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Official Full Name mediator complex subunit 26
Background The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
Synonyms MED26; mediator complex subunit 26; cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa , CRSP7; mediator of RNA polymerase II transcription subunit 26; CRSP70; ARC70; CRSP complex subunit 7; transcriptional coactivator CRSP70; activato
    • Species :
    • Human
    • Mouse
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED26-1908H Recombinant Human MED26 Protein, GST-tagged Wheat Germ GST
    Human MED26-406HCL Recombinant Human MED26 cell lysate N/A
    Mouse MED26-9698M Recombinant Mouse MED26 Protein Mammalian Cell His

    med26 involved in several pathways and played different roles in them. We selected most pathways med26 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with med26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology MYL12A; EBF1; TDGF1; EPHA10; RHOB; MYF6; SPTB; MED25; NTN1A; ARPC1A
    Fatty acid, triacylglycerol, and ketone body metabolism GLIPR1; ACOT9.1; ACOT8; MED22; MED6; GPAT2; THEM5; MMAA; MED10; ACOT6
    Gene Expression TDRD1; CCNC; EIF4B; ZNF705A; ZNF558; THOC4; ARHGEF38; PHF1; RORAA; NR6A1A
    Generic Transcription Pathway ZNF583; ZNF264; ZNF577; ZNF550; ZNF624; ZNF567; ZNF560; ZNF792; COX18; MED6
    Metabolism LRPPRC; SLC5A9; AKR1C21; CIAO1; SLC52A3; UGT1B2; TIMMDC1; DBH; PTGR1; KCNS3
    Metabolism of lipids and lipoproteins FABP9; Alb; MED31; CPNE6; CYP4T8; SGMS2; ELOVL1A; PTGDSA; CERS5; PLBD1
    PPARA activates gene expression MTF1; MED21; SREBF2; MED19; MED8; CDK19; TIAM2; MED10; GLIPR1; MED15
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED25; MED22; MED26; GRHL1; MED20; MED16; ANKRD1; MED9; GLIPR1; MED29

    med26 has several biochemical functions, for example, DNA binding, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by med26 itself. We selected most functions med26 had, and list some proteins which have the same functions with med26. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HIST1H2AM; GATA4; SOS1; RBFOX3; EPAS1B; ZNF239; HOXD11A; CERS5; GM14476; TRIM16
    RNA polymerase II transcription cofactor activity MED13L; MED18; MED24; PPARGC1B; MED14; MED10; MED31; MED11; MED1; MED4
    protein binding NANOS2; DDX19A; KCNA3; BBS12; RPA3; CRBN; GPR3; MBD1; CYP4F2; CANX
    transcription coactivator activity JUND; TAF7; HCFC2; BIRC2; PRMT2; LPIN1; RIPK3; NFYC; RBPMS; ARL2BP

    med26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with med26 here. Most of them are supplied by our site. Hope this information will be useful for your research of med26.

    MED10; MED7; CDK19

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