PPARA,GBX2,MIXL1,NKX2,CLOCK,WWP2,KLF4

    Interacting Protein

    MED12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED12.

    TGFBR2;Foxp3;Ywhae;Tfcp2l1;Tada2a;Kat2a

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