mgst2 Protein, microsomal glutathione S-transferase 2


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Official Full Name microsomal glutathione S-transferase 2
Background The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Synonyms MGST2; microsomal glutathione S-transferase 2; MGST II; FLJ27438; GST 2; GST2; MGC14097; MGST 2; MGSTII; Microsomal glutathione S transferase 2; Microsomal GST 2; Microsomal GST II; microsomal GST-2; microsomal GST-II; MGST-II
    • Species :
    • Cynomolgus Monkey
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MGST2-4327HCL Recombinant Human MGST2 293 Cell Lysate HEK293 N/A
    Human MGST2-5310H Recombinant Human MGST2 Protein, GST-tagged Wheat Germ GST
    Cynomolgus Monkey MGST2-693C Recombinant Cynomolgus MGST2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque MGST2-2766R Recombinant Rhesus monkey MGST2 Protein, His-tagged Mammalian Cell His
    Zebrafish MGST2-4292Z Recombinant Zebrafish MGST2 Mammalian Cell His

    mgst2 involved in several pathways and played different roles in them. We selected most pathways mgst2 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with mgst2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glutathione metabolism SMS; GPX1A; GPX4B; GGCTA; ANPEPB; GSTK1; GSTO1; GSR; GSTM3; GPX2
    Metabolism of xenobiotics by cytochrome P CBR1; UGT1A2; SULT2A1; UGT1A7C; UGT1A7; GSTM6; DHDH; CBR3; GSTT1B; GSTM
    Drug metabolism - cytochrome P GSTT2; GSTM6; MGST3; UGT1AB; ALDH3A1; GSTM5; GSTA2; UGT1A6B; UGT2A3; UGT1A1
    Chemical carcinogenesis CYP2C55; EPHX1; ADH7; ADH2-2; GSTT1; UGT1A1; CYP1A1; UGT1A7; MGST1; ADH6

    mgst2 has several biochemical functions, for example, enzyme activator activity, glutathione peroxidase activity, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by mgst2 itself. We selected most functions mgst2 had, and list some proteins which have the same functions with mgst2. You can find most of the proteins on our site.

    Function Related Protein
    enzyme activator activity GM1679; GMFG; DAOA; CFLAR; SLX4; MMP16; CLPSL1; MMP24; DBF4; PSAP
    glutathione peroxidase activity MGST2; GPX1A; GSTK1; GPX8; GPX5; GPX1; GPX7; GPX2; MGST3; LTC4S
    glutathione transferase activity GSTA; GSTM3; GSTM; GSTZ1; GSTA3; GSTM4; HPGDS; GSTAL; GSTT1; GDAP1L1
    leukotriene-C4 synthase activity MGST2; LTC4S

    mgst2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mgst2 here. Most of them are supplied by our site. Hope this information will be useful for your research of mgst2.

    Weng, ZQ; Greenhaw, J; et al. Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes. TOXICOLOGY LETTERS 214:328-338(2012).
    Bhattacharya, P; Keating, AF; et al. Protective role for ovarian glutathione S-transferase isoform pi during 7,12-dimethylbenz[a]anthracene-induced ovotoxicity. TOXICOLOGY AND APPLIED PHARMACOLOGY 260:201-208(2012).

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