|Official Full Name||mutL homolog 1|
|Background||This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]|
|Synonyms||MLH1; mutL homolog 1; FCC2; COCA2; HNPCC; hMLH1; HNPCC2; DNA mismatch repair protein Mlh1; mutL homolog 1, colon cancer, nonpolyposis type 2;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MLH1 involved in several pathways and played different roles in them. We selected most pathways MLH1 participated on our site, such as Mismatch repair, Fanconi anemia pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Mismatch repair||POLD1; POLD2; RPA3; RPA1; MSH3; POLD4; RPA4; MLH1; MLH3; MSH6|
|Fanconi anemia pathway||STRA13; RPA1; RPA4; CDK5R2; POLI; FANCL; POLH; BRCA1; FANCG; POLK|
|Pathways in cancer||CASP8; CUL2; RASSF1; FGF5; FGF21; LAMA5; FGF7; CSF1R; MAPK10; FOS|
|Colorectal cancer||BAD; TRP53; MSH2; MAPK1; AXIN2; MAPK8; BIRC5; MAPK10; SMAD2; PIK3R5|
|Endometrial cancer||MLH1; ELK1; KRAS; PIK3CD; TCF7L2; PIK3R5; CDH1; MAPK3; SOS1; ILK|
MLH1 has several biochemical functions, for example, ATP binding, ATPase activity, contributes_to MutSalpha complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLH1 itself. We selected most functions MLH1 had, and list some proteins which have the same functions with MLH1. You can find most of the proteins on our site.
|ATP binding||KIF3A; ABCC5; MYH11A; ADCY6; NADK; KIF5C; FKBP4; GK5; SHPRH; THRAP3|
|ATPase activity||MLH3; VWA8; HSPA5; KIF7; ABCD1; DNAH11; MACF1; WRN; MYH9; HSP90AA1|
|contributes_to MutSalpha complex binding||PMS2; MLH1|
|mismatched DNA binding||MSH6; MLH1; MLH3; MSH4; MSH5; TDG; PMS1|
|protein binding||NAT10; ADCK3; LRGUK; C21orf7; F8; AHCYL2; FAM65B; FMNL1; PPP4R2; FAM164A|
|contributes_to protein binding||INHA; CPSF3L; POLR2A; TGFBR3; PAK1; ACVR2A; MSH2; INTS10; MSH6; CRY1A|
|contributes_to single-stranded DNA binding||IGJ; MSH2; IGHM; PMS2; POLR2D; MLH1; MSH3|
MLH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLH1.