MGAT4A
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Official Full Name
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
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Background
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. -
Synonyms
MGAT4A; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A; mannosyl (alpha 1,3 ) glycoprotein beta 1,4 N acetylglucosaminyltransferase, isoenzyme A; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferas;
- Involved Pathway
- Protein Function
- Interacting Protein
MGAT4A involved in several pathways and played different roles in them. We selected most pathways MGAT4A participated on our site, such as Asparagine N-linked glycosylation, Metabolic pathways, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Asparagine N-linked glycosylation | SLC35A1;MPDU1;CNIH2;ST8SIA3;TRAPPC10;TMED10;TRAPPC2L;MCFD2;LMAN2L |
| Metabolic pathways | NME5;UQCRC2B;ANPEP;HSD17B8;PTGS2A;AOX3;SDHB;ST6GALNAC5;SPS2 |
| Metabolism of proteins | MPDU1B;MUC4;CPE;EXOC8;ARSH;ADAMTS8;TMED2;EIF5;CHCHD4 |
| N-Glycan antennae elongation | MGAT4A;MGAT4B;ST8SIA3;ST8SIA2 |
| N-Glycan biosynthesis | MOGS;DPM1;ALG10B;B4GALT3;ALG6;ZNF408;B4GALT1;MAN2A1;MGAT2 |
| N-glycan antennae elongation in the medial/trans-Golgi | ST8SIA3;ST8SIA2;MGAT4B;MGAT4A |
| Post-translational protein modification | NEU4;TRAPPC2L;ALG14;EID3;MUC1;PPP6C;MUC13;B3GNT8;RING1 |
| Transport to the Golgi and subsequent modification | SEC23IP;BET1;ANKRD28;PPP6R1;TRAPPC10;PPP6R3;SCFD1;TMED10;TRAPPC6A |
MGAT4A has several biochemical functions, for example, alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT4A itself. We selected most functions MGAT4A had, and list some proteins which have the same functions with MGAT4A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | MGAT4A;MGAT4B;4931440L10Rik;MGAT4C |
| metal ion binding | ZFP90;CNOT6;CACNA1D;FOXP1;TRP53;ZDHHC18A;ZNF292A;ADK;FAHD2B |
MGAT4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT4A here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT4A.
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