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MED19

Official Full Name

mediator complex subunit 19
Overview

MED19 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Synonyms

MED19; mediator complex subunit 19; LCMR1; DT2P1G7; mediator of RNA polymerase II transcription subunit 19; lung cancer metastasis-related protein 1; mediator of RNA polymerase II transcription, subunit 19 homolog;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MED19-362H	Recombinant Human MED19 Protein, His-tagged	E.coli	His		Inquiry
Human	MED19-4390HCL	Recombinant Human MED19 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MED19-6213HF	Recombinant Full Length Human MED19 Protein, GST-tagged	In Vitro Cell Free System	GST	194 amino acids	Inquiry
Human	MED19-4474H	Recombinant Human MED19 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	MED19-9691M	Recombinant Mouse MED19 Protein	Mammalian Cell	His		Inquiry
Mouse	MED19-5449M-B	Recombinant Mouse MED19 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MED19-5449M	Recombinant Mouse MED19 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MED19 Related Articles

MED19 involved in several pathways and played different roles in them. We selected most pathways MED19 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Developmental Biology	MYF6;PTPRA;MED21;DUSP9;KALRN;EZRA;COL4A4;RHOAE;RASGRP1
Fatty acid, triacylglycerol, and ketone body metabolism	ACSF3;MED26;MED19;TMEM195;DGAT1B;ECI1;ACOT2;ACOT11A;ABCA1
Metabolism	TPH2;LBR;NUBP1;DDAH2;PIK3R6;IDO2;CIAO1;SLC25A20;CYP2W1
Metabolism of lipids and lipoproteins	CYP4F11;GGTLC1;PPARGC1B;CEPT1;ARV1;CSNK1G2;APOA4B.2;CERS5;FABP11B
PPARA activates gene expression	CTGF;MTF1;MED31;APOA5;MED26;GLIPR1;GRHL1;MED10;MED23
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	MED9;MED21;MED29;MED26;MED23;CDK19;MED7;MED10;MTF1
Transcriptional regulation of white adipocyte differentiation	EBF1;MED19;MED9;MED22;MED29;NR2F2;CDK19;EGR2;MED18

MED19 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED19 itself. We selected most functions MED19 had, and list some proteins which have the same functions with MED19. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II transcription cofactor activity	TP53BP1;TDG;MED9;MED14;MED22;NKX2-5;THRAP3;MED26;MED1
protein binding	ZNF202;FAM167A;STX4;LSM7;ZFYVE19;METTL15;METTL21C;AARSD1;GSTA2

MED19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED19 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED19.

MED10; MED29

Wu, YM; Chang, JW; et al. Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM. EMBO JOURNAL 31:3575-3587(2012).