Recombinant Human MED12 Protein, GST-tagged
Cat.No. : | MED12-4479H |
Product Overview : | Human MED12 partial ORF ( NP_005111, 1829 a.a. - 1941 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 38.17 kDa |
AA Sequence : | QPATKTEDYGMGPGRSGPYGVTVPP DLLHHPNPGSITHLNYRQGSIGLYT QNQPLPAGGPRVDPYRPVRLPMQKL PTRPTYPGVLPTTMTGVMGLEPSSY KTSVYRQQQPAVP |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | MED12 mediator complex subunit 12 [ Homo sapiens ] |
Official Symbol : | MED12 |
Synonyms : | MED12; mediator complex subunit 12; FG syndrome 1 , FGS1, mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae) , TNRC11, trinucleotide repeat containing 11 (THR associated protein, 230kDa subunit); mediator of RNA polymerase II transcription subunit 12; CAGH45; HOPA; KIAA0192; OKS; OPA1; TRAP230; CAG repeat protein 45; human opposite paired; OPA-containing protein; putative mediator subunit 12; activator-recruited cofactor 240 kDa component; trinucleotide repeat-containing gene 11 protein; thyroid hormone receptor-associated protein, 230 kDa subunit; mediator of RNA polymerase II transcription, subunit 12 homolog; thyroid hormone receptor-associated protein complex 230 kDa component; trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit); FGS1; ARC240; MED12S; TNRC11; |
Gene ID : | 9968 |
mRNA Refseq : | NM_005120 |
Protein Refseq : | NP_005111 |
MIM : | 300188 |
UniProt ID : | Q93074 |
Products Types
◆ Recombinant Protein | ||
MED12-5443M | Recombinant Mouse MED12 Protein, His (Fc)-Avi-tagged | +Inquiry |
MED12-9682M | Recombinant Mouse MED12 Protein | +Inquiry |
MED12-3618Z | Recombinant Zebrafish MED12 | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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