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Official Full Name mediator complex subunit 6
Background Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Synonyms MED6; mediator complex subunit 6; ARC33; NY-REN-28; mediator of RNA polymerase II transcription subunit 6; CTD-2540L5.5; renal carcinoma antigen NY-REN-28; activator-recruited cofactor 33 kDa component;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED6-131H Recombinant Human MED6 protein, T7-tagged E.coli T7
    Human MED6-4380HCL Recombinant Human MED6 293 Cell Lysate HEK293 N/A
    Human MED6-4466H Recombinant Human MED6 Protein, GST-tagged Wheat Germ GST
    Human MED6-557H Recombinant Human MED6 Protein, His-tagged E.coli His
    Human MED6-841H Recombinant Human Mediator Complex Subunit 6, T7-tagged E.coli T7
    Mouse MED6-9705M Recombinant Mouse MED6 Protein Mammalian Cell His
    Chicken MED6-3945C Recombinant Chicken MED6 Mammalian Cell His
    Zebrafish MED6-316Z Recombinant Zebrafish MED6 Mammalian Cell His

    MED6 involved in several pathways and played different roles in them. We selected most pathways MED6 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology TRPC7; EPHA10; CLTA; INSM1B; COL6A2; FRS3; ACTR3; ACTR2B; ITGB3A; CFC1
    Fatty acid, triacylglycerol, and ketone body metabolism ACAD11; ECI1; MED25; ACSF3; STIL; APOA5; AGPAT6; ACOT12; ACOT10; AGPAT2
    Gene Expression TRMT1; ZNF563; DCP2; LSM11; UBTF; HNRNPF; MED20; GTF3C4; ZNF596; RXRBB
    Generic Transcription Pathway ZNF839; ZNF577; ZNF70; RARAB; ZNF34; ZNF606; MED13A; ZNF621; PSTPIP2; MED25
    Metabolism MED16; CLPS; GPHN; CYP2R1; NUDT5; FA2H; GPAT2; ADHFE1; D2HGDH; UROC1
    Metabolism of lipids and lipoproteins SLC44A5B; CTGF; FIG4; SACM1LA; ALOX5B.3; CDIPT; CYP2U1; CYP2V1; PLIN2; ALOX5AP
    PPARA activates gene expression CTGF; MED6; SREBF2; MED8; GLIPR1; MED9; CDK19; MED26; MED25; MED15
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED26; CTGF; CDK19; MED6; MED18; PLIN2; MED19; MED7; MED31; MED23

    MED6 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly, protein binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED6 itself. We selected most functions MED6 had, and list some proteins which have the same functions with MED6. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly MED6
    protein binding FAM58A; OAS1A; GHITM; PRF1; GRK5; SP140; NELL2; CDC34; ZCCHC11; VCAN
    transcription coactivator activity RXRA; MAML2; RARA; YAP1; ARID1A; ARL2BP; USP22; KAT2B; ENY2; ATF6
    transcription factor binding KAT2A; PPP1R13B; TAF12; NFKBIA; HEYL; NEUROD1; FOXA1; DIP2BA; MECP2; MED12

    MED6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED6.

    MED10; MED29; MED19; CDK19; MED26; CDK8

    Ruiz, A; Pauls, E; et al. Characterization of the Influence of Mediator Complex in HIV-1 Transcription. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27665-27676(2014).
    Lariviere, L; Plaschka, C; et al. Structure of the Mediator head module. NATURE 492:448-+(2012).

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