Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

MED14

Official Full Name

mediator complex subunit 14
Overview

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
Synonyms

MED14; mediator complex subunit 14; cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa , CRSP2, CXorf4; mediator of RNA polymerase II transcription subunit 14; CRSP150; CSRP; EXLM1; RGR1; TRAP170; hRGR1; ARC150; RGR1 homolog; CRSP com;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MED14-802H	Recombinant Human MED14, His-tagged	E.coli	His	1103-1454aa	$319 / 25ug
Mouse	MED14-9686M	Recombinant Mouse MED14 Protein	Mammalian Cell	His		Inquiry
Mouse	MED14-5446M	Recombinant Mouse MED14 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MED14-5446M-B	Recombinant Mouse MED14 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MED14-12034Z	Recombinant Zebrafish MED14	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MED14 involved in several pathways and played different roles in them. We selected most pathways MED14 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Thyroid hormone signaling pathway	MDM2;NOTCH3;PLCB4;CASP9;PIK3R1;MED4;PLCB2;PLCG1;ATP1A2

MED14 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, ligand-dependent nuclear receptor transcription coactivator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED14 itself. We selected most functions MED14 had, and list some proteins which have the same functions with MED14. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II transcription cofactor activity	MED9;PPARGC1A;MED15;MED13A;TP53BP1;MED1;MED14;FOXH1;MDT-19
ligand-dependent nuclear receptor transcription coactivator activity	HMGA1-RS1;ACTN4;SFR1;RBM14;KDM1A;THRAP3;PPARGC1B;TSG101;ZCCHC18
protein binding	SNCAIP;ZSCAN12;PIM2;TIA1;TTLL10;CALU;RERE;ADIPOQ;TTR
receptor activity	TMEM123;NOTCH2;TNFRSF13B;TLR4;MED24;RTN4R;TREM1;CLEC4M;ITGB1B
transcription coactivator activity	MED7;RNF4;DDX5;MED17;ATF6;MLL5;MED23;WNT3A;TCF3
transcription cofactor activity	SLC26A3;CREB1;HES6;ZNF212;KAT2B;PIR;FAM48A;LDB1A;AIRE
vitamin D receptor binding	MED4;RUNX2B;MED14;SNW1;MED30;TAF7;MED17;MED16;RXRA

MED14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED14.

MED10; MED19; CDK8; CDK19; MED26; MED9; MED24; ABL1