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Official Full Name mutL homolog 1
Background This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]
Synonyms MLH1; mutL homolog 1; FCC2; COCA2; HNPCC; hMLH1; HNPCC2; DNA mismatch repair protein Mlh1; mutL homolog 1, colon cancer, nonpolyposis type 2;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MLH1-1306H Recombinant Human MLH1 E.coli N/A
    Human MLH1-2320H Recombinant Human MLH1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MLH1-233H Recombinant Human MLH1, StrepII-tagged Human Cell Strep II
    Human MLH1-234H Recombinant Human MLH1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MLH1-4295HCL Recombinant Human MLH1 293 Cell Lysate HEK293 N/A
    Human MLH1-5385H Recombinant Human MLH1 Protein, GST-tagged Wheat Germ GST
    Mouse Mlh1-4089M Recombinant Mouse Mlh1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MLH1-9877M Recombinant Mouse MLH1 Protein Mammalian Cell His
    Rat MLH1-3701R Recombinant Rat MLH1 Protein Mammalian Cell His
    Zebrafish MLH1-10928Z Recombinant Zebrafish MLH1 Mammalian Cell His

    MLH1 involved in several pathways and played different roles in them. We selected most pathways MLH1 participated on our site, such as Mismatch repair, Fanconi anemia pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mismatch repair POLD1; POLD2; RPA3; RPA1; MSH3; POLD4; RPA4; MLH1; MLH3; MSH6
    Fanconi anemia pathway STRA13; RPA1; RPA4; CDK5R2; POLI; FANCL; POLH; BRCA1; FANCG; POLK
    Pathways in cancer CASP8; CUL2; RASSF1; FGF5; FGF21; LAMA5; FGF7; CSF1R; MAPK10; FOS
    Colorectal cancer BAD; TRP53; MSH2; MAPK1; AXIN2; MAPK8; BIRC5; MAPK10; SMAD2; PIK3R5
    Endometrial cancer MLH1; ELK1; KRAS; PIK3CD; TCF7L2; PIK3R5; CDH1; MAPK3; SOS1; ILK

    MLH1 has several biochemical functions, for example, ATP binding, ATPase activity, contributes_to MutSalpha complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLH1 itself. We selected most functions MLH1 had, and list some proteins which have the same functions with MLH1. You can find most of the proteins on our site.

    Function Related Protein
    ATPase activity MLH3; VWA8; HSPA5; KIF7; ABCD1; DNAH11; MACF1; WRN; MYH9; HSP90AA1
    contributes_to MutSalpha complex binding PMS2; MLH1
    mismatched DNA binding MSH6; MLH1; MLH3; MSH4; MSH5; TDG; PMS1
    protein binding NAT10; ADCK3; LRGUK; C21orf7; F8; AHCYL2; FAM65B; FMNL1; PPP4R2; FAM164A
    contributes_to protein binding INHA; CPSF3L; POLR2A; TGFBR3; PAK1; ACVR2A; MSH2; INTS10; MSH6; CRY1A
    contributes_to single-stranded DNA binding IGJ; MSH2; IGHM; PMS2; POLR2D; MLH1; MSH3

    MLH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLH1.

    PMS2; TMSB4X

    Roth, RM; Hampel, H; et al. A Modified Lynch Syndrome Screening Algorithm in Colon Cancer BRAF Immunohistochemistry Is Efficacious and Cost Beneficial. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:336-343(2015).
    Bettington, ML; Walker, NI; et al. A clinicopathological and molecular analysis of 200 traditional serrated adenomas. MODERN PATHOLOGY 28:414-427(2015).

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