MED24

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MED24

Official Full Name mediator complex subunit 24
Background This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Synonyms MED24; mediator complex subunit 24; cofactor required for Sp1 transcriptional activation, subunit 4, 100kDa , CRSP4, THRAP4, thyroid hormone receptor associated protein 4; mediator of RNA polymerase II transcription subunit 24; CRSP100; DRIP100; KIAA0130
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED24-10H Recombinant Human MED24 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MED24-350H Recombinant Human MED24 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MED24-4386HCL Recombinant Human MED24 293 Cell Lysate HEK293 N/A
    Human MED24-4472H Recombinant Human MED24 Protein, GST-tagged Wheat Germ GST
    Human MED24-823H Recombinant Human MED24 Mammalian Cell His
    Mouse Med24-4016M Recombinant Mouse Med24 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MED24-9696M Recombinant Mouse MED24 Protein Mammalian Cell His
    Rat MED24-3637R Recombinant Rat MED24 Protein Mammalian Cell His
    Chicken MED24-3016C Recombinant Chicken MED24 Mammalian Cell His
    Zebrafish MED24-3603Z Recombinant Zebrafish MED24 Mammalian Cell His

    MED24 involved in several pathways and played different roles in them. We selected most pathways MED24 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway ATP1B2; RAF1; RXRA; ATP1B4; FXYD2; ATP1B3; FOXO1; ACTG1; PRKACB; NOTCH1

    MED24 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, histone acetyltransferase activity, ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED24 itself. We selected most functions MED24 had, and list some proteins which have the same functions with MED24. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity MED26; TDG; MED21; MED14; MED13; MED9; PPARGC1B; THRAP3; NKX2-5; PPARGC1A
    histone acetyltransferase activity KAT2A; MED24; CREBBP; KAT2B; KAT7; GTF3C4; vnc; KAT6B; KAT7A; KAT6A
    ligand-dependent nuclear receptor transcription coactivator activity MED14; CARM1; NCOA1; MED1; ZCCHC12; SLC30A9; PPARGC1A; SFR1; USP22; TADA3
    protein binding PIP4K2B; SDC4; FADD; ENTPD1; MUC7; PRPF8; FIS1; Trf; RIMS1; FDXR
    receptor activity VMN1R46; BTN1A1; MED24; CD1D; TLR2; ATP6AP2; NRXN1; RAMP1; CMKLR1; NPR2
    thyroid hormone receptor binding TAF11; ZNHIT3; PRMT2; NCOA3; TRIP12; FUS; NSD1; NCOR1; MED17; MED30
    transcription cofactor activity TMF1; NFE2L1; PRKCBP1L; CREB1; IRF3; BTG1; PTPN14; ZNF212; POU2AF1; WDR75
    ubiquitin protein ligase activity ZNRF2; UBE2C; RNF7; RABGEF1; CBLL1; BRAP; RNF146; RNF121; RNF115; ANAPC11
    vitamin D receptor binding MED17; MED16; SNW1; RUNX2B; THRAP3; RXRA; TAF11; MED24; MED14; MED30

    MED24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED24 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED24.

    MED10; CDK19; MED19; CDK8; MED9; Dlg4; MED14; CCNC; SMAD2; SMAD1; MED25; MED16

    Chen, YR; Chen, CL; et al. Mitochondrial complex II in the post-ischemic heart - Oxidative injury and the role of protein S-glutathionylation. JOURNAL OF BIOLOGICAL CHEMISTRY 282:32640-32654(2007).

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