|Official Full Name||mediator complex subunit 6|
|Background||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|
|Synonyms||MED6; mediator complex subunit 6; ARC33; NY-REN-28; mediator of RNA polymerase II transcription subunit 6; CTD-2540L5.5; renal carcinoma antigen NY-REN-28; activator-recruited cofactor 33 kDa component;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MED6 involved in several pathways and played different roles in them. We selected most pathways MED6 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Developmental Biology||TRPC7; EPHA10; CLTA; INSM1B; COL6A2; FRS3; ACTR3; ACTR2B; ITGB3A; CFC1|
|Fatty acid, triacylglycerol, and ketone body metabolism||ACAD11; ECI1; MED25; ACSF3; STIL; APOA5; AGPAT6; ACOT12; ACOT10; AGPAT2|
|Gene Expression||TRMT1; ZNF563; DCP2; LSM11; UBTF; HNRNPF; MED20; GTF3C4; ZNF596; RXRBB|
|Generic Transcription Pathway||ZNF839; ZNF577; ZNF70; RARAB; ZNF34; ZNF606; MED13A; ZNF621; PSTPIP2; MED25|
|Metabolism||MED16; CLPS; GPHN; CYP2R1; NUDT5; FA2H; GPAT2; ADHFE1; D2HGDH; UROC1|
|Metabolism of lipids and lipoproteins||SLC44A5B; CTGF; FIG4; SACM1LA; ALOX5B.3; CDIPT; CYP2U1; CYP2V1; PLIN2; ALOX5AP|
|PPARA activates gene expression||CTGF; MED6; SREBF2; MED8; GLIPR1; MED9; CDK19; MED26; MED25; MED15|
|Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)||MED26; CTGF; CDK19; MED6; MED18; PLIN2; MED19; MED7; MED31; MED23|
MED6 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly, protein binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED6 itself. We selected most functions MED6 had, and list some proteins which have the same functions with MED6. You can find most of the proteins on our site.
|RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly||MED6|
|protein binding||FAM58A; OAS1A; GHITM; PRF1; GRK5; SP140; NELL2; CDC34; ZCCHC11; VCAN|
|transcription coactivator activity||RXRA; MAML2; RARA; YAP1; ARID1A; ARL2BP; USP22; KAT2B; ENY2; ATF6|
|transcription factor binding||KAT2A; PPP1R13B; TAF12; NFKBIA; HEYL; NEUROD1; FOXA1; DIP2BA; MECP2; MED12|
MED6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED6.
MED10; MED29; MED19; CDK19; MED26; CDK8